Manganese in PDB 4bqw: Hif Prolyl Hydroxylase 2 (PHD2/ EGLN1) in Complex with Mn(II) and 2- (4-Hydroxy-2-Oxo-1,2-Dihydroquinoline-3-Carboxamido)Acetic Acid

The structure of Hif Prolyl Hydroxylase 2 (PHD2/ EGLN1) in Complex with Mn(II) and 2- (4-Hydroxy-2-Oxo-1,2-Dihydroquinoline-3-Carboxamido)Acetic Acid, PDB code: 4bqw was solved by R.Chowdhury, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	23.80 / 1.79
Space group	P 63
Cell size a, b, c (Å), α, β, γ (°)	109.914, 109.914, 39.409, 90.00, 90.00, 120.00
R / Rfree (%)	19.5 / 20.1

The binding sites of Manganese atom in the Hif Prolyl Hydroxylase 2 (PHD2/ EGLN1) in Complex with Mn(II) and 2- (4-Hydroxy-2-Oxo-1,2-Dihydroquinoline-3-Carboxamido)Acetic Acid (pdb code 4bqw). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Hif Prolyl Hydroxylase 2 (PHD2/ EGLN1) in Complex with Mn(II) and 2- (4-Hydroxy-2-Oxo-1,2-Dihydroquinoline-3-Carboxamido)Acetic Acid, PDB code: 4bqw:

Manganese binding site 1 out of 1 in the Hif Prolyl Hydroxylase 2 (PHD2/ EGLN1) in Complex with Mn(II) and 2- (4-Hydroxy-2-Oxo-1,2-Dihydroquinoline-3-Carboxamido)Acetic Acid


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Hif Prolyl Hydroxylase 2 (PHD2/ EGLN1) in Complex with Mn(II) and 2- (4-Hydroxy-2-Oxo-1,2-Dihydroquinoline-3-Carboxamido)Acetic Acid within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn501 b:22.1 occ:1.00 OAU A:QNM901 2.0 24.6 1.0 O2 A:QNM901 2.1 18.9 1.0 NE2 A:HIS374 2.2 21.9 1.0 O A:HOH2117 2.2 18.9 1.0 OD1 A:ASP315 2.2 21.0 1.0 NE2 A:HIS313 2.3 22.0 1.0 CE1 A:HIS313 3.1 23.7 1.0 C2 A:QNM901 3.1 21.8 1.0 CE1 A:HIS374 3.1 21.8 1.0 CAT A:QNM901 3.2 22.9 1.0 CG A:ASP315 3.2 23.4 1.0 CD2 A:HIS374 3.2 21.1 1.0 CD2 A:HIS313 3.4 23.8 1.0 OD2 A:ASP315 3.5 22.3 1.0 CA0 A:QNM901 3.6 20.8 1.0 O A:HOH2161 4.1 22.2 1.0 N3 A:QNM901 4.2 20.4 1.0 ND1 A:HIS313 4.3 22.8 1.0 ND1 A:HIS374 4.3 21.9 1.0 CG A:HIS374 4.3 21.1 1.0 CAS A:QNM901 4.4 21.9 1.0 CG A:HIS313 4.4 23.0 1.0 CB A:ASP315 4.6 22.7 1.0 C4 A:QNM901 4.7 20.1 1.0 CAR A:QNM901 4.7 24.7 1.0 CZ A:PHE366 4.9 22.3 1.0 CA A:ASP315 4.9 23.5 1.0 C6 A:QNM901 5.0 21.0 1.0

R.Chowdhury, J.I.Candela-Lena, M.C.Chan, D.J.Greenald, K.K.Yeoh, Y.M.Tian, M.A.Mcdonough, A.Tumber, N.R.Rose, A.Conejo-Garcia, M.Demetriades, S.Mathavan, A.Kawamura, M.K.Lee, F.Van Eeden, C.W.Pugh, P.J.Ratcliffe, C.J.Schofield. Selective Small Molecule Probes For the Hypoxia Inducible Factor (Hif) Prolyl Hydroxylases. Acs Chem. Biol. V. 8 1488 2013.
ISSN: ESSN 1554-8937
PubMed: 23683440
DOI: 10.1021/CB400088Q