Manganese in PDB 2ick: Human Isopentenyl Diphophate Isomerase Complexed with Substrate Analog

All present enzymatic activity of Human Isopentenyl Diphophate Isomerase Complexed with Substrate Analog:
5.3.3.2;

The structure of Human Isopentenyl Diphophate Isomerase Complexed with Substrate Analog, PDB code: 2ick was solved by W.Zheng, M.Bartlam, Z.Rao, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 1.93
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	40.812, 47.396, 116.817, 90.00, 90.00, 90.00
R / Rfree (%)	20.5 / 25.5

The binding sites of Manganese atom in the Human Isopentenyl Diphophate Isomerase Complexed with Substrate Analog (pdb code 2ick). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Human Isopentenyl Diphophate Isomerase Complexed with Substrate Analog, PDB code: 2ick:

Manganese binding site 1 out of 1 in the Human Isopentenyl Diphophate Isomerase Complexed with Substrate Analog


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Human Isopentenyl Diphophate Isomerase Complexed with Substrate Analog within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn229 b:28.4 occ:1.00 OE2 A:GLU149 2.1 27.6 1.0 NE2 A:HIS89 2.2 30.0 1.0 OE1 A:GLU147 2.2 24.2 1.0 NE2 A:HIS41 2.3 25.0 1.0 NE2 A:HIS52 2.3 24.4 1.0 OE2 A:GLU147 2.4 29.1 1.0 CD A:GLU147 2.6 26.3 1.0 CD2 A:HIS89 3.0 28.7 1.0 CD A:GLU149 3.0 31.4 1.0 CE1 A:HIS41 3.0 28.7 1.0 CE1 A:HIS52 3.1 23.5 1.0 CE1 A:HIS89 3.2 35.5 1.0 CD2 A:HIS41 3.3 28.5 1.0 CD2 A:HIS52 3.4 23.8 1.0 CG A:GLU149 3.5 28.1 1.0 C2 A:DMA301 3.6 71.3 1.0 C3 A:DMA301 4.0 71.8 1.0 C1 A:DMA301 4.1 71.8 1.0 OE1 A:GLU149 4.1 25.6 1.0 CG A:GLU147 4.1 26.1 1.0 CG A:HIS89 4.2 32.1 1.0 ND1 A:HIS41 4.2 27.8 1.0 ND1 A:HIS89 4.3 35.4 1.0 ND1 A:HIS52 4.3 24.6 1.0 C4 A:DMA301 4.3 71.8 1.0 CG A:HIS41 4.4 23.3 1.0 CG A:HIS52 4.4 24.0 1.0 CB A:ALA54 4.8 24.4 1.0 C5 A:DMA301 4.8 70.9 1.0 CB A:GLU147 4.9 25.7 1.0 CB A:GLU149 4.9 27.5 1.0 O A:HOH448 5.0 35.5 1.0

W.Zheng, F.Sun, M.Bartlam, X.Li, R.Li, Z.Rao. The Crystal Structure of Human Isopentenyl Diphosphate Isomerase at 1.7 A Resolution Reveals Its Catalytic Mechanism in Isoprenoid Biosynthesis J.Mol.Biol. V. 366 1447 2007.
ISSN: ISSN 0022-2836
PubMed: 17250851
DOI: 10.1016/J.JMB.2006.12.055