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Atomistry » Manganese » PDB 5hzz-5jpf » 5iw0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Manganese » PDB 5hzz-5jpf » 5iw0 » |
Manganese in PDB 5iw0: Linked KDM5A Jmj Domain Bound to the Inhibitor N19 [2-(5-((4-Chloro-2- Methylbenzyl)Oxy)-1H-Pyrazol-1-Yl)Isonicotinic Acid]Protein crystallography data
The structure of Linked KDM5A Jmj Domain Bound to the Inhibitor N19 [2-(5-((4-Chloro-2- Methylbenzyl)Oxy)-1H-Pyrazol-1-Yl)Isonicotinic Acid], PDB code: 5iw0
was solved by
J.R.Horton,
X.Cheng,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5iw0:
The structure of Linked KDM5A Jmj Domain Bound to the Inhibitor N19 [2-(5-((4-Chloro-2- Methylbenzyl)Oxy)-1H-Pyrazol-1-Yl)Isonicotinic Acid] also contains other interesting chemical elements:
Manganese Binding Sites:
The binding sites of Manganese atom in the Linked KDM5A Jmj Domain Bound to the Inhibitor N19 [2-(5-((4-Chloro-2- Methylbenzyl)Oxy)-1H-Pyrazol-1-Yl)Isonicotinic Acid]
(pdb code 5iw0). This binding sites where shown within
5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Linked KDM5A Jmj Domain Bound to the Inhibitor N19 [2-(5-((4-Chloro-2- Methylbenzyl)Oxy)-1H-Pyrazol-1-Yl)Isonicotinic Acid], PDB code: 5iw0: Manganese binding site 1 out of 1 in 5iw0Go back to Manganese Binding Sites List in 5iw0
Manganese binding site 1 out
of 1 in the Linked KDM5A Jmj Domain Bound to the Inhibitor N19 [2-(5-((4-Chloro-2- Methylbenzyl)Oxy)-1H-Pyrazol-1-Yl)Isonicotinic Acid]
Mono view Stereo pair view
Reference:
J.R.Horton,
X.Liu,
M.Gale,
L.Wu,
J.R.Shanks,
X.Zhang,
P.J.Webber,
J.S.Bell,
S.C.Kales,
B.T.Mott,
G.Rai,
D.J.Jansen,
M.J.Henderson,
D.J.Urban,
M.D.Hall,
A.Simeonov,
D.J.Maloney,
M.A.Johns,
H.Fu,
A.Jadhav,
P.M.Vertino,
Q.Yan,
X.Cheng.
Structural Basis For KDM5A Histone Lysine Demethylase Inhibition By Diverse Compounds. Cell Chem Biol V. 23 769 2016.
Page generated: Tue Dec 15 04:42:04 2020
ISSN: ESSN 2451-9456 PubMed: 27427228 DOI: 10.1016/J.CHEMBIOL.2016.06.006 |
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