Manganese »
PDB 4wl8-4xwt »
4wtg »
Manganese in PDB 4wtg: Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Sofosbuvir Diphosphate Gs-607596, MN2+ and Symmetrical Primer Template 5'-Caaaauuu
Enzymatic activity of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Sofosbuvir Diphosphate Gs-607596, MN2+ and Symmetrical Primer Template 5'-Caaaauuu
All present enzymatic activity of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Sofosbuvir Diphosphate Gs-607596, MN2+ and Symmetrical Primer Template 5'-Caaaauuu:
2.7.7.48;
2.7.7.48;
Protein crystallography data
The structure of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Sofosbuvir Diphosphate Gs-607596, MN2+ and Symmetrical Primer Template 5'-Caaaauuu, PDB code: 4wtg
was solved by
T.E.Edwards,
T.C.Appleby,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 50.00 / 2.90 |
| Space group | P 65 |
| Cell size a, b, c (Å), α, β, γ (°) | 140.440, 140.440, 91.620, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 17.9 / 23.2 |
Other elements in 4wtg:
The structure of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Sofosbuvir Diphosphate Gs-607596, MN2+ and Symmetrical Primer Template 5'-Caaaauuu also contains other interesting chemical elements:
| Fluorine | (F) | 1 atom |
| Chlorine | (Cl) | 1 atom |
Manganese Binding Sites:
The binding sites of Manganese atom in the Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Sofosbuvir Diphosphate Gs-607596, MN2+ and Symmetrical Primer Template 5'-Caaaauuu
(pdb code 4wtg). This binding sites where shown within
5.0 Angstroms radius around Manganese atom.
In total 3 binding sites of Manganese where determined in the Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Sofosbuvir Diphosphate Gs-607596, MN2+ and Symmetrical Primer Template 5'-Caaaauuu, PDB code: 4wtg:
Jump to Manganese binding site number: 1; 2; 3;
In total 3 binding sites of Manganese where determined in the Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Sofosbuvir Diphosphate Gs-607596, MN2+ and Symmetrical Primer Template 5'-Caaaauuu, PDB code: 4wtg:
Jump to Manganese binding site number: 1; 2; 3;
Manganese binding site 1 out of 3 in 4wtg
Go back to
Manganese Binding Sites List in 4wtg
Manganese binding site 1 out
of 3 in the Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Sofosbuvir Diphosphate Gs-607596, MN2+ and Symmetrical Primer Template 5'-Caaaauuu
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 1 of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Sofosbuvir Diphosphate Gs-607596, MN2+ and Symmetrical Primer Template 5'-Caaaauuu within 5.0Å range:
|
Manganese binding site 2 out of 3 in 4wtg
Go back to
Manganese Binding Sites List in 4wtg
Manganese binding site 2 out
of 3 in the Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Sofosbuvir Diphosphate Gs-607596, MN2+ and Symmetrical Primer Template 5'-Caaaauuu
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 2 of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Sofosbuvir Diphosphate Gs-607596, MN2+ and Symmetrical Primer Template 5'-Caaaauuu within 5.0Å range:
|
Manganese binding site 3 out of 3 in 4wtg
Go back to
Manganese Binding Sites List in 4wtg
Manganese binding site 3 out
of 3 in the Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Sofosbuvir Diphosphate Gs-607596, MN2+ and Symmetrical Primer Template 5'-Caaaauuu
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 3 of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Sofosbuvir Diphosphate Gs-607596, MN2+ and Symmetrical Primer Template 5'-Caaaauuu within 5.0Å range:
|
Reference:
T.C.Appleby,
J.Perry,
E.Murakami,
O.Barauskas,
J.Feng,
A.Cho,
D.Fox Iii,
D.R.Wetmore,
M.E.Mcgrath,
A.S.Ray,
M.J.Sofia,
S.Swaminathan,
T.E.Edwards.
Structural Basis For Rna Replication By the Hepatitis C Virus Polymerase To Be Published.
Page generated: Sat Oct 5 22:52:11 2024
Last articles
Zn in 9JPJZn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
