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Manganese in PDB 4p2h: Structure of Human Dna Polymerase Complexed with N7MG in the Template Opposite to Incoming Non-Hydrolyzable Ttp with Manganese in the Active Site
Enzymatic activity of Structure of Human Dna Polymerase Complexed with N7MG in the Template Opposite to Incoming Non-Hydrolyzable Ttp with Manganese in the Active Site
All present enzymatic activity of Structure of Human Dna Polymerase Complexed with N7MG in the Template Opposite to Incoming Non-Hydrolyzable Ttp with Manganese in the Active Site:
2.7.7.7;
2.7.7.7;
Protein crystallography data
The structure of Structure of Human Dna Polymerase Complexed with N7MG in the Template Opposite to Incoming Non-Hydrolyzable Ttp with Manganese in the Active Site, PDB code: 4p2h
was solved by
S.Lee,
M.C.Koag,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 19.79 / 1.99 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 54.767, 79.167, 54.982, 90.00, 106.18, 90.00 |
| R / Rfree (%) | 20.4 / 25 |
Other elements in 4p2h:
The structure of Structure of Human Dna Polymerase Complexed with N7MG in the Template Opposite to Incoming Non-Hydrolyzable Ttp with Manganese in the Active Site also contains other interesting chemical elements:
| Fluorine | (F) | 1 atom |
| Sodium | (Na) | 2 atoms |
Manganese Binding Sites:
The binding sites of Manganese atom in the Structure of Human Dna Polymerase Complexed with N7MG in the Template Opposite to Incoming Non-Hydrolyzable Ttp with Manganese in the Active Site
(pdb code 4p2h). This binding sites where shown within
5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the Structure of Human Dna Polymerase Complexed with N7MG in the Template Opposite to Incoming Non-Hydrolyzable Ttp with Manganese in the Active Site, PDB code: 4p2h:
Jump to Manganese binding site number: 1; 2;
In total 2 binding sites of Manganese where determined in the Structure of Human Dna Polymerase Complexed with N7MG in the Template Opposite to Incoming Non-Hydrolyzable Ttp with Manganese in the Active Site, PDB code: 4p2h:
Jump to Manganese binding site number: 1; 2;
Manganese binding site 1 out of 2 in 4p2h
Go back to
Manganese Binding Sites List in 4p2h
Manganese binding site 1 out
of 2 in the Structure of Human Dna Polymerase Complexed with N7MG in the Template Opposite to Incoming Non-Hydrolyzable Ttp with Manganese in the Active Site
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 1 of Structure of Human Dna Polymerase Complexed with N7MG in the Template Opposite to Incoming Non-Hydrolyzable Ttp with Manganese in the Active Site within 5.0Å range:
|
Manganese binding site 2 out of 2 in 4p2h
Go back to
Manganese Binding Sites List in 4p2h
Manganese binding site 2 out
of 2 in the Structure of Human Dna Polymerase Complexed with N7MG in the Template Opposite to Incoming Non-Hydrolyzable Ttp with Manganese in the Active Site
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 2 of Structure of Human Dna Polymerase Complexed with N7MG in the Template Opposite to Incoming Non-Hydrolyzable Ttp with Manganese in the Active Site within 5.0Å range:
|
Reference:
M.C.Koag,
Y.Kou,
H.Ouzon-Shubeita,
S.Lee.
Transition-State Destabilization Reveals How Human Dna Polymerase Beta Proceeds Across the Chemically Unstable Lesion N7-Methylguanine. Nucleic Acids Res. V. 42 8755 2014.
ISSN: ESSN 1362-4962
PubMed: 24966350
DOI: 10.1093/NAR/GKU554
Page generated: Sat Oct 5 20:43:49 2024
ISSN: ESSN 1362-4962
PubMed: 24966350
DOI: 10.1093/NAR/GKU554
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