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Manganese in PDB 3thp: Crystal Structure and Rna Binding Properties of the Rrm/Alkb Domains in Human ABH8, An Enzyme Catalyzing Trna Hypermodification, Northeast Structural Genomics Consortium Target HR5601B

Protein crystallography data

The structure of Crystal Structure and Rna Binding Properties of the Rrm/Alkb Domains in Human ABH8, An Enzyme Catalyzing Trna Hypermodification, Northeast Structural Genomics Consortium Target HR5601B, PDB code: 3thp was solved by C.Pastore, I.Topalidou, F.Forouhar, A.C.Yan, M.Levy, J.F.Hunt, Northeaststructural Genomics Consortium (Nesg), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 35.57 / 3.20
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 68.276, 81.675, 144.720, 90.00, 90.00, 90.00
R / Rfree (%) 21.7 / 28.3

Other elements in 3thp:

The structure of Crystal Structure and Rna Binding Properties of the Rrm/Alkb Domains in Human ABH8, An Enzyme Catalyzing Trna Hypermodification, Northeast Structural Genomics Consortium Target HR5601B also contains other interesting chemical elements:

Zinc (Zn) 1 atom

Manganese Binding Sites:

The binding sites of Manganese atom in the Crystal Structure and Rna Binding Properties of the Rrm/Alkb Domains in Human ABH8, An Enzyme Catalyzing Trna Hypermodification, Northeast Structural Genomics Consortium Target HR5601B (pdb code 3thp). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Crystal Structure and Rna Binding Properties of the Rrm/Alkb Domains in Human ABH8, An Enzyme Catalyzing Trna Hypermodification, Northeast Structural Genomics Consortium Target HR5601B, PDB code: 3thp:

Manganese binding site 1 out of 1 in 3thp

Go back to Manganese Binding Sites List in 3thp
Manganese binding site 1 out of 1 in the Crystal Structure and Rna Binding Properties of the Rrm/Alkb Domains in Human ABH8, An Enzyme Catalyzing Trna Hypermodification, Northeast Structural Genomics Consortium Target HR5601B


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Crystal Structure and Rna Binding Properties of the Rrm/Alkb Domains in Human ABH8, An Enzyme Catalyzing Trna Hypermodification, Northeast Structural Genomics Consortium Target HR5601B within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn402

b:15.0
occ:1.00
NE2 A:HIS238 2.3 36.8 1.0
OD2 A:ASP240 2.4 33.5 1.0
O2 A:AKG403 2.4 55.6 1.0
NE2 A:HIS292 2.6 35.0 1.0
O5 A:AKG403 2.8 52.6 1.0
CE1 A:HIS238 3.0 36.9 1.0
C2 A:AKG403 3.1 52.5 1.0
C1 A:AKG403 3.1 54.5 1.0
CG A:ASP240 3.2 33.7 1.0
CD2 A:HIS292 3.4 32.2 1.0
OD1 A:ASP240 3.4 33.8 1.0
CD2 A:HIS238 3.4 37.7 1.0
CE1 A:HIS292 3.6 34.1 1.0
C3 A:AKG403 4.1 48.7 1.0
ND1 A:HIS238 4.1 37.3 1.0
O1 A:AKG403 4.3 56.0 1.0
CG A:HIS238 4.4 36.7 1.0
CG A:HIS292 4.6 30.9 1.0
CB A:ASP240 4.6 33.1 1.0
ND1 A:HIS292 4.7 32.5 1.0
NH2 A:ARG334 4.7 26.7 1.0
N A:ASP240 4.7 35.2 1.0

Reference:

C.Pastore, I.Topalidou, F.Forouhar, A.C.Yan, M.Levy, J.F.Hunt. Crystal Structure and Rna Binding Properties of the Rna Recognition Motif (Rrm) and Alkb Domains in Human Alkb Homolog 8 (ABH8), An Enzyme Catalyzing Trna Hypermodification. J.Biol.Chem. V. 287 2130 2012.
ISSN: ISSN 0021-9258
PubMed: 22065580
DOI: 10.1074/JBC.M111.286187
Page generated: Tue Dec 15 04:15:44 2020

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