Manganese in PDB 2qzy: The Structure of Chicken Mitochondrial Pepck in Complex with Pep

All present enzymatic activity of The Structure of Chicken Mitochondrial Pepck in Complex with Pep:
4.1.1.32;

The structure of The Structure of Chicken Mitochondrial Pepck in Complex with Pep, PDB code: 2qzy was solved by T.Holyoak, S.M.Sullivan, T.Nowak, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	35.09 / 1.90
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	110.349, 48.023, 126.317, 90.00, 111.39, 90.00
R / Rfree (%)	16.1 / 20

The binding sites of Manganese atom in the The Structure of Chicken Mitochondrial Pepck in Complex with Pep (pdb code 2qzy). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the The Structure of Chicken Mitochondrial Pepck in Complex with Pep, PDB code: 2qzy:
Jump to Manganese binding site number: 1; 2;

Manganese binding site 1 out of 2 in the The Structure of Chicken Mitochondrial Pepck in Complex with Pep


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of The Structure of Chicken Mitochondrial Pepck in Complex with Pep within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn1101 b:8.5 occ:1.00 NZ A:LYS263 2.0 16.6 1.0 OD1 A:ASP330 2.0 17.9 1.0 O A:HOH1602 2.1 17.1 1.0 NE2 A:HIS283 2.2 17.5 1.0 O A:HOH1601 2.3 22.5 1.0 O A:HOH1228 2.3 13.6 1.0 CG A:ASP330 3.0 16.0 1.0 CD2 A:HIS283 3.1 15.1 1.0 CE1 A:HIS283 3.1 18.0 1.0 CE A:LYS263 3.2 17.5 1.0 OD2 A:ASP330 3.2 18.3 1.0 O1P A:PEP1102 4.2 12.6 0.8 O A:HOH1337 4.2 29.8 1.0 ND1 A:HIS283 4.2 16.0 1.0 CG A:HIS283 4.2 15.9 1.0 O2P A:PEP1102 4.3 11.9 0.8 O A:HOH1317 4.3 25.7 1.0 O A:HOH1479 4.4 29.8 1.0 O A:HOH1600 4.4 35.3 1.0 CB A:ASP330 4.4 15.2 1.0 NZ A:LYS309 4.4 32.8 1.0 CD A:LYS263 4.5 16.8 1.0 P A:PEP1102 4.8 14.8 0.8 O A:ASP330 4.9 16.2 1.0 CA A:ASP330 4.9 15.5 1.0 CE2 A:PHE504 4.9 15.8 1.0 CZ A:PHE504 5.0 15.5 1.0

Manganese binding site 2 out of 2 in the The Structure of Chicken Mitochondrial Pepck in Complex with Pep


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of The Structure of Chicken Mitochondrial Pepck in Complex with Pep within 5.0Å range: probe atom residue distance (Å) B Occ B:Mn1201 b:15.1 occ:1.00 O B:HOH1226 1.9 20.3 1.0 NZ B:LYS263 1.9 14.0 1.0 OD1 B:ASP330 2.1 15.6 1.0 NE2 B:HIS283 2.1 13.8 1.0 O B:HOH1553 2.3 23.7 1.0 O B:HOH1552 2.3 22.2 1.0 CG B:ASP330 3.0 17.3 1.0 CD2 B:HIS283 3.1 14.7 1.0 CE1 B:HIS283 3.1 14.5 1.0 CE B:LYS263 3.1 17.2 1.0 OD2 B:ASP330 3.2 17.9 1.0 ND1 B:HIS283 4.2 14.8 1.0 O1P B:PEP1202 4.2 24.2 0.9 CG B:HIS283 4.2 15.5 1.0 NZ B:LYS309 4.3 23.1 1.0 O2P B:PEP1202 4.3 22.0 0.9 CD B:LYS263 4.4 18.1 1.0 CB B:ASP330 4.4 16.2 1.0 O B:HOH1438 4.7 35.2 1.0 P B:PEP1202 4.8 23.7 0.9 CZ B:PHE504 4.8 17.1 1.0 CE2 B:PHE504 4.9 17.2 1.0 O B:ASP330 4.9 16.3 1.0 CA B:ASP330 5.0 16.3 1.0

T.Holyoak, S.M.Sullivan, T.Nowak. Structural Insights Into the Mechanism of Pepck Catalysis Biochemistry V. 45 8254 2006.
ISSN: ISSN 0006-2960
PubMed: 16819824
DOI: 10.1021/BI060269G