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Manganese in PDB 4y7f: Crystal Structure of Glucosyl-3-Phosphoglycerate Synthase From Mycobacterium Tuberculosis in Complex with MN2+, Uridine-Diphosphate- Glucose (Udp-Glc) and 3-(Phosphonooxy)Propanoic Acid (Ppa) - Gpgs MN2+ Udp-Glc Ppa

Enzymatic activity of Crystal Structure of Glucosyl-3-Phosphoglycerate Synthase From Mycobacterium Tuberculosis in Complex with MN2+, Uridine-Diphosphate- Glucose (Udp-Glc) and 3-(Phosphonooxy)Propanoic Acid (Ppa) - Gpgs MN2+ Udp-Glc Ppa

All present enzymatic activity of Crystal Structure of Glucosyl-3-Phosphoglycerate Synthase From Mycobacterium Tuberculosis in Complex with MN2+, Uridine-Diphosphate- Glucose (Udp-Glc) and 3-(Phosphonooxy)Propanoic Acid (Ppa) - Gpgs MN2+ Udp-Glc Ppa:
2.4.1.266;

Protein crystallography data

The structure of Crystal Structure of Glucosyl-3-Phosphoglycerate Synthase From Mycobacterium Tuberculosis in Complex with MN2+, Uridine-Diphosphate- Glucose (Udp-Glc) and 3-(Phosphonooxy)Propanoic Acid (Ppa) - Gpgs MN2+ Udp-Glc Ppa, PDB code: 4y7f was solved by D.Albesa-Jove, A.Rodrigo-Unzueta, J.O.Cifuente, S.Urresti, N.Comino, E.Sancho-Vaello, M.E.Guerin, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 69.25 / 3.23
Space group I 41
Cell size a, b, c (Å), α, β, γ (°) 97.940, 97.940, 126.780, 90.00, 90.00, 90.00
R / Rfree (%) 17 / 20.8

Manganese Binding Sites:

The binding sites of Manganese atom in the Crystal Structure of Glucosyl-3-Phosphoglycerate Synthase From Mycobacterium Tuberculosis in Complex with MN2+, Uridine-Diphosphate- Glucose (Udp-Glc) and 3-(Phosphonooxy)Propanoic Acid (Ppa) - Gpgs MN2+ Udp-Glc Ppa (pdb code 4y7f). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Crystal Structure of Glucosyl-3-Phosphoglycerate Synthase From Mycobacterium Tuberculosis in Complex with MN2+, Uridine-Diphosphate- Glucose (Udp-Glc) and 3-(Phosphonooxy)Propanoic Acid (Ppa) - Gpgs MN2+ Udp-Glc Ppa, PDB code: 4y7f:

Manganese binding site 1 out of 1 in 4y7f

Go back to Manganese Binding Sites List in 4y7f
Manganese binding site 1 out of 1 in the Crystal Structure of Glucosyl-3-Phosphoglycerate Synthase From Mycobacterium Tuberculosis in Complex with MN2+, Uridine-Diphosphate- Glucose (Udp-Glc) and 3-(Phosphonooxy)Propanoic Acid (Ppa) - Gpgs MN2+ Udp-Glc Ppa


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Crystal Structure of Glucosyl-3-Phosphoglycerate Synthase From Mycobacterium Tuberculosis in Complex with MN2+, Uridine-Diphosphate- Glucose (Udp-Glc) and 3-(Phosphonooxy)Propanoic Acid (Ppa) - Gpgs MN2+ Udp-Glc Ppa within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn401

b:57.7
occ:1.00
 ND1 A:HIS258 2.1 64.0 1.0
OD2 A:ASP136 2.1 50.6 1.0
O2B A:UPG403 2.2 59.4 1.0
O A:HOH509 2.2 40.3 1.0
O A:HOH506 2.2 61.9 1.0
O1A A:UPG403 2.3 58.6 1.0
CE1 A:HIS258 2.8 62.7 1.0
CG A:ASP136 3.0 48.8 1.0
CG A:HIS258 3.2 64.3 1.0
OD1 A:ASP136 3.2 47.2 1.0
PB A:UPG403 3.3 57.5 1.0
PA A:UPG403 3.6 52.9 1.0
CB A:HIS258 3.8 60.4 1.0
O3A A:UPG403 3.8 59.9 1.0
O1B A:UPG403 3.9 58.1 1.0
NE2 A:HIS258 3.9 65.4 1.0
O2' A:UPG403 3.9 57.3 1.0
NH2 A:ARG256 4.1 73.4 1.0
CD2 A:HIS258 4.1 67.0 1.0
O A:ARG259 4.4 46.6 1.0
C5C A:UPG403 4.4 51.3 1.0
CB A:ASP136 4.4 49.6 1.0
OD2 A:ASP134 4.5 57.0 1.0
O5C A:UPG403 4.6 50.5 1.0
N A:ARG259 4.6 39.9 1.0
O2A A:UPG403 4.6 49.9 1.0
NH2 A:ARG259 4.6 31.2 0.6
O3B A:UPG403 4.7 56.2 1.0
C2' A:UPG403 4.9 58.4 1.0
CB A:ARG259 4.9 38.9 0.6
CB A:ARG259 5.0 38.9 0.4

Reference:

D.Albesa-Jove, F.Mendoza, A.Rodrigo-Unzueta, F.Gomollon-Bel, J.O.Cifuente, S.Urresti, N.Comino, H.Gomez, J.Romero-Garcia, J.M.Lluch, E.Sancho-Vaello, X.Biarnes, A.Planas, P.Merino, L.Masgrau, M.E.Guerin. A Native Ternary Complex Trapped in A Crystal Reveals the Catalytic Mechanism of A Retaining Glycosyltransferase. Angew.Chem.Int.Ed.Engl. V. 54 9898 2015.
ISSN: ESSN 1521-3773
PubMed: 26136334
DOI: 10.1002/ANIE.201504617
Page generated: Sat Oct 5 23:01:24 2024

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