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Manganese in PDB 4v0w: The Crystal Structure of Mouse PP1G in Complex with Truncated Human PPP1R15B (631-669)

Enzymatic activity of The Crystal Structure of Mouse PP1G in Complex with Truncated Human PPP1R15B (631-669)

All present enzymatic activity of The Crystal Structure of Mouse PP1G in Complex with Truncated Human PPP1R15B (631-669):
3.1.3.16;

Protein crystallography data

The structure of The Crystal Structure of Mouse PP1G in Complex with Truncated Human PPP1R15B (631-669), PDB code: 4v0w was solved by R.Chen, Y.Yan, A.C.Casado, D.Ron, R.J.Read, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 33.936 / 1.55
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 67.010, 67.860, 156.750, 90.00, 90.00, 90.00
R / Rfree (%) 17.27 / 20.29

Manganese Binding Sites:

The binding sites of Manganese atom in the The Crystal Structure of Mouse PP1G in Complex with Truncated Human PPP1R15B (631-669) (pdb code 4v0w). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 4 binding sites of Manganese where determined in the The Crystal Structure of Mouse PP1G in Complex with Truncated Human PPP1R15B (631-669), PDB code: 4v0w:
Jump to Manganese binding site number: 1; 2; 3; 4;

Manganese binding site 1 out of 4 in 4v0w

Go back to Manganese Binding Sites List in 4v0w
Manganese binding site 1 out of 4 in the The Crystal Structure of Mouse PP1G in Complex with Truncated Human PPP1R15B (631-669)


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of The Crystal Structure of Mouse PP1G in Complex with Truncated Human PPP1R15B (631-669) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn301

b:12.2
occ:0.25
 O A:HOH302 1.6 19.4 0.8
O A:HOH2115 2.0 41.9 1.0
OD2 A:ASP64 2.1 17.3 1.0
OD2 A:ASP92 2.1 13.6 1.0
NE2 A:HIS66 2.2 15.2 1.0
MN A:MN303 3.0 13.5 0.8
CE1 A:HIS66 3.0 20.5 1.0
CG A:ASP92 3.1 15.0 1.0
CG A:ASP64 3.2 15.8 1.0
O A:HOH2152 3.3 22.1 1.0
CD2 A:HIS66 3.3 16.8 1.0
CB A:ASP92 3.6 11.2 1.0
OD1 A:ASP64 4.1 16.6 1.0
CB A:ASP64 4.1 11.5 1.0
CD2 A:HIS125 4.1 12.7 1.0
OD1 A:ASP92 4.2 13.0 1.0
ND1 A:HIS66 4.2 15.8 1.0
O A:HOH2176 4.2 36.7 1.0
NE2 A:HIS125 4.3 15.7 1.0
NE2 A:HIS173 4.4 12.3 1.0
CG A:HIS66 4.4 13.7 1.0
CE2 A:PHE267 4.4 15.3 1.0
CE1 A:HIS173 4.4 13.3 1.0
OH A:TYR272 4.5 33.8 1.0
O A:HOH2312 4.5 42.8 1.0
O A:HIS248 4.5 21.0 1.0
CA A:HIS248 4.6 12.2 1.0
OD1 A:ASN124 4.7 13.9 1.0
ND1 A:HIS248 4.8 14.3 1.0
C A:HIS248 4.9 15.8 1.0

Manganese binding site 2 out of 4 in 4v0w

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Manganese binding site 2 out of 4 in the The Crystal Structure of Mouse PP1G in Complex with Truncated Human PPP1R15B (631-669)


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of The Crystal Structure of Mouse PP1G in Complex with Truncated Human PPP1R15B (631-669) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn303

b:13.5
occ:0.77
 OD1 A:ASN124 2.1 13.9 1.0
OD2 A:ASP92 2.2 13.6 1.0
O A:HOH302 2.2 19.4 0.8
NE2 A:HIS173 2.2 12.3 1.0
ND1 A:HIS248 2.3 14.3 1.0
O A:HOH2152 2.5 22.1 1.0
MN A:MN301 3.0 12.2 0.2
CE1 A:HIS248 3.1 21.2 1.0
CE1 A:HIS173 3.2 13.3 1.0
CG A:ASP92 3.2 15.0 1.0
CG A:ASN124 3.2 12.4 1.0
CD2 A:HIS173 3.2 8.8 1.0
CG A:HIS248 3.4 13.5 1.0
OD1 A:ASP92 3.5 13.0 1.0
ND2 A:ASN124 3.7 14.7 1.0
CA A:HIS248 3.8 12.2 1.0
CB A:HIS248 3.9 12.2 1.0
OD2 A:ASP64 4.0 17.3 1.0
O A:HOH2115 4.1 41.9 1.0
CD2 A:HIS125 4.2 12.7 1.0
O A:HIS248 4.2 21.0 1.0
NE2 A:HIS248 4.3 17.3 1.0
ND1 A:HIS173 4.3 10.2 1.0
CG A:HIS173 4.4 9.3 1.0
CB A:ASP92 4.4 11.2 1.0
CD2 A:HIS248 4.5 14.3 1.0
N A:ASN124 4.5 10.3 1.0
CB A:ASN124 4.5 11.1 1.0
C A:HIS248 4.5 15.8 1.0
O A:HOH2176 4.5 36.7 1.0
NE2 A:HIS125 4.8 15.7 1.0
N A:HIS248 4.8 12.7 1.0
O A:LEU205 4.8 12.1 1.0
CG A:ASP64 4.8 15.8 1.0
OD1 A:ASP64 4.9 16.6 1.0
NE2 A:HIS66 5.0 15.2 1.0
CA A:ASN124 5.0 10.4 1.0

