Manganese in PDB 2p99: E. Coli Methionine Aminopeptidase Monometalated with Inhibitor YE6

Enzymatic activity of E. Coli Methionine Aminopeptidase Monometalated with Inhibitor YE6

All present enzymatic activity of E. Coli Methionine Aminopeptidase Monometalated with Inhibitor YE6:
3.4.11.18;

Protein crystallography data

The structure of E. Coli Methionine Aminopeptidase Monometalated with Inhibitor YE6, PDB code: 2p99 was solved by Q.Ye, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	20.00 / 1.80
*Space group*	P 1 2₁ 1
*Cell size a, b, c (Å), α, β, γ (°)*	38.310, 61.700, 50.640, 90.00, 105.43, 90.00
*R / R_free (%)*	22.7 / 26.3

Other elements in 2p99:

The structure of E. Coli Methionine Aminopeptidase Monometalated with Inhibitor YE6 also contains other interesting chemical elements:

Chlorine	(Cl)	1 atom
Sodium	(Na)	1 atom

Manganese Binding Sites:

The binding sites of Manganese atom in the E. Coli Methionine Aminopeptidase Monometalated with Inhibitor YE6 (pdb code 2p99). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the E. Coli Methionine Aminopeptidase Monometalated with Inhibitor YE6, PDB code: 2p99:

Manganese binding site 1 out of 1 in 2p99

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Manganese Binding Sites List in 2p99

Manganese binding site 1 out of 1 in the E. Coli Methionine Aminopeptidase Monometalated with Inhibitor YE6

Mono view

Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of E. Coli Methionine Aminopeptidase Monometalated with Inhibitor YE6 within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Mn263 b:17.1 occ:1.00	OD2	A:ASP108	2.2	15.0	1.0
	OE2	A:GLU204	2.2	16.8	1.0
	OE2	A:GLU235	2.3	13.6	1.0
	OAO	A:YE6265	2.3	27.4	1.0
	NE2	A:HIS171	2.3	13.7	1.0
	NAM	A:YE6265	2.4	23.5	1.0
	CAE	A:YE6265	3.0	26.5	1.0
	NAL	A:YE6265	3.1	24.9	1.0
	CG	A:ASP108	3.1	15.1	1.0
	CD	A:GLU204	3.2	17.7	1.0
	CE1	A:HIS171	3.2	16.9	1.0
	CD	A:GLU235	3.3	15.3	1.0
	CD2	A:HIS171	3.3	14.0	1.0
	OE1	A:GLU204	3.5	17.4	1.0
	OE1	A:GLU235	3.6	16.7	1.0
	OD1	A:ASP108	3.7	16.2	1.0
	OG1	A:THR202	3.8	15.7	1.0
	CG2	A:THR202	4.2	13.3	1.0
	CB	A:ASP108	4.2	14.7	1.0
	CB	A:THR202	4.3	14.6	1.0
	ND1	A:HIS171	4.3	13.2	1.0
	CG	A:HIS171	4.4	16.2	1.0
	CG	A:GLU204	4.5	17.1	1.0
	CAA	A:YE6265	4.5	28.1	1.0
	CG	A:GLU235	4.6	11.4	1.0
	NE2	A:HIS178	4.6	20.8	1.0
	CE1	A:PHE177	4.7	23.5	1.0
	O	A:HOH390	4.9	12.7	1.0
	CD2	A:HIS178	4.9	24.1	1.0

Reference:

M.Huang, S.X.Xie, Z.Q.Ma, Q.Q.Huang, F.J.Nan, Q.Z.Ye. Inhibition of Monometalated Methionine Aminopeptidase: Inhibitor Discovery and Crystallographic Analysis. J.Med.Chem. V. 50 5735 2007.
ISSN: ISSN 0022-2623
PubMed: 17948983
DOI: 10.1021/JM700930K

Page generated: Tue Dec 15 04:04:23 2020

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