Manganese in PDB 5jpf: Serine/Threonine Phosphatase Z1 (Candida Albicans) Binds to Inhibitor Microcystin-Lr

All present enzymatic activity of Serine/Threonine Phosphatase Z1 (Candida Albicans) Binds to Inhibitor Microcystin-Lr:
3.1.3.16;

The structure of Serine/Threonine Phosphatase Z1 (Candida Albicans) Binds to Inhibitor Microcystin-Lr, PDB code: 5jpf was solved by M.S.Choy, E.H.Chen, W.Peti, R.Page, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.88 / 2.40
Space group	P 32 2 1
Cell size a, b, c (Å), α, β, γ (°)	50.665, 50.665, 201.054, 90.00, 90.00, 120.00
R / Rfree (%)	17.9 / 23.4

The binding sites of Manganese atom in the Serine/Threonine Phosphatase Z1 (Candida Albicans) Binds to Inhibitor Microcystin-Lr (pdb code 5jpf). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the Serine/Threonine Phosphatase Z1 (Candida Albicans) Binds to Inhibitor Microcystin-Lr, PDB code: 5jpf:
Jump to Manganese binding site number: 1; 2;

Manganese binding site 1 out of 2 in the Serine/Threonine Phosphatase Z1 (Candida Albicans) Binds to Inhibitor Microcystin-Lr


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Serine/Threonine Phosphatase Z1 (Candida Albicans) Binds to Inhibitor Microcystin-Lr within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn501 b:20.9 occ:0.93 OD1 A:ASN289 2.1 22.8 1.0 O A:HOH618 2.2 25.4 1.0 OD2 A:ASP257 2.2 22.6 1.0 NE2 A:HIS338 2.2 22.9 1.0 ND1 A:HIS413 2.2 24.9 1.0 CE1 A:HIS413 3.0 25.0 1.0 CG A:ASP257 3.1 21.1 1.0 CE1 A:HIS338 3.1 21.4 1.0 MN A:MN502 3.1 22.2 0.9 CG A:ASN289 3.2 24.0 1.0 CD2 A:HIS338 3.3 22.9 1.0 CG A:HIS413 3.4 22.5 1.0 O M:HOH103 3.4 26.6 1.0 OD1 A:ASP257 3.4 17.9 1.0 CA A:HIS413 3.6 24.8 1.0 ND2 A:ASN289 3.7 20.5 1.0 CB A:HIS413 3.9 18.3 1.0 CD2 A:HIS290 3.9 22.0 1.0 OD2 A:ASP229 3.9 24.7 1.0 O A:HIS413 4.0 24.4 1.0 NE2 A:HIS413 4.2 22.2 1.0 ND1 A:HIS338 4.3 21.3 1.0 C A:HIS413 4.3 23.5 1.0 CG A:HIS338 4.4 22.8 1.0 CD2 A:HIS413 4.4 21.1 1.0 NE2 A:HIS290 4.4 23.9 1.0 CB A:ASP257 4.4 23.7 1.0 N A:ASN289 4.5 25.8 1.0 CB A:ASN289 4.5 20.2 1.0 O A:LEU370 4.6 22.1 1.0 N A:HIS413 4.6 19.7 1.0 NH2 A:ARG386 4.8 30.8 1.0 CG A:ASP229 4.8 23.6 1.0 O M:HOH104 4.9 23.4 1.0 OD1 A:ASP229 5.0 20.6 1.0 CA A:ASN289 5.0 21.7 1.0

Manganese binding site 2 out of 2 in the Serine/Threonine Phosphatase Z1 (Candida Albicans) Binds to Inhibitor Microcystin-Lr


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Serine/Threonine Phosphatase Z1 (Candida Albicans) Binds to Inhibitor Microcystin-Lr within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn502 b:22.2 occ:0.93 O A:HOH618 2.1 25.4 1.0 OD2 A:ASP229 2.1 24.7 1.0 OD2 A:ASP257 2.2 22.6 1.0 O M:HOH104 2.3 23.4 1.0 NE2 A:HIS231 2.3 21.1 1.0 MN A:MN501 3.1 20.9 0.9 CG A:ASP257 3.2 21.1 1.0 CE1 A:HIS231 3.2 20.8 1.0 CD2 A:HIS231 3.2 27.5 1.0 CG A:ASP229 3.2 23.6 1.0 CB A:ASP257 3.7 23.7 1.0 O A:HIS413 3.9 24.4 1.0 CB A:ASP229 4.0 21.3 1.0 NE2 A:HIS290 4.0 23.9 1.0 CD2 A:HIS290 4.0 22.0 1.0 O M:HOH103 4.1 26.6 1.0 OD1 A:ASP229 4.2 20.6 1.0 OD1 A:ASP257 4.3 17.9 1.0 ND1 A:HIS231 4.3 25.3 1.0 CG A:HIS231 4.4 27.9 1.0 CE1 A:PHE432 4.4 25.4 1.0 OH A:TYR437 4.5 30.8 1.0 CA A:HIS413 4.5 24.8 1.0 O M:FGA6 4.5 29.3 1.0 NE2 A:HIS338 4.5 22.9 1.0 C A:HIS413 4.5 23.5 1.0 CE1 A:HIS338 4.5 21.4 1.0 OXT M:FGA6 4.7 33.6 1.0 ND1 A:HIS413 4.7 24.9 1.0 OD1 A:ASN289 4.8 22.8 1.0 C M:FGA6 4.9 33.5 1.0 CE1 A:HIS290 5.0 23.0 1.0

E.Chen, M.S.Choy, K.Petrenyi, Z.Konya, F.Erdodi, V.Dombradi, W.Peti, R.Page. Molecular Insights Into the Fungus-Specific Serine/Threonine Protein Phosphatase Z1 in Candida Albicans. Mbio V. 7 2016.
ISSN: ESSN 2150-7511
PubMed: 27578752
DOI: 10.1128/MBIO.00872-16