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Atomistry » Manganese » PDB 3q7c-3rl4 » 3qlh | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Manganese » PDB 3q7c-3rl4 » 3qlh » |
Manganese in PDB 3qlh: Hiv-1 Reverse Transcriptase in Complex with Manicol at the Rnase H Active Site and TMC278 (Rilpivirine) at the Nnrti Binding PocketEnzymatic activity of Hiv-1 Reverse Transcriptase in Complex with Manicol at the Rnase H Active Site and TMC278 (Rilpivirine) at the Nnrti Binding Pocket
All present enzymatic activity of Hiv-1 Reverse Transcriptase in Complex with Manicol at the Rnase H Active Site and TMC278 (Rilpivirine) at the Nnrti Binding Pocket:
2.7.7.49; 2.7.7.7; 3.1.26.13; Protein crystallography data
The structure of Hiv-1 Reverse Transcriptase in Complex with Manicol at the Rnase H Active Site and TMC278 (Rilpivirine) at the Nnrti Binding Pocket, PDB code: 3qlh
was solved by
D.M.Himmel,
K.Wojtak,
J.D.Bauman,
E.Arnold,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Manganese Binding Sites:
The binding sites of Manganese atom in the Hiv-1 Reverse Transcriptase in Complex with Manicol at the Rnase H Active Site and TMC278 (Rilpivirine) at the Nnrti Binding Pocket
(pdb code 3qlh). This binding sites where shown within
5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the Hiv-1 Reverse Transcriptase in Complex with Manicol at the Rnase H Active Site and TMC278 (Rilpivirine) at the Nnrti Binding Pocket, PDB code: 3qlh: Jump to Manganese binding site number: 1; 2; Manganese binding site 1 out of 2 in 3qlhGo back to Manganese Binding Sites List in 3qlh
Manganese binding site 1 out
of 2 in the Hiv-1 Reverse Transcriptase in Complex with Manicol at the Rnase H Active Site and TMC278 (Rilpivirine) at the Nnrti Binding Pocket
Mono view Stereo pair view
Manganese binding site 2 out of 2 in 3qlhGo back to Manganese Binding Sites List in 3qlh
Manganese binding site 2 out
of 2 in the Hiv-1 Reverse Transcriptase in Complex with Manicol at the Rnase H Active Site and TMC278 (Rilpivirine) at the Nnrti Binding Pocket
Mono view Stereo pair view
Reference:
S.Chung,
D.M.Himmel,
J.K.Jiang,
K.Wojtak,
J.D.Bauman,
J.W.Rausch,
J.A.Wilson,
J.A.Beutler,
C.J.Thomas,
E.Arnold,
S.F.Le Grice.
Synthesis, Activity, and Structural Analysis of Novel Alpha-Hydroxytropolone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H. J.Med.Chem. V. 54 4462 2011.
Page generated: Sat Oct 5 17:41:37 2024
ISSN: ISSN 0022-2623 PubMed: 21568335 DOI: 10.1021/JM2000757 |
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