Manganese binding site 3 out of 4 in 4v0w

Go back to Manganese Binding Sites List in 4v0w
Manganese binding site 3 out of 4 in the The Crystal Structure of Mouse PP1G in Complex with Truncated Human PPP1R15B (631-669)


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 3 of The Crystal Structure of Mouse PP1G in Complex with Truncated Human PPP1R15B (631-669) within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Mn301

b:10.4
occ:0.22
 O C:HOH302 1.9 16.0 0.8
O C:HOH2066 2.0 40.8 1.0
NE2 C:HIS66 2.1 19.1 1.0
OD2 C:ASP64 2.1 16.0 1.0
OD2 C:ASP92 2.2 14.5 1.0
CE1 C:HIS66 2.9 20.2 1.0
MN C:MN303 3.1 13.7 0.8
CD2 C:HIS66 3.2 16.7 1.0
CG C:ASP92 3.2 13.9 1.0
CG C:ASP64 3.3 14.6 1.0
O C:HOH2092 3.4 17.0 1.0
CB C:ASP92 3.7 10.8 1.0
O C:HOH2195 3.9 37.0 1.0
CB C:ASP64 4.1 12.9 1.0
CD2 C:HIS125 4.1 13.8 1.0
ND1 C:HIS66 4.1 19.8 1.0
OD1 C:ASP64 4.1 15.9 1.0
CG C:HIS66 4.3 14.1 1.0
OD1 C:ASP92 4.3 13.5 1.0
NE2 C:HIS125 4.3 17.3 1.0
OH C:TYR272 4.4 28.2 1.0
NE2 C:HIS173 4.5 12.9 1.0
CE1 C:PHE267 4.5 14.5 1.0
CE1 C:HIS173 4.5 17.6 1.0
O C:HIS248 4.6 23.9 1.0
CA C:HIS248 4.7 14.2 1.0
OD1 C:ASN124 4.8 15.3 1.0
ND1 C:HIS248 4.9 12.1 1.0
C C:HIS248 4.9 16.1 1.0

Manganese binding site 4 out of 4 in 4v0w

Go back to Manganese Binding Sites List in 4v0w
Manganese binding site 4 out of 4 in the The Crystal Structure of Mouse PP1G in Complex with Truncated Human PPP1R15B (631-669)


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 4 of The Crystal Structure of Mouse PP1G in Complex with Truncated Human PPP1R15B (631-669) within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Mn303

b:13.7
occ:0.85
 OD1 C:ASN124 2.2 15.3 1.0
OD2 C:ASP92 2.2 14.5 1.0
NE2 C:HIS173 2.2 12.9 1.0
O C:HOH302 2.2 16.0 0.8
ND1 C:HIS248 2.3 12.1 1.0
O C:HOH2092 2.4 17.0 1.0
CE1 C:HIS248 3.1 18.1 1.0
MN C:MN301 3.1 10.4 0.2
CE1 C:HIS173 3.2 17.6 1.0
CG C:ASP92 3.2 13.9 1.0
CD2 C:HIS173 3.2 12.4 1.0
CG C:ASN124 3.2 14.2 1.0
CG C:HIS248 3.4 11.2 1.0
OD1 C:ASP92 3.6 13.5 1.0
ND2 C:ASN124 3.7 15.0 1.0
CA C:HIS248 3.7 14.2 1.0
CB C:HIS248 3.9 12.1 1.0
OD2 C:ASP64 3.9 16.0 1.0
O C:HOH2195 4.0 37.0 1.0
CD2 C:HIS125 4.1 13.8 1.0
O C:HIS248 4.2 23.9 1.0
O C:HOH2066 4.2 40.8 1.0
ND1 C:HIS173 4.3 12.6 1.0
NE2 C:HIS248 4.3 14.9 1.0
CG C:HIS173 4.3 12.2 1.0
CB C:ASP92 4.4 10.8 1.0
C C:HIS248 4.5 16.1 1.0
CD2 C:HIS248 4.5 12.3 1.0
CB C:ASN124 4.5 12.0 1.0
N C:ASN124 4.5 12.6 1.0
NE2 C:HIS125 4.7 17.3 1.0
N C:HIS248 4.7 11.0 1.0
O C:LEU205 4.8 13.0 1.0
CG C:ASP64 4.8 14.6 1.0
OD1 C:ASP64 4.9 15.9 1.0
NE2 C:HIS66 5.0 19.1 1.0

Reference:

R.Chen, C.Rato, Y.Yan, A.Crespillo-Casado, H.J.Clarke, H.P.Harding, S.J.Marciniak, R.J.Read, D.Ron. G-Actin Provides Substrate-Specificity to Eukaryotic Initiation Factor 2ALPHA Holophosphatases. Elife V. 4 2015.
ISSN: ISSN 2050-084X
PubMed: 25774600
DOI: 10.7554/ELIFE.04871
Page generated: Sat Oct 5 21:29:33 2024

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