Manganese in PDB 2npp: Structure of the Protein Phosphatase 2A Holoenzyme

All present enzymatic activity of Structure of the Protein Phosphatase 2A Holoenzyme:
3.1.3.16;

The structure of Structure of the Protein Phosphatase 2A Holoenzyme, PDB code: 2npp was solved by Y.Xu, Y.Chen, Y.Xing, Y.Chao, Y.Shi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	100.00 / 3.30
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	109.260, 159.050, 269.170, 90.00, 90.00, 90.00
R / Rfree (%)	25.5 / 29.9

The binding sites of Manganese atom in the Structure of the Protein Phosphatase 2A Holoenzyme (pdb code 2npp). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 4 binding sites of Manganese where determined in the Structure of the Protein Phosphatase 2A Holoenzyme, PDB code: 2npp:
Jump to Manganese binding site number: 1; 2; 3; 4;

Manganese binding site 1 out of 4 in the Structure of the Protein Phosphatase 2A Holoenzyme


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Structure of the Protein Phosphatase 2A Holoenzyme within 5.0Å range: probe atom residue distance (Å) B Occ C:Mn501 b:46.3 occ:1.00 OD1 C:ASN117 2.0 48.8 1.0 ND1 C:HIS241 2.1 67.1 1.0 NE2 C:HIS167 2.1 43.4 1.0 OD2 C:ASP85 2.2 59.1 1.0 CE1 C:HIS167 2.5 49.3 1.0 CE1 C:HIS241 2.6 74.6 1.0 MN C:MN502 2.7 65.3 1.0 CG C:ASP85 3.0 56.6 1.0 CG C:ASN117 3.0 46.7 1.0 OD1 C:ASP85 3.2 49.8 1.0 CG C:HIS241 3.3 72.5 1.0 ND2 C:ASN117 3.3 35.8 1.0 CD2 C:HIS167 3.4 48.1 1.0 OD2 C:ASP57 3.6 49.4 1.0 O C:HIS241 3.6 69.4 1.0 ND1 C:HIS167 3.8 51.5 1.0 NE2 C:HIS241 3.8 70.8 1.0 CA C:HIS241 3.9 66.3 1.0 CB C:HIS241 4.0 68.0 1.0 CD2 C:HIS241 4.2 71.3 1.0 C C:HIS241 4.2 67.8 1.0 CD2 C:HIS118 4.2 51.3 1.0 CB C:ASP85 4.3 56.3 1.0 CG C:HIS167 4.3 51.1 1.0 CB C:ASN117 4.3 45.5 1.0 OD1 C:ASP57 4.4 50.0 1.0 CG C:ASP57 4.4 52.4 1.0 NE2 C:HIS59 4.6 57.8 1.0 N C:ASN117 4.7 52.9 1.0 NE2 C:HIS118 4.8 55.5 1.0

Manganese binding site 2 out of 4 in the Structure of the Protein Phosphatase 2A Holoenzyme


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Structure of the Protein Phosphatase 2A Holoenzyme within 5.0Å range: probe atom residue distance (Å) B Occ C:Mn502 b:65.3 occ:1.00 OD2 C:ASP85 2.0 59.1 1.0 OD2 C:ASP57 2.1 49.4 1.0 NE2 C:HIS59 2.3 57.8 1.0 MN C:MN501 2.7 46.3 1.0 CE1 C:HIS59 3.1 55.1 1.0 CG C:ASP85 3.2 56.6 1.0 CG C:ASP57 3.4 52.4 1.0 CD2 C:HIS59 3.4 56.3 1.0 OH C:TYR265 3.9 55.5 1.0 CB C:ASP85 4.0 56.3 1.0 CD2 C:HIS118 4.0 51.3 1.0 O C:HIS241 4.0 69.4 1.0 OD1 C:ASP57 4.1 50.0 1.0 OD1 C:ASP85 4.1 49.8 1.0 NE2 C:HIS118 4.2 55.5 1.0 OD1 C:ASN117 4.2 48.8 1.0 ND1 C:HIS59 4.3 49.7 1.0 CE1 C:HIS167 4.3 49.3 1.0 CB C:ASP57 4.4 50.9 1.0 CE1 C:PHE260 4.4 51.3 1.0 CG C:HIS59 4.5 50.9 1.0 ND1 C:HIS241 4.5 67.1 1.0 NE2 C:HIS167 4.6 43.4 1.0 C C:HIS241 4.6 67.8 1.0 C X:FGA6 4.7 97.2 1.0 CZ C:TYR265 4.7 51.6 1.0 ND2 C:ASN117 4.8 35.8 1.0 CA C:HIS241 4.9 66.3 1.0 O3 X:1ZN5 4.9 89.8 1.0 CE1 C:HIS241 5.0 74.6 1.0 CG C:ASN117 5.0 46.7 1.0

