Manganese in PDB 4zhz: Endonuclease Inhibitor Bound to Influenza Strain H1N1 Polymerase Acidic Subunit N-Terminal Region with Expelling One of the Metal Ions in the Active Site

The structure of Endonuclease Inhibitor Bound to Influenza Strain H1N1 Polymerase Acidic Subunit N-Terminal Region with Expelling One of the Metal Ions in the Active Site, PDB code: 4zhz was solved by S.Fudo, N.Yamamoto, M.Nukaga, T.Odagiri, M.Tashiro, S.Neya, T.Hoshino, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	38.04 / 2.50
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	66.562, 66.562, 129.173, 90.00, 90.00, 90.00
R / Rfree (%)	22.2 / 27

The structure of Endonuclease Inhibitor Bound to Influenza Strain H1N1 Polymerase Acidic Subunit N-Terminal Region with Expelling One of the Metal Ions in the Active Site also contains other interesting chemical elements:

Chlorine

(Cl)

2 atoms

The binding sites of Manganese atom in the Endonuclease Inhibitor Bound to Influenza Strain H1N1 Polymerase Acidic Subunit N-Terminal Region with Expelling One of the Metal Ions in the Active Site (pdb code 4zhz). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Endonuclease Inhibitor Bound to Influenza Strain H1N1 Polymerase Acidic Subunit N-Terminal Region with Expelling One of the Metal Ions in the Active Site, PDB code: 4zhz:

Manganese binding site 1 out of 1 in the Endonuclease Inhibitor Bound to Influenza Strain H1N1 Polymerase Acidic Subunit N-Terminal Region with Expelling One of the Metal Ions in the Active Site


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Endonuclease Inhibitor Bound to Influenza Strain H1N1 Polymerase Acidic Subunit N-Terminal Region with Expelling One of the Metal Ions in the Active Site within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn303 b:86.0 occ:1.00 OD1 A:ASP108 2.6 28.0 1.0 CAC A:4P8301 2.8 57.6 1.0 OE1 A:GLU80 2.9 61.3 1.0 O A:LEU106 3.2 41.6 1.0 OE2 A:GLU119 3.3 40.7 1.0 CAD A:4P8301 3.5 60.7 1.0 CG A:ASP108 3.5 28.9 1.0 CD A:GLU80 3.8 55.9 1.0 OD2 A:ASP108 3.9 31.2 1.0 CAB A:4P8301 3.9 71.4 1.0 CAJ A:4P8301 4.0 38.7 1.0 NE2 A:HIS41 4.0 25.4 1.0 OE1 A:GLU119 4.0 44.8 1.0 CD A:GLU119 4.1 39.2 1.0 CAH A:4P8301 4.2 52.4 1.0 OAT A:4P8301 4.2 63.4 1.0 O A:PRO107 4.2 24.3 1.0 C A:PRO107 4.2 32.5 1.0 C A:LEU106 4.3 44.2 1.0 O A:HOH414 4.3 45.0 1.0 OE2 A:GLU80 4.4 41.9 1.0 N A:ASP108 4.5 26.9 1.0 CAI A:4P8301 4.6 44.1 1.0 CA A:ASP108 4.6 35.5 1.0 CE1 A:HIS41 4.6 23.6 1.0 CB A:ASP108 4.7 24.8 1.0 CG A:GLU80 4.7 43.8 1.0 CA A:PRO107 4.7 31.7 1.0 CAE A:4P8301 4.9 67.0 1.0 CLG A:4P8302 4.9 89.1 1.0 CD2 A:HIS41 5.0 17.8 1.0

S.Fudo, N.Yamamoto, M.Nukaga, T.Odagiri, M.Tashiro, S.Neya, T.Hoshino. Analysis of the Distinctive Binding Modes of Two Endonuclease Inhibitors to Influenza Virus Polymerase Acidic Subunit N-Terminal Region To Be Published.