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Manganese in PDB 2ie4: Structure of the Protein Phosphatase 2A Core Enzyme Bound to Okadaic Acid

Enzymatic activity of Structure of the Protein Phosphatase 2A Core Enzyme Bound to Okadaic Acid

All present enzymatic activity of Structure of the Protein Phosphatase 2A Core Enzyme Bound to Okadaic Acid:
3.1.3.16;

Protein crystallography data

The structure of Structure of the Protein Phosphatase 2A Core Enzyme Bound to Okadaic Acid, PDB code: 2ie4 was solved by Y.Xing, Y.Xu, Y.Chen, P.D.Jeffrey, Y.Chao, Y.Shi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 2.60
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 92.540, 194.850, 201.350, 90.00, 90.00, 90.00
R / Rfree (%) 27 / 23

Manganese Binding Sites:

The binding sites of Manganese atom in the Structure of the Protein Phosphatase 2A Core Enzyme Bound to Okadaic Acid (pdb code 2ie4). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the Structure of the Protein Phosphatase 2A Core Enzyme Bound to Okadaic Acid, PDB code: 2ie4:
Jump to Manganese binding site number: 1; 2;

Manganese binding site 1 out of 2 in 2ie4

Go back to Manganese Binding Sites List in 2ie4
Manganese binding site 1 out of 2 in the Structure of the Protein Phosphatase 2A Core Enzyme Bound to Okadaic Acid


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Structure of the Protein Phosphatase 2A Core Enzyme Bound to Okadaic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Mn501

b:27.6
occ:1.00
OD1 C:ASN117 2.0 30.6 1.0
ND1 C:HIS241 2.1 38.3 1.0
NE2 C:HIS167 2.1 37.6 1.0
OD2 C:ASP85 2.7 24.0 1.0
CE1 C:HIS241 2.9 38.7 1.0
CG C:ASN117 2.9 34.2 1.0
CE1 C:HIS167 3.0 30.4 1.0
MN C:MN502 3.0 39.5 1.0
CG C:HIS241 3.2 29.6 1.0
CD2 C:HIS167 3.2 34.1 1.0
ND2 C:ASN117 3.2 27.6 1.0
CG C:ASP85 3.3 29.9 1.0
OD1 C:ASP85 3.4 28.5 1.0
O C:HOH503 3.4 22.6 1.0
CA C:HIS241 3.6 28.1 1.0
CB C:HIS241 3.7 29.3 1.0
OD2 C:ASP57 3.9 21.9 1.0
O C:HIS241 3.9 26.6 1.0
NE2 C:HIS241 4.1 27.4 1.0
ND1 C:HIS167 4.1 35.2 1.0
C C:HIS241 4.2 28.1 1.0
CD2 C:HIS241 4.2 27.8 1.0
CD2 C:HIS118 4.3 27.7 1.0
CB C:ASN117 4.3 28.2 1.0
CG C:HIS167 4.3 38.7 1.0
N C:ASN117 4.6 29.8 1.0
CB C:ASP85 4.6 31.6 1.0
N C:HIS241 4.6 25.4 1.0
CG C:ASP57 4.8 30.6 1.0
NE2 C:HIS118 4.9 30.2 1.0
NE2 C:HIS59 4.9 29.3 1.0
O C:LEU199 5.0 42.6 1.0
NH1 C:ARG214 5.0 26.3 1.0

Manganese binding site 2 out of 2 in 2ie4

Go back to Manganese Binding Sites List in 2ie4
Manganese binding site 2 out of 2 in the Structure of the Protein Phosphatase 2A Core Enzyme Bound to Okadaic Acid


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Structure of the Protein Phosphatase 2A Core Enzyme Bound to Okadaic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Mn502

b:39.5
occ:1.00
OD2 C:ASP85 2.0 24.0 1.0
OD2 C:ASP57 2.2 21.9 1.0
NE2 C:HIS59 2.3 29.3 1.0
MN C:MN501 3.0 27.6 1.0
CE1 C:HIS59 3.2 32.7 1.0
CG C:ASP85 3.2 29.9 1.0
CD2 C:HIS59 3.4 29.4 1.0
CG C:ASP57 3.4 30.6 1.0
O C:HOH503 3.5 22.6 1.0
O C:HIS241 4.0 26.6 1.0
CB C:ASP85 4.0 31.6 1.0
OD1 C:ASP85 4.1 28.5 1.0
CD2 C:HIS118 4.2 27.7 1.0
OH C:TYR265 4.2 34.7 1.0
CB C:ASP57 4.2 35.5 1.0
OD1 C:ASP57 4.3 37.2 1.0
ND1 C:HIS59 4.3 32.4 1.0
CE1 C:HIS167 4.4 30.4 1.0
NE2 C:HIS118 4.4 30.2 1.0
NE2 C:HIS167 4.4 37.6 1.0
OD1 C:ASN117 4.5 30.6 1.0
CG C:HIS59 4.5 39.5 1.0
CA C:HIS241 4.5 28.1 1.0
CE1 C:PHE260 4.6 32.0 1.0
C C:HIS241 4.6 28.1 1.0
ND1 C:HIS241 4.7 38.3 1.0
CZ C:TYR265 4.8 28.8 1.0

Reference:

Y.Xing, Y.Xu, Y.Chen, P.D.Jeffrey, Y.Chao, Z.Lin, Z.Li, S.Strack, J.B.Stock, Y.Shi. Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins Cell(Cambridge,Mass.) V. 127 341 2006.
ISSN: ISSN 0092-8674
PubMed: 17055435
DOI: 10.1016/J.CELL.2006.09.025
Page generated: Tue Dec 15 04:02:51 2020

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