Manganese in PDB 4zs2: Structural Complex of Fto/Fluorescein

The structure of Structural Complex of Fto/Fluorescein, PDB code: 4zs2 was solved by T.Wang, T.Hong, Y.Huang, C.G.Yang, X.Zhou, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	28.97 / 2.16
Space group	H 3
Cell size a, b, c (Å), α, β, γ (°)	142.660, 142.660, 83.218, 90.00, 90.00, 120.00
R / Rfree (%)	19.8 / 22.9

The binding sites of Manganese atom in the Structural Complex of Fto/Fluorescein (pdb code 4zs2). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Structural Complex of Fto/Fluorescein, PDB code: 4zs2:

Manganese binding site 1 out of 1 in the Structural Complex of Fto/Fluorescein


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Structural Complex of Fto/Fluorescein within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn603 b:62.0 occ:1.00 O A:HOH753 2.4 48.8 1.0 O5 A:AKG601 2.5 56.5 1.0 NE2 A:HIS307 2.5 34.9 1.0 OD1 A:ASP233 2.6 39.8 1.0 C2 A:AKG601 2.7 57.3 1.0 O1 A:AKG601 2.8 70.7 1.0 NE2 A:HIS231 2.8 33.2 1.0 C1 A:AKG601 3.1 63.2 1.0 C3 A:AKG601 3.4 53.6 1.0 CG A:ASP233 3.4 36.6 1.0 OD2 A:ASP233 3.4 40.0 1.0 CE1 A:HIS307 3.4 37.2 1.0 CE1 A:HIS231 3.5 33.4 1.0 CD2 A:HIS307 3.5 35.0 1.0 C4 A:AKG601 3.6 49.5 1.0 O A:HOH730 3.7 50.4 1.0 CD2 A:HIS231 3.9 32.9 1.0 NH2 A:ARG322 4.3 48.7 1.0 O2 A:AKG601 4.4 65.1 1.0 ND1 A:HIS307 4.6 34.6 1.0 CG A:HIS307 4.6 34.8 1.0 ND1 A:HIS231 4.7 33.3 1.0 CB A:ASP233 4.8 37.6 1.0 CG A:HIS231 5.0 33.0 1.0

T.Wang, T.Hong, Y.Huang, H.Su, F.Wu, Y.Chen, L.Wei, W.Huang, X.Hua, Y.Xia, J.Xu, J.Gan, B.Yuan, Y.Feng, X.Zhang, C.G.Yang, X.Zhou. Fluorescein Derivatives As Bifunctional Molecules For the Simultaneous Inhibiting and Labeling of Fto Protein J.Am.Chem.Soc. V. 137 13736 2015.
ISSN: ESSN 1520-5126
PubMed: 26457839
DOI: 10.1021/JACS.5B06690