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Manganese in PDB 5jz8: Aspartyl/Asparaginyl Beta-Hydroxylase (Asph)Oxygenase and Tpr Domains in Complex with Manganese, N-Oxalylglycine, and Factor X Substrate Peptide Fragment (39MER)

Enzymatic activity of Aspartyl/Asparaginyl Beta-Hydroxylase (Asph)Oxygenase and Tpr Domains in Complex with Manganese, N-Oxalylglycine, and Factor X Substrate Peptide Fragment (39MER)

All present enzymatic activity of Aspartyl/Asparaginyl Beta-Hydroxylase (Asph)Oxygenase and Tpr Domains in Complex with Manganese, N-Oxalylglycine, and Factor X Substrate Peptide Fragment (39MER):
1.14.11.16; 3.4.21.6;

Protein crystallography data

The structure of Aspartyl/Asparaginyl Beta-Hydroxylase (Asph)Oxygenase and Tpr Domains in Complex with Manganese, N-Oxalylglycine, and Factor X Substrate Peptide Fragment (39MER), PDB code: 5jz8 was solved by M.A.Mcdonough, I.Pfeffer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.56 / 2.10
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 50.244, 91.020, 122.666, 90.00, 90.00, 90.00
R / Rfree (%) 18.8 / 21.6

Manganese Binding Sites:

The binding sites of Manganese atom in the Aspartyl/Asparaginyl Beta-Hydroxylase (Asph)Oxygenase and Tpr Domains in Complex with Manganese, N-Oxalylglycine, and Factor X Substrate Peptide Fragment (39MER) (pdb code 5jz8). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Aspartyl/Asparaginyl Beta-Hydroxylase (Asph)Oxygenase and Tpr Domains in Complex with Manganese, N-Oxalylglycine, and Factor X Substrate Peptide Fragment (39MER), PDB code: 5jz8:

Manganese binding site 1 out of 1 in 5jz8

Go back to Manganese Binding Sites List in 5jz8
Manganese binding site 1 out of 1 in the Aspartyl/Asparaginyl Beta-Hydroxylase (Asph)Oxygenase and Tpr Domains in Complex with Manganese, N-Oxalylglycine, and Factor X Substrate Peptide Fragment (39MER)


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Aspartyl/Asparaginyl Beta-Hydroxylase (Asph)Oxygenase and Tpr Domains in Complex with Manganese, N-Oxalylglycine, and Factor X Substrate Peptide Fragment (39MER) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn801

b:28.0
occ:1.00
 O2 A:OGA802 2.1 29.8 1.0
O B:HOH203 2.1 24.4 1.0
NE2 A:HIS725 2.2 26.5 1.0
NE2 A:HIS679 2.3 27.6 1.0
O2' A:OGA802 2.6 28.0 1.0
OD2 B:ASP103 2.6 31.6 0.6
C1 A:OGA802 2.9 29.8 1.0
C2 A:OGA802 3.0 31.7 1.0
CE1 A:HIS679 3.1 29.9 1.0
CD2 A:HIS725 3.1 26.0 1.0
CD2 A:HIS679 3.3 27.9 1.0
CE1 A:HIS725 3.3 28.6 1.0
CG B:ASP103 3.5 32.2 0.6
O1 A:OGA802 4.1 32.1 1.0
O B:ASP103 4.1 32.4 0.4
CB B:ASP103 4.2 31.8 0.6
O B:ASP103 4.2 32.5 0.6
CB B:ASP103 4.2 31.9 0.4
ND1 A:HIS679 4.3 29.1 1.0
NH1 A:ARG688 4.3 25.6 1.0
OD1 B:ASP103 4.3 33.5 0.6
CG A:HIS725 4.3 28.2 1.0
CG A:HIS679 4.3 28.3 1.0
ND1 A:HIS725 4.4 28.9 1.0
OD2 A:ASP721 4.4 29.1 1.0
N1 A:OGA802 4.4 34.9 1.0
CG B:ASP103 4.8 33.1 0.4
CA B:ASP103 4.8 33.1 0.4
CA B:ASP103 4.8 33.5 0.6
CB A:ASP721 4.8 29.1 1.0
C B:ASP103 4.9 32.4 0.4
OD1 B:ASP103 4.9 34.0 0.4
C B:ASP103 4.9 32.4 0.6

Reference:

I.Pfeffer, L.Brewitz, T.Krojer, S.A.Jensen, G.T.Kochan, N.J.Kershaw, K.S.Hewitson, L.A.Mcneill, H.Kramer, M.Munzel, R.J.Hopkinson, U.Oppermann, P.A.Handford, M.A.Mcdonough, C.J.Schofield. Aspartate/Asparagine-Beta-Hydroxylase Crystal Structures Reveal An Unexpected Epidermal Growth Factor-Like Domain Substrate Disulfide Pattern. Nat Commun V. 10 4910 2019.
ISSN: ESSN 2041-1723
PubMed: 31659163
DOI: 10.1038/S41467-019-12711-7
Page generated: Sun Oct 6 01:35:04 2024

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