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Manganese in PDB 4dle: Ternary Structure of the Large Fragment of Taq Dna Polymerase: 4- Fluoroproline Variant

Enzymatic activity of Ternary Structure of the Large Fragment of Taq Dna Polymerase: 4- Fluoroproline Variant

All present enzymatic activity of Ternary Structure of the Large Fragment of Taq Dna Polymerase: 4- Fluoroproline Variant:
2.7.7.7;

Protein crystallography data

The structure of Ternary Structure of the Large Fragment of Taq Dna Polymerase: 4- Fluoroproline Variant, PDB code: 4dle was solved by B.Holzberger, S.Obeid, W.Welte, K.Diederichs, A.Marx, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 42.09 / 2.44
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 109.619, 109.619, 91.011, 90.00, 90.00, 120.00
R / Rfree (%) 23.3 / 28.2

Other elements in 4dle:

The structure of Ternary Structure of the Large Fragment of Taq Dna Polymerase: 4- Fluoroproline Variant also contains other interesting chemical elements:

Fluorine (F) 34 atoms
Magnesium (Mg) 1 atom

Manganese Binding Sites:

The binding sites of Manganese atom in the Ternary Structure of the Large Fragment of Taq Dna Polymerase: 4- Fluoroproline Variant (pdb code 4dle). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Ternary Structure of the Large Fragment of Taq Dna Polymerase: 4- Fluoroproline Variant, PDB code: 4dle:

Manganese binding site 1 out of 1 in 4dle

Go back to Manganese Binding Sites List in 4dle
Manganese binding site 1 out of 1 in the Ternary Structure of the Large Fragment of Taq Dna Polymerase: 4- Fluoroproline Variant


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Ternary Structure of the Large Fragment of Taq Dna Polymerase: 4- Fluoroproline Variant within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn904

b:38.8
occ:1.00
 O A:TYR611 2.0 44.9 1.0
O1G A:DCT903 2.1 43.8 1.0
OD2 A:ASP785 2.1 18.8 1.0
OD1 A:ASP610 2.2 62.0 1.0
O1B A:DCT903 2.2 22.5 1.0
O1A A:DCT903 2.4 31.5 1.0
CG A:ASP610 2.8 48.0 1.0
OD2 A:ASP610 3.1 44.0 1.0
C A:TYR611 3.2 36.0 1.0
CG A:ASP785 3.3 18.7 1.0
PB A:DCT903 3.3 21.7 1.0
PG A:DCT903 3.3 42.8 1.0
O A:HOH1013 3.4 11.4 1.0
PA A:DCT903 3.5 30.6 1.0
O3B A:DCT903 3.7 0.6 1.0
O3A A:DCT903 3.7 58.5 1.0
OD1 A:ASP785 3.8 17.5 1.0
MG A:MG901 3.9 34.8 1.0
N A:TYR611 3.9 18.2 1.0
O5' A:DCT903 3.9 27.6 1.0
O2G A:DCT903 4.0 46.6 1.0
CB A:ASP610 4.0 37.5 1.0
CA A:TYR611 4.0 21.4 1.0
N A:SER612 4.0 40.7 1.0
C A:ASP610 4.2 24.2 1.0
CA A:SER612 4.2 43.8 1.0
N A:GLN613 4.3 33.9 1.0
CG2 A:ILE614 4.4 14.6 1.0
CB A:ASP785 4.5 15.9 1.0
O3G A:DCT903 4.5 52.4 1.0
CB A:TYR611 4.6 22.1 1.0
C5' A:DCT903 4.6 22.6 1.0
CA A:ASP610 4.6 27.2 1.0
C A:SER612 4.6 41.1 1.0
O A:ASP610 4.6 25.4 1.0
O2B A:DCT903 4.6 30.3 1.0
N A:ILE614 4.8 30.0 1.0
O A:HOH1006 4.8 47.6 1.0
O2A A:DCT903 4.8 33.1 1.0
O A:ASP785 4.9 25.1 1.0
O A:HOH1054 5.0 32.0 1.0
CB A:ILE614 5.0 16.3 1.0

Reference:

B.Holzberger, S.Obeid, W.Welte, K.Diederichs, A.Marx. Structural Insights Into the Potential of 4-Fluoroproline to Modulate Biophysical Properties of Protein Chem Sci V. 3 2924 2012.
ISSN: ISSN 2041-6520
DOI: 10.1039/C2SC20545A
Page generated: Tue Dec 15 04:19:19 2020

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