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Manganese in PDB 2nym: Crystal Structure of Protein Phosphatase 2A (PP2A) with C-Terminus Truncated Catalytic Subunit

Enzymatic activity of Crystal Structure of Protein Phosphatase 2A (PP2A) with C-Terminus Truncated Catalytic Subunit

All present enzymatic activity of Crystal Structure of Protein Phosphatase 2A (PP2A) with C-Terminus Truncated Catalytic Subunit:
3.1.3.16;

Protein crystallography data

The structure of Crystal Structure of Protein Phosphatase 2A (PP2A) with C-Terminus Truncated Catalytic Subunit, PDB code: 2nym was solved by Y.Chen, Y.Xing, Y.Xu, Y.Chao, Z.Lin, P.D.Jeffrey, Y.Shi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 100.00 / 3.60
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 108.170, 158.860, 270.750, 90.00, 90.00, 90.00
R / Rfree (%) 26.7 / 33.1

Manganese Binding Sites:

The binding sites of Manganese atom in the Crystal Structure of Protein Phosphatase 2A (PP2A) with C-Terminus Truncated Catalytic Subunit (pdb code 2nym). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 4 binding sites of Manganese where determined in the Crystal Structure of Protein Phosphatase 2A (PP2A) with C-Terminus Truncated Catalytic Subunit, PDB code: 2nym:
Jump to Manganese binding site number: 1; 2; 3; 4;

Manganese binding site 1 out of 4 in 2nym

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Manganese binding site 1 out of 4 in the Crystal Structure of Protein Phosphatase 2A (PP2A) with C-Terminus Truncated Catalytic Subunit


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Crystal Structure of Protein Phosphatase 2A (PP2A) with C-Terminus Truncated Catalytic Subunit within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Mn501

b:23.7
occ:1.00
OD1 C:ASN117 2.0 24.5 1.0
ND1 C:HIS241 2.1 64.8 1.0
NE2 C:HIS167 2.1 21.9 1.0
OD2 C:ASP85 2.2 50.7 1.0
CE1 C:HIS167 2.5 25.7 1.0
CE1 C:HIS241 2.7 72.7 1.0
CG C:ASN117 2.7 25.1 1.0
CG C:ASP85 2.8 47.0 1.0
MN C:MN502 2.9 60.0 1.0
ND2 C:ASN117 2.9 5.5 1.0
OD1 C:ASP85 2.9 38.8 1.0
CG C:HIS241 3.4 66.8 1.0
OD2 C:ASP57 3.4 50.4 1.0
CD2 C:HIS167 3.4 29.2 1.0
O C:HIS241 3.8 52.5 1.0
ND1 C:HIS167 3.8 34.7 1.0
CA C:HIS241 4.0 50.8 1.0
CB C:HIS241 4.0 58.2 1.0
NE2 C:HIS241 4.0 70.0 1.0
CD2 C:HIS118 4.2 45.2 1.0
CB C:ASN117 4.2 26.8 1.0
CB C:ASP85 4.2 50.0 1.0
CG C:ASP57 4.3 46.9 1.0
CG C:HIS167 4.3 37.3 1.0
CD2 C:HIS241 4.3 68.3 1.0
C C:HIS241 4.3 48.7 1.0
OD1 C:ASP57 4.4 42.5 1.0
N C:ASN117 4.6 43.4 1.0
NE2 C:HIS59 4.6 52.2 1.0
NE2 C:HIS118 4.8 46.8 1.0
OXT G:FGA6 4.8 95.7 1.0
CE1 C:HIS59 4.9 47.9 1.0
CA C:ASN117 5.0 39.6 1.0

Manganese binding site 2 out of 4 in 2nym

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Manganese binding site 2 out of 4 in the Crystal Structure of Protein Phosphatase 2A (PP2A) with C-Terminus Truncated Catalytic Subunit


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Crystal Structure of Protein Phosphatase 2A (PP2A) with C-Terminus Truncated Catalytic Subunit within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Mn502

b:60.0
occ:1.00
OD2 C:ASP85 2.0 50.7 1.0
OD2 C:ASP57 2.2 50.4 1.0
NE2 C:HIS59 2.3 52.2 1.0
MN C:MN501 2.9 23.7 1.0
CE1 C:HIS59 3.2 47.9 1.0
CG C:ASP85 3.2 47.0 1.0
OXT G:FGA6 3.3 95.7 1.0
CD2 C:HIS59 3.4 48.1 1.0
CG C:ASP57 3.4 46.9 1.0
OH C:TYR265 3.7 27.4 1.0
CE1 C:PHE260 4.0 45.3 1.0
CB C:ASP85 4.1 50.0 1.0
OD1 C:ASP85 4.2 38.8 1.0
O C:HIS241 4.3 52.5 1.0
CB C:ASP57 4.3 45.2 1.0
OD1 C:ASP57 4.3 42.5 1.0
ND1 C:HIS59 4.3 42.8 1.0
C G:FGA6 4.4 91.2 1.0
CD2 C:HIS118 4.4 45.2 1.0
NE2 C:HIS118 4.4 46.8 1.0
ND1 C:HIS241 4.4 64.8 1.0
CE1 C:HIS167 4.5 25.7 1.0
CG C:HIS59 4.5 42.8 1.0
CZ C:PHE260 4.5 45.3 1.0
CZ C:TYR265 4.5 31.6 1.0
O G:FGA6 4.6 93.2 1.0
OD1 C:ASN117 4.6 24.5 1.0
ND2 C:ASN117 4.7 5.5 1.0
NE2 C:HIS167 4.7 21.9 1.0
C C:HIS241 4.7 48.7 1.0
CA C:HIS241 4.9 50.8 1.0

