Manganese in PDB 4nrq: Crystal Structure of Human ALKBH5 in Complex with Pyridine-2,4- Dicarboxylate

The structure of Crystal Structure of Human ALKBH5 in Complex with Pyridine-2,4- Dicarboxylate, PDB code: 4nrq was solved by C.Feng, Z.Chen, Y.Liu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 2.50
Space group	P 43 21 2
Cell size a, b, c (Å), α, β, γ (°)	56.767, 56.767, 144.706, 90.00, 90.00, 90.00
R / Rfree (%)	22.4 / 24.9

The binding sites of Manganese atom in the Crystal Structure of Human ALKBH5 in Complex with Pyridine-2,4- Dicarboxylate (pdb code 4nrq). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Crystal Structure of Human ALKBH5 in Complex with Pyridine-2,4- Dicarboxylate, PDB code: 4nrq:

Manganese binding site 1 out of 1 in the Crystal Structure of Human ALKBH5 in Complex with Pyridine-2,4- Dicarboxylate


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Crystal Structure of Human ALKBH5 in Complex with Pyridine-2,4- Dicarboxylate within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn302 b:16.1 occ:0.50 NE2 A:HIS266 2.1 28.1 1.0 O21 A:PD2301 2.1 31.1 1.0 OD1 A:ASP206 2.2 24.3 1.0 N1 A:PD2301 2.3 30.9 1.0 NE2 A:HIS204 2.5 32.5 1.0 O A:HOH401 2.7 28.7 1.0 C21 A:PD2301 2.9 28.0 1.0 CE1 A:HIS266 3.0 26.1 1.0 C2 A:PD2301 3.0 28.8 1.0 CD2 A:HIS266 3.2 26.0 1.0 CG A:ASP206 3.2 26.1 1.0 CE1 A:HIS204 3.2 31.7 1.0 C6 A:PD2301 3.3 32.0 1.0 CD2 A:HIS204 3.6 29.8 1.0 OD2 A:ASP206 3.6 26.8 1.0 O22 A:PD2301 4.1 28.4 1.0 ND1 A:HIS266 4.2 26.2 1.0 CG A:HIS266 4.3 24.9 1.0 C3 A:PD2301 4.4 31.1 1.0 ND1 A:HIS204 4.4 30.2 1.0 C5 A:PD2301 4.5 32.9 1.0 CB A:ASP206 4.5 24.9 1.0 CG A:HIS204 4.6 28.2 1.0 N A:ASP206 4.8 22.9 1.0 CA A:ASP206 4.9 23.4 1.0 C4 A:PD2301 5.0 32.1 1.0

C.Feng, Y.Liu, G.Wang, Z.Deng, Q.Zhang, W.Wu, Y.Tong, C.Cheng, Z.Chen. Crystal Structures of Human Rna Demethylase ALKBH5 Reveal Basis For Substrate Recognition J.Biol.Chem. 2014.
ISSN: ESSN 1083-351X
DOI: 10.1074/JBC.M113.546168