Manganese binding site 3 out of 4 in the Structure of the Protein Phosphatase 2A Holoenzyme


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 3 of Structure of the Protein Phosphatase 2A Holoenzyme within 5.0Å range: probe atom residue distance (Å) B Occ F:Mn501 b:35.5 occ:1.00 OD1 F:ASN117 2.0 46.6 1.0 ND1 F:HIS241 2.1 72.9 1.0 NE2 F:HIS167 2.2 37.8 1.0 CE1 F:HIS241 2.6 78.6 1.0 OD2 F:ASP85 2.6 57.7 1.0 CE1 F:HIS167 2.7 43.2 1.0 MN F:MN502 2.9 56.7 1.0 CG F:ASN117 3.0 42.6 1.0 CG F:ASP85 3.1 54.1 1.0 OD1 F:ASP85 3.1 48.9 1.0 ND2 F:ASN117 3.3 40.4 1.0 CG F:HIS241 3.3 77.8 1.0 CD2 F:HIS167 3.4 42.9 1.0 O F:HIS241 3.6 63.9 1.0 OD2 F:ASP57 3.8 55.3 1.0 NE2 F:HIS241 3.8 75.7 1.0 CA F:HIS241 4.0 63.6 1.0 ND1 F:HIS167 4.0 45.8 1.0 CB F:HIS241 4.1 71.7 1.0 CD2 F:HIS241 4.2 75.9 1.0 CD2 F:HIS118 4.2 50.7 1.0 C F:HIS241 4.2 61.6 1.0 CB F:ASN117 4.3 41.1 1.0 CG F:HIS167 4.4 41.1 1.0 CB F:ASP85 4.4 58.1 1.0 OD1 F:ASP57 4.5 56.9 1.0 CG F:ASP57 4.6 55.5 1.0 N F:ASN117 4.6 46.8 1.0 NE2 F:HIS118 4.8 54.2 1.0 NE2 F:HIS59 4.8 53.8 1.0 CA F:ASN117 5.0 46.3 1.0

Manganese binding site 4 out of 4 in the Structure of the Protein Phosphatase 2A Holoenzyme


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 4 of Structure of the Protein Phosphatase 2A Holoenzyme within 5.0Å range: probe atom residue distance (Å) B Occ F:Mn502 b:56.7 occ:1.00 OD2 F:ASP85 2.0 57.7 1.0 OD2 F:ASP57 2.2 55.3 1.0 NE2 F:HIS59 2.3 53.8 1.0 MN F:MN501 2.9 35.5 1.0 CE1 F:HIS59 3.1 51.9 1.0 CG F:ASP85 3.2 54.1 1.0 CD2 F:HIS59 3.4 51.2 1.0 CG F:ASP57 3.4 55.5 1.0 OH F:TYR265 4.0 50.3 1.0 CD2 F:HIS118 4.1 50.7 1.0 OD1 F:ASP85 4.1 48.9 1.0 CB F:ASP85 4.1 58.1 1.0 O F:HIS241 4.1 63.9 1.0 OD1 F:ASP57 4.1 56.9 1.0 NE2 F:HIS118 4.2 54.2 1.0 ND1 F:HIS59 4.3 45.1 1.0 OD1 F:ASN117 4.4 46.6 1.0 CB F:ASP57 4.4 52.7 1.0 CE1 F:HIS167 4.4 43.2 1.0 CE1 F:PHE260 4.5 64.7 1.0 CG F:HIS59 4.5 44.0 1.0 C Y:FGA6 4.6 93.3 1.0 NE2 F:HIS167 4.6 37.8 1.0 ND1 F:HIS241 4.6 72.9 1.0 CZ F:TYR265 4.7 48.0 1.0 C F:HIS241 4.8 61.6 1.0 O3 Y:1ZN5 4.8 78.5 1.0 CZ F:PHE260 5.0 63.9 1.0

Y.Xu, Y.Xing, Y.Chen, Y.Chao, Z.Lin, E.Fan, J.W.Yu, S.Strack, P.D.Jeffrey, Y.Shi. Structure of the Protein Phosphatase 2A Holoenzyme Cell(Cambridge,Mass.) V. 127 1239 2006.
ISSN: ISSN 0092-8674
PubMed: 17174897
DOI: 10.1016/J.CELL.2006.11.033