Manganese binding site 3 out of 4 in 2nym

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Manganese binding site 3 out of 4 in the Crystal Structure of Protein Phosphatase 2A (PP2A) with C-Terminus Truncated Catalytic Subunit


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 3 of Crystal Structure of Protein Phosphatase 2A (PP2A) with C-Terminus Truncated Catalytic Subunit within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Mn501

b:30.7
occ:1.00
OD1 F:ASN117 2.0 18.0 1.0
ND1 F:HIS241 2.1 38.5 1.0
NE2 F:HIS167 2.2 9.5 1.0
OD2 F:ASP85 2.3 30.5 1.0
CE1 F:HIS167 2.6 13.9 1.0
CE1 F:HIS241 2.7 43.5 1.0
MN F:MN502 2.7 33.5 1.0
CG F:ASN117 2.7 14.8 1.0
ND2 F:ASN117 2.9 4.6 1.0
CG F:ASP85 3.1 29.1 1.0
OD1 F:ASP85 3.3 18.7 1.0
CG F:HIS241 3.4 43.5 1.0
CD2 F:HIS167 3.5 13.8 1.0
OD2 F:ASP57 3.5 35.7 1.0
O F:HIS241 3.7 40.2 1.0
ND1 F:HIS167 3.9 18.7 1.0
CA F:HIS241 3.9 38.7 1.0
NE2 F:HIS241 4.0 35.8 1.0
CB F:HIS241 4.0 42.0 1.0
CB F:ASN117 4.2 20.1 1.0
C F:HIS241 4.2 40.2 1.0
CD2 F:HIS118 4.2 42.0 1.0
CD2 F:HIS241 4.3 41.5 1.0
CG F:HIS167 4.4 17.3 1.0
CB F:ASP85 4.4 34.9 1.0
CG F:ASP57 4.4 38.8 1.0
OD1 F:ASP57 4.6 39.8 1.0
N F:ASN117 4.6 28.1 1.0
NE2 F:HIS59 4.6 39.3 1.0
OXT H:FGA6 4.7 79.9 1.0
NE2 F:HIS118 4.7 47.7 1.0
O3 H:1ZN5 4.9 60.9 1.0
CE1 F:HIS59 5.0 40.3 1.0
CA F:ASN117 5.0 30.3 1.0

Manganese binding site 4 out of 4 in 2nym

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Manganese binding site 4 out of 4 in the Crystal Structure of Protein Phosphatase 2A (PP2A) with C-Terminus Truncated Catalytic Subunit


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 4 of Crystal Structure of Protein Phosphatase 2A (PP2A) with C-Terminus Truncated Catalytic Subunit within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Mn502

b:33.5
occ:1.00
OD2 F:ASP85 2.0 30.5 1.0
OD2 F:ASP57 2.2 35.7 1.0
NE2 F:HIS59 2.3 39.3 1.0
MN F:MN501 2.7 30.7 1.0
CE1 F:HIS59 3.1 40.3 1.0
CG F:ASP85 3.2 29.1 1.0
OXT H:FGA6 3.4 79.9 1.0
CD2 F:HIS59 3.4 39.7 1.0
CG F:ASP57 3.4 38.8 1.0
OH F:TYR265 3.6 20.9 1.0
CB F:ASP85 4.0 34.9 1.0
OD1 F:ASP85 4.1 18.7 1.0
CE1 F:PHE260 4.2 30.6 1.0
O F:HIS241 4.2 40.2 1.0
NE2 F:HIS118 4.2 47.7 1.0
CD2 F:HIS118 4.2 42.0 1.0
OD1 F:ASP57 4.3 39.8 1.0
CE1 F:HIS167 4.3 13.9 1.0
C H:FGA6 4.3 75.6 1.0
ND1 F:HIS59 4.3 37.9 1.0
CB F:ASP57 4.3 35.9 1.0
O H:FGA6 4.4 81.2 1.0
CG F:HIS59 4.5 36.9 1.0
ND1 F:HIS241 4.5 38.5 1.0
OD1 F:ASN117 4.5 18.0 1.0
CZ F:TYR265 4.5 17.9 1.0
ND2 F:ASN117 4.5 4.6 1.0
NE2 F:HIS167 4.6 9.5 1.0
CZ F:PHE260 4.6 33.2 1.0
C F:HIS241 4.8 40.2 1.0
O3 H:1ZN5 4.8 60.9 1.0
CG F:ASN117 5.0 14.8 1.0
CA F:HIS241 5.0 38.7 1.0

Reference:

Y.Xu, Y.Xing, Y.Chen, Y.Chao, Z.Lin, E.Fan, J.W.Yu, S.Strack, P.D.Jeffrey, Y.Shi. Structure of the Protein Phosphatase 2A Holoenzyme. Cell(Cambridge,Mass.) V. 127 1239 2006.
ISSN: ISSN 0092-8674
PubMed: 17174897
DOI: 10.1016/J.CELL.2006.11.033
Page generated: Tue Dec 15 04:03:47 2020

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