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Manganese in PDB 4wtc: Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Cdp, MN2+ and Symmetrical Primer Template 5'-Agaaauuu
Enzymatic activity of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Cdp, MN2+ and Symmetrical Primer Template 5'-Agaaauuu
All present enzymatic activity of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Cdp, MN2+ and Symmetrical Primer Template 5'-Agaaauuu:
2.7.7.48;
2.7.7.48;
Protein crystallography data
The structure of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Cdp, MN2+ and Symmetrical Primer Template 5'-Agaaauuu, PDB code: 4wtc
was solved by
T.E.Edwards,
T.C.Appleby,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 50.00 / 2.75 |
| Space group | P 65 |
| Cell size a, b, c (Å), α, β, γ (°) | 141.340, 141.340, 90.800, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 17.8 / 22.9 |
Other elements in 4wtc:
The structure of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Cdp, MN2+ and Symmetrical Primer Template 5'-Agaaauuu also contains other interesting chemical elements:
| Chlorine | (Cl) | 1 atom |
Manganese Binding Sites:
The binding sites of Manganese atom in the Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Cdp, MN2+ and Symmetrical Primer Template 5'-Agaaauuu
(pdb code 4wtc). This binding sites where shown within
5.0 Angstroms radius around Manganese atom.
In total 3 binding sites of Manganese where determined in the Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Cdp, MN2+ and Symmetrical Primer Template 5'-Agaaauuu, PDB code: 4wtc:
Jump to Manganese binding site number: 1; 2; 3;
In total 3 binding sites of Manganese where determined in the Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Cdp, MN2+ and Symmetrical Primer Template 5'-Agaaauuu, PDB code: 4wtc:
Jump to Manganese binding site number: 1; 2; 3;
Manganese binding site 1 out of 3 in 4wtc
Go back to
Manganese Binding Sites List in 4wtc
Manganese binding site 1 out
of 3 in the Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Cdp, MN2+ and Symmetrical Primer Template 5'-Agaaauuu
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 1 of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Cdp, MN2+ and Symmetrical Primer Template 5'-Agaaauuu within 5.0Å range:
|
Manganese binding site 2 out of 3 in 4wtc
Go back to
Manganese Binding Sites List in 4wtc
Manganese binding site 2 out
of 3 in the Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Cdp, MN2+ and Symmetrical Primer Template 5'-Agaaauuu
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 2 of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Cdp, MN2+ and Symmetrical Primer Template 5'-Agaaauuu within 5.0Å range:
|
Manganese binding site 3 out of 3 in 4wtc
Go back to
Manganese Binding Sites List in 4wtc
Manganese binding site 3 out
of 3 in the Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Cdp, MN2+ and Symmetrical Primer Template 5'-Agaaauuu
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 3 of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Cdp, MN2+ and Symmetrical Primer Template 5'-Agaaauuu within 5.0Å range:
|
Reference:
T.C.Appleby,
J.Perry,
E.Murakami,
O.Barauskas,
J.Feng,
A.Cho,
D.Fox Iii,
D.R.Wetmore,
M.E.Mcgrath,
A.S.Ray,
M.J.Sofia,
S.Swaminathan,
T.E.Edwards.
Structural Basis For Rna Replication By the Hepatitis C Virus Polymerase To Be Published.
Page generated: Sat Oct 5 22:51:35 2024
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