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Manganese in PDB 5kg0: Human Dna Polymerase Eta-Dna Ternary Complex: Reaction First with 1 Mm MN2+ For 1800S Then with 5 Mm MN2+ For 60S at 22 Degree
Enzymatic activity of Human Dna Polymerase Eta-Dna Ternary Complex: Reaction First with 1 Mm MN2+ For 1800S Then with 5 Mm MN2+ For 60S at 22 Degree
All present enzymatic activity of Human Dna Polymerase Eta-Dna Ternary Complex: Reaction First with 1 Mm MN2+ For 1800S Then with 5 Mm MN2+ For 60S at 22 Degree:
2.7.7.7;
2.7.7.7;
Protein crystallography data
The structure of Human Dna Polymerase Eta-Dna Ternary Complex: Reaction First with 1 Mm MN2+ For 1800S Then with 5 Mm MN2+ For 60S at 22 Degree, PDB code: 5kg0
was solved by
Y.Gao,
W.Yang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 19.91 / 1.60 |
| Space group | P 61 |
| Cell size a, b, c (Å), α, β, γ (°) | 98.080, 98.080, 81.900, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 17.6 / 21.1 |
Manganese Binding Sites:
The binding sites of Manganese atom in the Human Dna Polymerase Eta-Dna Ternary Complex: Reaction First with 1 Mm MN2+ For 1800S Then with 5 Mm MN2+ For 60S at 22 Degree
(pdb code 5kg0). This binding sites where shown within
5.0 Angstroms radius around Manganese atom.
In total 3 binding sites of Manganese where determined in the Human Dna Polymerase Eta-Dna Ternary Complex: Reaction First with 1 Mm MN2+ For 1800S Then with 5 Mm MN2+ For 60S at 22 Degree, PDB code: 5kg0:
Jump to Manganese binding site number: 1; 2; 3;
In total 3 binding sites of Manganese where determined in the Human Dna Polymerase Eta-Dna Ternary Complex: Reaction First with 1 Mm MN2+ For 1800S Then with 5 Mm MN2+ For 60S at 22 Degree, PDB code: 5kg0:
Jump to Manganese binding site number: 1; 2; 3;
Manganese binding site 1 out of 3 in 5kg0
Go back to
Manganese Binding Sites List in 5kg0
Manganese binding site 1 out
of 3 in the Human Dna Polymerase Eta-Dna Ternary Complex: Reaction First with 1 Mm MN2+ For 1800S Then with 5 Mm MN2+ For 60S at 22 Degree
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 1 of Human Dna Polymerase Eta-Dna Ternary Complex: Reaction First with 1 Mm MN2+ For 1800S Then with 5 Mm MN2+ For 60S at 22 Degree within 5.0Å range:
|
Manganese binding site 2 out of 3 in 5kg0
Go back to
Manganese Binding Sites List in 5kg0
Manganese binding site 2 out
of 3 in the Human Dna Polymerase Eta-Dna Ternary Complex: Reaction First with 1 Mm MN2+ For 1800S Then with 5 Mm MN2+ For 60S at 22 Degree
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 2 of Human Dna Polymerase Eta-Dna Ternary Complex: Reaction First with 1 Mm MN2+ For 1800S Then with 5 Mm MN2+ For 60S at 22 Degree within 5.0Å range:
|
Manganese binding site 3 out of 3 in 5kg0
Go back to
Manganese Binding Sites List in 5kg0
Manganese binding site 3 out
of 3 in the Human Dna Polymerase Eta-Dna Ternary Complex: Reaction First with 1 Mm MN2+ For 1800S Then with 5 Mm MN2+ For 60S at 22 Degree
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 3 of Human Dna Polymerase Eta-Dna Ternary Complex: Reaction First with 1 Mm MN2+ For 1800S Then with 5 Mm MN2+ For 60S at 22 Degree within 5.0Å range:
|
Reference:
Y.Gao,
W.Yang.
Capture of A Third MG2+ Is Essential For Catalyzing Dna Synthesis. Science V. 352 1334 2016.
ISSN: ESSN 1095-9203
PubMed: 27284197
DOI: 10.1126/SCIENCE.AAD9633
Page generated: Sun Oct 6 01:42:14 2024
ISSN: ESSN 1095-9203
PubMed: 27284197
DOI: 10.1126/SCIENCE.AAD9633
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