Manganese in PDB 3q7c: Exonuclease Domain of Lassa Virus Nucleoprotein Bound to Manganese

The structure of Exonuclease Domain of Lassa Virus Nucleoprotein Bound to Manganese, PDB code: 3q7c was solved by K.M.Hastie, C.R.Kimberlin, M.A.Zandonatti, I.J.Macrae, E.O.Saphire, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	33.81 / 1.50
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	44.870, 67.940, 78.680, 90.00, 90.00, 90.00
R / Rfree (%)	19 / 21.6

The structure of Exonuclease Domain of Lassa Virus Nucleoprotein Bound to Manganese also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

The binding sites of Manganese atom in the Exonuclease Domain of Lassa Virus Nucleoprotein Bound to Manganese (pdb code 3q7c). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Exonuclease Domain of Lassa Virus Nucleoprotein Bound to Manganese, PDB code: 3q7c:

Manganese binding site 1 out of 1 in the Exonuclease Domain of Lassa Virus Nucleoprotein Bound to Manganese


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Exonuclease Domain of Lassa Virus Nucleoprotein Bound to Manganese within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn2 b:19.3 occ:0.38 OD2 A:ASP533 1.8 19.8 1.0 OD2 A:ASP389 2.0 14.8 1.0 O A:HOH208 2.1 14.0 1.0 OE2 A:GLU391 2.2 24.0 1.0 CG A:ASP533 2.9 16.3 1.0 O A:HOH114 3.0 23.4 1.0 CG A:ASP389 3.0 17.4 1.0 O A:HOH261 3.2 28.9 1.0 CD A:GLU391 3.3 18.8 1.0 OD1 A:ASP389 3.3 18.1 1.0 O A:ILE390 3.5 11.6 1.0 O A:HOH69 3.5 32.8 1.0 CB A:ASP533 3.6 10.3 1.0 OD1 A:ASP533 3.9 14.3 1.0 OE1 A:GLU391 4.0 23.7 1.0 CA A:ALA530 4.2 8.3 1.0 O A:CYS529 4.2 10.4 1.0 O A:HOH282 4.3 31.0 1.0 CB A:ASP389 4.3 10.6 1.0 CG A:GLU391 4.3 12.6 1.0 C A:ILE390 4.4 9.6 1.0 O A:HOH20 4.5 19.9 1.0 C A:CYS529 4.5 8.5 1.0 N A:ALA530 4.5 8.3 1.0 N A:ILE390 4.7 9.5 1.0 CB A:HIS528 4.7 12.4 1.0 CB A:ALA530 4.9 9.3 1.0 O A:HOH166 5.0 33.7 1.0

K.M.Hastie, C.R.Kimberlin, M.A.Zandonatti, I.J.Macrae, E.O.Saphire. Structure of the Lassa Virus Nucleoprotein Reveals A Dsrna-Specific 3' to 5' Exonuclease Activity Essential For Immune Suppression. Proc.Natl.Acad.Sci.Usa V. 108 2396 2011.
ISSN: ISSN 0027-8424
PubMed: 21262835
DOI: 10.1073/PNAS.1016404108