Atomistry » Manganese » PDB 4b5i-4dec » 4c2s
Atomistry »
  Manganese »
    PDB 4b5i-4dec »
      4c2s »

Manganese in PDB 4c2s: Crystal Structure of the Fucosylgalactoside Alpha N- Acetylgalactosaminyltransferase (Gta P156L Mutant) in Complex with Udp and Deoxy-H-Antigen Acceptor

Enzymatic activity of Crystal Structure of the Fucosylgalactoside Alpha N- Acetylgalactosaminyltransferase (Gta P156L Mutant) in Complex with Udp and Deoxy-H-Antigen Acceptor

All present enzymatic activity of Crystal Structure of the Fucosylgalactoside Alpha N- Acetylgalactosaminyltransferase (Gta P156L Mutant) in Complex with Udp and Deoxy-H-Antigen Acceptor:
2.4.1.37; 2.4.1.40;

Protein crystallography data

The structure of Crystal Structure of the Fucosylgalactoside Alpha N- Acetylgalactosaminyltransferase (Gta P156L Mutant) in Complex with Udp and Deoxy-H-Antigen Acceptor, PDB code: 4c2s was solved by J.T.Weadge, M.Palcic, A.Henriksen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 36.88 / 2.48
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 147.510, 52.610, 80.270, 90.00, 89.97, 90.00
R / Rfree (%) 14.503 / 18.203

Manganese Binding Sites:

The binding sites of Manganese atom in the Crystal Structure of the Fucosylgalactoside Alpha N- Acetylgalactosaminyltransferase (Gta P156L Mutant) in Complex with Udp and Deoxy-H-Antigen Acceptor (pdb code 4c2s). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the Crystal Structure of the Fucosylgalactoside Alpha N- Acetylgalactosaminyltransferase (Gta P156L Mutant) in Complex with Udp and Deoxy-H-Antigen Acceptor, PDB code: 4c2s:
Jump to Manganese binding site number: 1; 2;

Manganese binding site 1 out of 2 in 4c2s

Go back to Manganese Binding Sites List in 4c2s
Manganese binding site 1 out of 2 in the Crystal Structure of the Fucosylgalactoside Alpha N- Acetylgalactosaminyltransferase (Gta P156L Mutant) in Complex with Udp and Deoxy-H-Antigen Acceptor


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Crystal Structure of the Fucosylgalactoside Alpha N- Acetylgalactosaminyltransferase (Gta P156L Mutant) in Complex with Udp and Deoxy-H-Antigen Acceptor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn406

b:12.2
occ:1.00
O1B A:UDP475 1.9 8.6 1.0
OD2 A:ASP211 2.0 11.1 1.0
OD1 A:ASP213 2.2 10.9 1.0
O1A A:UDP475 2.3 7.0 1.0
OD2 A:ASP213 2.6 10.5 1.0
CG A:ASP213 2.7 10.9 1.0
PB A:UDP475 3.1 8.9 1.0
CG A:ASP211 3.1 10.6 1.0
O3A A:UDP475 3.5 8.0 1.0
PA A:UDP475 3.5 6.8 1.0
CB A:ASP211 3.6 9.9 1.0
O3B A:UDP475 3.8 9.1 1.0
O3' A:UDP475 3.9 2.0 1.0
NZ A:LYS346 4.0 12.3 1.0
OD1 A:ASP211 4.2 11.2 1.0
CB A:ASP213 4.2 10.5 1.0
O2B A:UDP475 4.2 9.6 1.0
C5' A:UDP475 4.3 4.2 1.0
O5' A:UDP475 4.4 5.0 1.0
O2A A:UDP475 4.6 6.9 1.0
C3' A:UDP475 4.6 3.0 1.0
CE A:LYS346 4.8 12.7 1.0
SD A:MET214 4.9 11.4 1.0
N A:ASP213 4.9 10.4 1.0
O A:ASP213 4.9 10.7 1.0
C4' A:UDP475 4.9 3.6 1.0
CA A:ASP211 5.0 8.8 1.0
CA A:ASP213 5.0 10.7 1.0

Manganese binding site 2 out of 2 in 4c2s

Go back to Manganese Binding Sites List in 4c2s
Manganese binding site 2 out of 2 in the Crystal Structure of the Fucosylgalactoside Alpha N- Acetylgalactosaminyltransferase (Gta P156L Mutant) in Complex with Udp and Deoxy-H-Antigen Acceptor


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Crystal Structure of the Fucosylgalactoside Alpha N- Acetylgalactosaminyltransferase (Gta P156L Mutant) in Complex with Udp and Deoxy-H-Antigen Acceptor within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mn406

b:14.5
occ:1.00
O1B B:UDP475 1.9 9.9 1.0
OD2 B:ASP211 2.0 9.8 1.0
O1A B:UDP475 2.0 10.4 1.0
OD1 B:ASP213 2.2 10.6 1.0
OD2 B:ASP213 2.9 8.4 1.0
CG B:ASP213 2.9 9.4 1.0
CG B:ASP211 3.0 9.5 1.0
PB B:UDP475 3.1 10.1 1.0
PA B:UDP475 3.3 10.8 1.0
O3A B:UDP475 3.4 10.9 1.0
CB B:ASP211 3.5 9.3 1.0
O3' B:UDP475 4.0 8.0 1.0
OD1 B:ASP211 4.0 10.3 1.0
O3B B:UDP475 4.1 10.3 1.0
O2A B:UDP475 4.1 10.3 1.0
NZ B:LYS346 4.2 15.1 1.0
O2B B:UDP475 4.2 10.2 1.0
CB B:ASP213 4.3 8.9 1.0
O5' B:UDP475 4.4 9.8 1.0
O B:HOH2028 4.5 14.5 1.0
C5' B:UDP475 4.6 9.4 1.0
C3' B:UDP475 4.8 8.8 1.0
CE B:LYS346 4.8 15.1 1.0
CA B:ASP211 4.9 8.3 1.0
N B:ASP213 5.0 8.4 1.0
SD B:MET214 5.0 11.4 1.0

Reference:

J.T.Weadge, M.Palcic, A.Henriksen. Structural and Biochemical Characterization of the Human Blood Group A and B Galactosyltransferases Posessing the PRO156LEU Mutation To Be Published.
Page generated: Sat Oct 5 18:53:24 2024

Last articles

Zn in 9J0N
Zn in 9J0O
Zn in 9J0P
Zn in 9FJX
Zn in 9EKB
Zn in 9C0F
Zn in 9CAH
Zn in 9CH0
Zn in 9CH3
Zn in 9CH1
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy