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Manganese in PDB 2iae: Crystal Structure of A Protein Phosphatase 2A (PP2A) Holoenzyme.

Enzymatic activity of Crystal Structure of A Protein Phosphatase 2A (PP2A) Holoenzyme.

All present enzymatic activity of Crystal Structure of A Protein Phosphatase 2A (PP2A) Holoenzyme.:
3.1.3.16;

Protein crystallography data

The structure of Crystal Structure of A Protein Phosphatase 2A (PP2A) Holoenzyme., PDB code: 2iae was solved by U.S.Cho, W.Xu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 3.50
Space group P 21 3
Cell size a, b, c (Å), α, β, γ (°) 265.301, 265.301, 265.301, 90.00, 90.00, 90.00
R / Rfree (%) 25.7 / 31.6

Manganese Binding Sites:

The binding sites of Manganese atom in the Crystal Structure of A Protein Phosphatase 2A (PP2A) Holoenzyme. (pdb code 2iae). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 4 binding sites of Manganese where determined in the Crystal Structure of A Protein Phosphatase 2A (PP2A) Holoenzyme., PDB code: 2iae:
Jump to Manganese binding site number: 1; 2; 3; 4;

Manganese binding site 1 out of 4 in 2iae

Go back to Manganese Binding Sites List in 2iae
Manganese binding site 1 out of 4 in the Crystal Structure of A Protein Phosphatase 2A (PP2A) Holoenzyme.


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Crystal Structure of A Protein Phosphatase 2A (PP2A) Holoenzyme. within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Mn310

b:0.6
occ:1.00
OD1 C:ASP57 2.3 91.5 1.0
OD1 C:ASP85 2.3 87.7 1.0
MN C:MN311 2.6 63.2 1.0
NE2 C:HIS59 2.8 91.2 1.0
O C:HIS241 3.4 0.7 1.0
CG C:ASP57 3.4 91.2 1.0
CA C:HIS241 3.5 0.1 1.0
CG C:ASP85 3.5 88.1 1.0
ND1 C:HIS241 3.6 0.6 1.0
CE1 C:HIS59 3.6 91.4 1.0
C C:HIS241 3.8 0.5 1.0
ND2 C:ASN117 3.8 89.7 1.0
CD2 C:HIS59 4.0 91.8 1.0
OD2 C:ASP57 4.0 90.5 1.0
O M:FGA6 4.1 91.2 1.0
CD2 C:HIS118 4.2 90.3 1.0
CB C:ASP85 4.2 89.1 1.0
CB C:HIS241 4.2 0.0 1.0
CG C:HIS241 4.3 0.2 1.0
NE2 C:HIS167 4.3 90.2 1.0
OD1 C:ASN117 4.3 88.8 1.0
N C:HIS241 4.4 0.1 1.0
NE2 C:HIS118 4.4 90.2 1.0
OD2 C:ASP85 4.5 86.4 1.0
CE1 C:HIS241 4.5 0.2 1.0
CG C:ASN117 4.5 89.7 1.0
CE1 C:HIS167 4.6 91.0 1.0
CB C:ASP57 4.6 91.3 1.0
OH C:TYR267 4.6 0.5 1.0
CE2 C:PHE260 4.7 0.3 1.0
ND1 C:HIS59 4.8 92.1 1.0
C M:FGA6 4.9 90.2 1.0
N C:GLN242 4.9 0.7 1.0

Manganese binding site 2 out of 4 in 2iae

Go back to Manganese Binding Sites List in 2iae
Manganese binding site 2 out of 4 in the Crystal Structure of A Protein Phosphatase 2A (PP2A) Holoenzyme.


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Crystal Structure of A Protein Phosphatase 2A (PP2A) Holoenzyme. within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Mn311

b:63.2
occ:1.00
ND2 C:ASN117 1.7 89.7 1.0
ND1 C:HIS241 2.1 0.6 1.0
NE2 C:HIS167 2.1 90.2 1.0
OD1 C:ASP85 2.5 87.7 1.0
MN C:MN310 2.6 0.6 1.0
CG C:ASN117 2.8 89.7 1.0
CG C:HIS241 2.9 0.2 1.0
CE1 C:HIS167 2.9 91.0 1.0
CB C:HIS241 3.0 0.0 1.0
CD2 C:HIS167 3.1 90.8 1.0
CE1 C:HIS241 3.1 0.2 1.0
CG C:ASP85 3.2 88.1 1.0
OD1 C:ASN117 3.2 88.8 1.0
CA C:HIS241 3.3 0.1 1.0
OD2 C:ASP85 3.4 86.4 1.0
OD1 C:ASP57 3.8 91.5 1.0
CB C:ASN117 4.0 89.9 1.0
O C:HIS241 4.0 0.7 1.0
ND1 C:HIS167 4.1 91.0 1.0
CD2 C:HIS241 4.1 0.4 1.0
N C:ASN117 4.1 89.8 1.0
NE2 C:HIS241 4.2 0.2 1.0
C C:HIS241 4.2 0.5 1.0
CG C:HIS167 4.2 90.8 1.0
OD2 C:ASP57 4.2 90.5 1.0
N C:HIS241 4.3 0.1 1.0
CB C:ASP85 4.3 89.1 1.0
CG C:ASP57 4.4 91.2 1.0
CD2 C:HIS118 4.4 90.3 1.0
CA C:ASN117 4.6 90.0 1.0
O C:LEU199 4.8 87.2 1.0
NE2 C:HIS59 4.9 91.2 1.0
N C:HIS118 4.9 90.8 1.0

Manganese binding site 3 out of 4 in 2iae

Go back to Manganese Binding Sites List in 2iae
Manganese binding site 3 out of 4 in the Crystal Structure of A Protein Phosphatase 2A (PP2A) Holoenzyme.


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 3 of Crystal Structure of A Protein Phosphatase 2A (PP2A) Holoenzyme. within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Mn310

b:86.2
occ:1.00
OD1 F:ASP85 2.1 0.4 1.0
OD2 F:ASP57 2.3 0.2 1.0
NE2 F:HIS59 2.3 0.4 1.0
MN F:MN311 3.0 33.6 1.0
CE1 F:HIS59 3.0 0.5 1.0
CG F:ASP85 3.3 0.8 1.0
CG F:ASP57 3.4 0.9 1.0
CD2 F:HIS59 3.4 0.5 1.0
OH F:TYR267 3.5 0.5 1.0
O F:HIS241 3.8 0.1 1.0
CE1 F:HIS118 3.9 1.0 1.0
CB F:ASP85 4.0 0.4 1.0
ND1 F:HIS118 4.0 0.9 1.0
ND2 F:ASN117 4.2 1.0 1.0
CB F:ASP57 4.2 0.2 1.0
ND1 F:HIS59 4.2 0.2 1.0
OD2 F:ASP85 4.2 0.8 1.0
OD1 F:ASP57 4.3 0.7 1.0
O N:FGA6 4.4 83.5 1.0
C F:HIS241 4.4 0.9 1.0
CG F:HIS59 4.4 0.9 1.0
NE2 F:HIS167 4.4 0.6 1.0
CA F:HIS241 4.5 0.1 1.0
CE1 F:HIS167 4.6 0.1 1.0
CZ F:TYR267 4.6 1.0 1.0
OD1 F:ASN117 4.6 0.7 1.0
CE2 F:PHE260 4.6 0.2 1.0
NE2 F:HIS118 4.7 0.0 1.0
CE2 F:TYR267 4.9 0.3 1.0
CG F:ASN117 4.9 0.8 1.0
CZ F:PHE260 4.9 0.0 1.0

Manganese binding site 4 out of 4 in 2iae

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Manganese binding site 4 out of 4 in the Crystal Structure of A Protein Phosphatase 2A (PP2A) Holoenzyme.


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 4 of Crystal Structure of A Protein Phosphatase 2A (PP2A) Holoenzyme. within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Mn311

b:33.6
occ:1.00
ND2 F:ASN117 2.0 1.0 1.0
NE2 F:HIS167 2.1 0.6 1.0
OD1 F:ASP85 2.6 0.4 1.0
CG F:ASN117 2.7 0.8 1.0
CD2 F:HIS241 2.8 0.6 1.0
CG F:HIS241 2.9 0.2 1.0
OD1 F:ASN117 3.0 0.7 1.0
MN F:MN310 3.0 86.2 1.0
CA F:HIS241 3.1 0.1 1.0
CE1 F:HIS167 3.1 0.1 1.0
CD2 F:HIS167 3.2 0.5 1.0
O F:HIS241 3.3 0.1 1.0
CG F:ASP85 3.3 0.8 1.0
CB F:HIS241 3.3 0.4 1.0
NE2 F:HIS241 3.4 0.1 1.0
ND1 F:HIS241 3.5 0.9 1.0
OD2 F:ASP85 3.6 0.8 1.0
C F:HIS241 3.6 0.9 1.0
OD2 F:ASP57 3.6 0.2 1.0
CE1 F:HIS241 3.8 0.3 1.0
CB F:ASN117 4.0 0.8 1.0
ND1 F:HIS167 4.2 0.4 1.0
N F:HIS241 4.2 0.0 1.0
CG F:HIS167 4.3 0.1 1.0
ND1 F:HIS118 4.4 0.9 1.0
CG F:ASP57 4.4 0.9 1.0
CB F:ASP85 4.5 0.4 1.0
OD1 F:ASP57 4.5 0.7 1.0
N F:ASN117 4.6 0.6 1.0
CE1 F:HIS118 4.8 1.0 1.0
NE2 F:HIS59 4.9 0.4 1.0
CA F:ASN117 4.9 1.0 1.0
N F:GLN242 4.9 0.7 1.0

Reference:

U.S.Cho, W.Xu. Crystal Structure of A Protein Phosphatase 2A Heterotrimeric Holoenzyme. Nature V. 445 53 2007.
ISSN: ISSN 0028-0836
PubMed: 17086192
DOI: 10.1038/NATURE05351
Page generated: Tue Dec 15 04:02:43 2020

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