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Manganese in PDB 5jqy: Aspartyl/Asparaginyl Beta-Hydroxylase (Asph)Oxygenase and Tpr Domains in Complex with Manganese, N-Oxalylglycine and Factor X Substrate Peptide Fragment(39MER-4SER)

Enzymatic activity of Aspartyl/Asparaginyl Beta-Hydroxylase (Asph)Oxygenase and Tpr Domains in Complex with Manganese, N-Oxalylglycine and Factor X Substrate Peptide Fragment(39MER-4SER)

All present enzymatic activity of Aspartyl/Asparaginyl Beta-Hydroxylase (Asph)Oxygenase and Tpr Domains in Complex with Manganese, N-Oxalylglycine and Factor X Substrate Peptide Fragment(39MER-4SER):
1.14.11.16; 3.4.21.6;

Protein crystallography data

The structure of Aspartyl/Asparaginyl Beta-Hydroxylase (Asph)Oxygenase and Tpr Domains in Complex with Manganese, N-Oxalylglycine and Factor X Substrate Peptide Fragment(39MER-4SER), PDB code: 5jqy was solved by M.A.Mcdonough, I.Pfeffer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.48 / 1.99
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 50.170, 89.540, 123.550, 90.00, 90.00, 90.00
R / Rfree (%) 19.1 / 20.5

Manganese Binding Sites:

The binding sites of Manganese atom in the Aspartyl/Asparaginyl Beta-Hydroxylase (Asph)Oxygenase and Tpr Domains in Complex with Manganese, N-Oxalylglycine and Factor X Substrate Peptide Fragment(39MER-4SER) (pdb code 5jqy). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Aspartyl/Asparaginyl Beta-Hydroxylase (Asph)Oxygenase and Tpr Domains in Complex with Manganese, N-Oxalylglycine and Factor X Substrate Peptide Fragment(39MER-4SER), PDB code: 5jqy:

Manganese binding site 1 out of 1 in 5jqy

Go back to Manganese Binding Sites List in 5jqy
Manganese binding site 1 out of 1 in the Aspartyl/Asparaginyl Beta-Hydroxylase (Asph)Oxygenase and Tpr Domains in Complex with Manganese, N-Oxalylglycine and Factor X Substrate Peptide Fragment(39MER-4SER)


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Aspartyl/Asparaginyl Beta-Hydroxylase (Asph)Oxygenase and Tpr Domains in Complex with Manganese, N-Oxalylglycine and Factor X Substrate Peptide Fragment(39MER-4SER) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn801

b:48.5
occ:1.00
 O A:HOH983 2.0 66.3 1.0
O2 A:OGA802 2.1 61.4 1.0
NE2 A:HIS725 2.2 25.1 1.0
NE2 A:HIS679 2.3 28.9 1.0
O2' A:OGA802 2.3 31.6 1.0
C1 A:OGA802 2.8 52.4 1.0
C2 A:OGA802 2.8 42.7 1.0
OD2 B:ASP103 2.9 33.2 0.6
CE1 A:HIS679 3.1 28.8 1.0
CD2 A:HIS725 3.1 24.7 1.0
CE1 A:HIS725 3.3 25.4 1.0
CD2 A:HIS679 3.3 29.3 1.0
CG B:ASP103 3.8 35.8 0.6
O1 A:OGA802 4.0 54.8 1.0
N1 A:OGA802 4.2 49.0 1.0
O B:ASP103 4.2 33.0 0.4
NH1 A:ARG688 4.2 28.1 1.0
ND1 A:HIS679 4.2 30.7 1.0
CG A:HIS725 4.3 26.3 1.0
O B:ASP103 4.3 32.5 0.6
ND1 A:HIS725 4.4 26.6 1.0
CG A:HIS679 4.4 31.4 1.0
CB B:ASP103 4.4 33.8 0.6
OD2 A:ASP721 4.4 28.5 1.0
CB B:ASP103 4.4 33.8 0.4
OD1 B:ASP103 4.6 35.9 0.6
O A:HOH962 4.7 31.6 1.0
CB A:ASP721 4.9 25.6 1.0
CH2 A:TRP625 5.0 24.9 1.0
CA B:ASP103 5.0 34.9 0.6

Reference:

I.Pfeffer, L.Brewitz, T.Krojer, S.A.Jensen, G.T.Kochan, N.J.Kershaw, K.S.Hewitson, L.A.Mcneill, H.Kramer, M.Munzel, R.J.Hopkinson, U.Oppermann, P.A.Handford, M.A.Mcdonough, C.J.Schofield. Aspartate/Asparagine-Beta-Hydroxylase Crystal Structures Reveal An Unexpected Epidermal Growth Factor-Like Domain Substrate Disulfide Pattern. Nat Commun V. 10 4910 2019.
ISSN: ESSN 2041-1723
PubMed: 31659163
DOI: 10.1038/S41467-019-12711-7
Page generated: Sun Oct 6 01:34:38 2024

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