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Manganese in PDB 4uma: Structural Analysis of Substrate-Mimicking Inhibitors in Complex with Neisseria Meningitidis 3 Deoxy D Arabino Heptulosonate 7 Phosphate Synthase the Importance of Accommodating the Active Site Water
Enzymatic activity of Structural Analysis of Substrate-Mimicking Inhibitors in Complex with Neisseria Meningitidis 3 Deoxy D Arabino Heptulosonate 7 Phosphate Synthase the Importance of Accommodating the Active Site Water
All present enzymatic activity of Structural Analysis of Substrate-Mimicking Inhibitors in Complex with Neisseria Meningitidis 3 Deoxy D Arabino Heptulosonate 7 Phosphate Synthase the Importance of Accommodating the Active Site Water:
2.5.1.54;
2.5.1.54;
Protein crystallography data
The structure of Structural Analysis of Substrate-Mimicking Inhibitors in Complex with Neisseria Meningitidis 3 Deoxy D Arabino Heptulosonate 7 Phosphate Synthase the Importance of Accommodating the Active Site Water, PDB code: 4uma
was solved by
L.C.Heyes,
S.Reichau,
P.J.Cross,
E.J.Parker,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 73.04 / 1.76 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 73.495, 136.501, 76.157, 90.00, 96.41, 90.00 |
| R / Rfree (%) | 19.061 / 21.44 |
Manganese Binding Sites:
The binding sites of Manganese atom in the Structural Analysis of Substrate-Mimicking Inhibitors in Complex with Neisseria Meningitidis 3 Deoxy D Arabino Heptulosonate 7 Phosphate Synthase the Importance of Accommodating the Active Site Water
(pdb code 4uma). This binding sites where shown within
5.0 Angstroms radius around Manganese atom.
In total 4 binding sites of Manganese where determined in the Structural Analysis of Substrate-Mimicking Inhibitors in Complex with Neisseria Meningitidis 3 Deoxy D Arabino Heptulosonate 7 Phosphate Synthase the Importance of Accommodating the Active Site Water, PDB code: 4uma:
Jump to Manganese binding site number: 1; 2; 3; 4;
In total 4 binding sites of Manganese where determined in the Structural Analysis of Substrate-Mimicking Inhibitors in Complex with Neisseria Meningitidis 3 Deoxy D Arabino Heptulosonate 7 Phosphate Synthase the Importance of Accommodating the Active Site Water, PDB code: 4uma:
Jump to Manganese binding site number: 1; 2; 3; 4;
Manganese binding site 1 out of 4 in 4uma
Go back to
Manganese Binding Sites List in 4uma
Manganese binding site 1 out
of 4 in the Structural Analysis of Substrate-Mimicking Inhibitors in Complex with Neisseria Meningitidis 3 Deoxy D Arabino Heptulosonate 7 Phosphate Synthase the Importance of Accommodating the Active Site Water
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 1 of Structural Analysis of Substrate-Mimicking Inhibitors in Complex with Neisseria Meningitidis 3 Deoxy D Arabino Heptulosonate 7 Phosphate Synthase the Importance of Accommodating the Active Site Water within 5.0Å range:
|
Manganese binding site 2 out of 4 in 4uma
Go back to
Manganese Binding Sites List in 4uma
Manganese binding site 2 out
of 4 in the Structural Analysis of Substrate-Mimicking Inhibitors in Complex with Neisseria Meningitidis 3 Deoxy D Arabino Heptulosonate 7 Phosphate Synthase the Importance of Accommodating the Active Site Water
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 2 of Structural Analysis of Substrate-Mimicking Inhibitors in Complex with Neisseria Meningitidis 3 Deoxy D Arabino Heptulosonate 7 Phosphate Synthase the Importance of Accommodating the Active Site Water within 5.0Å range:
|
Manganese binding site 3 out of 4 in 4uma
Go back to
Manganese Binding Sites List in 4uma
Manganese binding site 3 out
of 4 in the Structural Analysis of Substrate-Mimicking Inhibitors in Complex with Neisseria Meningitidis 3 Deoxy D Arabino Heptulosonate 7 Phosphate Synthase the Importance of Accommodating the Active Site Water
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 3 of Structural Analysis of Substrate-Mimicking Inhibitors in Complex with Neisseria Meningitidis 3 Deoxy D Arabino Heptulosonate 7 Phosphate Synthase the Importance of Accommodating the Active Site Water within 5.0Å range:
|
Manganese binding site 4 out of 4 in 4uma
Go back to
Manganese Binding Sites List in 4uma
Manganese binding site 4 out
of 4 in the Structural Analysis of Substrate-Mimicking Inhibitors in Complex with Neisseria Meningitidis 3 Deoxy D Arabino Heptulosonate 7 Phosphate Synthase the Importance of Accommodating the Active Site Water
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 4 of Structural Analysis of Substrate-Mimicking Inhibitors in Complex with Neisseria Meningitidis 3 Deoxy D Arabino Heptulosonate 7 Phosphate Synthase the Importance of Accommodating the Active Site Water within 5.0Å range:
|
Reference:
L.C.Heyes,
S.Reichau,
P.J.Cross,
G.B.Jameson,
E.J.Parker.
Structural Analysis of Substrate-Mimicking Inhibitors in Complex with Neisseria Meningitidis 3-Deoxy-D-Arabino- Heptulosonate 7-Phosphate Synthase - the Importance of Accommodating the Active Site Water. Bioorg.Chem. 2014.
ISSN: ESSN 1090-2120
PubMed: 25245459
DOI: 10.1016/J.BIOORG.2014.08.003
Page generated: Sat Oct 5 21:20:49 2024
ISSN: ESSN 1090-2120
PubMed: 25245459
DOI: 10.1016/J.BIOORG.2014.08.003
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