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Manganese in PDB 4ny8: Dna Polymerase Beta with O6MG in the Template Base Opposite to Incoming Non-Hydrolyzable Ctp with Manganese in the Active Site
Enzymatic activity of Dna Polymerase Beta with O6MG in the Template Base Opposite to Incoming Non-Hydrolyzable Ctp with Manganese in the Active Site
All present enzymatic activity of Dna Polymerase Beta with O6MG in the Template Base Opposite to Incoming Non-Hydrolyzable Ctp with Manganese in the Active Site:
2.7.7.7;
2.7.7.7;
Protein crystallography data
The structure of Dna Polymerase Beta with O6MG in the Template Base Opposite to Incoming Non-Hydrolyzable Ctp with Manganese in the Active Site, PDB code: 4ny8
was solved by
M.-C.Koag,
K.Min,
A.F.Monzingo,
S.Lee,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 19.82 / 2.25 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 54.625, 79.288, 54.838, 90.00, 105.97, 90.00 |
| R / Rfree (%) | 20.6 / 26.5 |
Other elements in 4ny8:
The structure of Dna Polymerase Beta with O6MG in the Template Base Opposite to Incoming Non-Hydrolyzable Ctp with Manganese in the Active Site also contains other interesting chemical elements:
| Sodium | (Na) | 2 atoms |
Manganese Binding Sites:
The binding sites of Manganese atom in the Dna Polymerase Beta with O6MG in the Template Base Opposite to Incoming Non-Hydrolyzable Ctp with Manganese in the Active Site
(pdb code 4ny8). This binding sites where shown within
5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the Dna Polymerase Beta with O6MG in the Template Base Opposite to Incoming Non-Hydrolyzable Ctp with Manganese in the Active Site, PDB code: 4ny8:
Jump to Manganese binding site number: 1; 2;
In total 2 binding sites of Manganese where determined in the Dna Polymerase Beta with O6MG in the Template Base Opposite to Incoming Non-Hydrolyzable Ctp with Manganese in the Active Site, PDB code: 4ny8:
Jump to Manganese binding site number: 1; 2;
Manganese binding site 1 out of 2 in 4ny8
Go back to
Manganese Binding Sites List in 4ny8
Manganese binding site 1 out
of 2 in the Dna Polymerase Beta with O6MG in the Template Base Opposite to Incoming Non-Hydrolyzable Ctp with Manganese in the Active Site
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 1 of Dna Polymerase Beta with O6MG in the Template Base Opposite to Incoming Non-Hydrolyzable Ctp with Manganese in the Active Site within 5.0Å range:
|
Manganese binding site 2 out of 2 in 4ny8
Go back to
Manganese Binding Sites List in 4ny8
Manganese binding site 2 out
of 2 in the Dna Polymerase Beta with O6MG in the Template Base Opposite to Incoming Non-Hydrolyzable Ctp with Manganese in the Active Site
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 2 of Dna Polymerase Beta with O6MG in the Template Base Opposite to Incoming Non-Hydrolyzable Ctp with Manganese in the Active Site within 5.0Å range:
|
Reference:
M.C.Koag,
S.Lee.
Metal-Dependent Conformational Activation Explains Highly Promutagenic Replication Across O6-Methylguanine By Human Dna Polymerase Beta. J.Am.Chem.Soc. V. 136 5709 2014.
ISSN: ISSN 0002-7863
PubMed: 24694247
DOI: 10.1021/JA500172D
Page generated: Sat Oct 5 20:39:06 2024
ISSN: ISSN 0002-7863
PubMed: 24694247
DOI: 10.1021/JA500172D
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