Manganese in PDB 4qh9: Crystal Structure of MN2+ Bound Human APE1

All present enzymatic activity of Crystal Structure of MN2+ Bound Human APE1:
4.2.99.18;

The structure of Crystal Structure of MN2+ Bound Human APE1, PDB code: 4qh9 was solved by Q.Chen, H.He, M.M.Georgiadis, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.00 / 2.17
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	46.638, 140.490, 45.197, 90.00, 90.00, 90.00
R / Rfree (%)	19.6 / 25.6

The binding sites of Manganese atom in the Crystal Structure of MN2+ Bound Human APE1 (pdb code 4qh9). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Crystal Structure of MN2+ Bound Human APE1, PDB code: 4qh9:

Manganese binding site 1 out of 1 in the Crystal Structure of MN2+ Bound Human APE1


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Crystal Structure of MN2+ Bound Human APE1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn408 b:20.8 occ:1.00 OE2 A:GLU96 2.1 25.3 1.0 O A:HOH599 2.2 16.0 1.0 O A:HOH601 2.2 23.6 1.0 OD1 A:ASP70 2.3 17.7 1.0 O A:HOH600 2.3 18.4 1.0 O A:HOH598 2.4 8.7 1.0 CD A:GLU96 2.9 21.7 1.0 OE1 A:GLU96 3.0 25.5 1.0 CG A:ASP70 3.3 19.9 1.0 CB A:ASP70 3.9 11.1 1.0 OD1 A:ASP308 4.1 9.4 1.0 OD2 A:ASP308 4.1 13.8 1.0 CA A:ASP70 4.1 14.5 1.0 OD2 A:ASP70 4.2 12.6 1.0 NZ A:LYS98 4.2 30.8 1.0 CG A:GLU96 4.3 18.0 1.0 O A:HOH524 4.4 12.2 1.0 OD1 A:ASN68 4.5 12.0 1.0 CG A:ASP308 4.5 12.6 1.0 CE A:LYS98 4.6 17.1 1.0 O A:HOH624 4.9 24.1 1.0 O A:HOH602 5.0 27.0 1.0 N A:ASP70 5.0 10.9 1.0

H.He, Q.Chen, M.M.Georgiadis. High-Resolution Crystal Structures Reveal Plasticity in the Metal Binding Site of Apurinic/Apyrimidinic Endonuclease I. Biochemistry V. 53 6520 2014.
ISSN: ISSN 0006-2960
PubMed: 25251148
DOI: 10.1021/BI500676P