Manganese in PDB 2ga2: H-METAP2 Complexed with A193400

All present enzymatic activity of H-METAP2 Complexed with A193400:
3.4.11.18;

The structure of H-METAP2 Complexed with A193400, PDB code: 2ga2 was solved by C.Park, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	15.79 / 1.95
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	89.731, 98.793, 101.213, 90.00, 90.00, 90.00
R / Rfree (%)	n/a / n/a

The structure of H-METAP2 Complexed with A193400 also contains other interesting chemical elements:

Bromine	(Br)	1 atom
Chlorine	(Cl)	1 atom

The binding sites of Manganese atom in the H-METAP2 Complexed with A193400 (pdb code 2ga2). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the H-METAP2 Complexed with A193400, PDB code: 2ga2:
Jump to Manganese binding site number: 1; 2;

Manganese binding site 1 out of 2 in the H-METAP2 Complexed with A193400


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of H-METAP2 Complexed with A193400 within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn480 b:17.4 occ:1.00 OD2 A:ASP262 2.1 16.6 1.0 OD2 A:ASP251 2.2 14.2 1.0 OE2 A:GLU459 2.2 13.8 1.0 O A:HOH793 2.3 52.4 1.0 OD1 A:ASP251 2.3 13.5 1.0 O A:HOH645 2.4 31.1 1.0 CG A:ASP251 2.5 14.0 1.0 CG A:ASP262 3.0 16.5 1.0 CD A:GLU459 3.1 14.8 1.0 OD1 A:ASP262 3.3 16.6 1.0 OE1 A:GLU459 3.3 14.1 1.0 MN A:MN481 3.3 19.3 1.0 CZ A:PHE219 4.0 15.0 1.0 CB A:ASP251 4.0 14.3 1.0 OE2 A:GLU364 4.1 18.1 1.0 NE2 A:GLN457 4.2 15.4 1.0 CE2 A:PHE219 4.2 15.1 1.0 O20 A:A19482 4.3 44.1 1.0 O21 A:A19482 4.3 44.1 1.0 CB A:ASP262 4.4 16.6 1.0 CG A:GLU459 4.5 14.5 1.0 CB A:ALA264 4.6 16.1 1.0 N A:CYS263 4.6 16.5 1.0 CD A:GLU364 4.7 18.5 1.0 C A:ASP262 4.7 16.5 1.0 C19 A:A19482 4.7 44.4 1.0 OE1 A:GLU364 4.7 18.7 1.0 CA A:ASP262 4.7 16.6 1.0 O A:HOH650 4.8 43.8 1.0 CE1 A:PHE219 4.9 15.0 1.0 CA A:ASP251 4.9 14.6 1.0 CB A:GLU459 4.9 14.6 1.0 O A:CYS263 4.9 16.2 1.0 C A:CYS263 5.0 16.4 1.0

Manganese binding site 2 out of 2 in the H-METAP2 Complexed with A193400


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of H-METAP2 Complexed with A193400 within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn481 b:19.3 occ:1.00 OE1 A:GLU459 2.2 14.1 1.0 OD1 A:ASP262 2.2 16.6 1.0 OE1 A:GLU364 2.3 18.7 1.0 NE2 A:HIS331 2.4 18.4 1.0 O A:HOH793 2.4 52.4 1.0 O21 A:A19482 2.4 44.1 1.0 CD A:GLU364 3.0 18.5 1.0 CG A:ASP262 3.1 16.5 1.0 CD A:GLU459 3.2 14.8 1.0 CD2 A:HIS331 3.3 18.4 1.0 MN A:MN480 3.3 17.4 1.0 CE1 A:HIS331 3.4 18.5 1.0 C19 A:A19482 3.4 44.4 1.0 OE2 A:GLU364 3.4 18.1 1.0 OD2 A:ASP262 3.5 16.6 1.0 OE2 A:GLU459 3.6 13.8 1.0 O20 A:A19482 3.7 44.1 1.0 CB A:ALA362 3.9 18.4 1.0 O A:HOH645 4.1 31.1 1.0 CG A:GLU364 4.1 18.1 1.0 CB A:ASP262 4.3 16.6 1.0 C6 A:A19482 4.4 45.9 1.0 CG A:HIS331 4.5 18.5 1.0 ND1 A:HIS331 4.5 18.5 1.0 CG A:GLU459 4.5 14.5 1.0 C7 A:A19482 4.7 46.0 1.0 C17 A:A19482 4.8 44.7 1.0 CD1 A:ILE338 4.9 24.2 1.0 OD2 A:ASP251 5.0 14.2 1.0

M.Kawai, N.Y.Bamaung, S.D.Fidanze, S.A.Erickson, J.S.Tedrow, W.J.Sanders, A.Vasudevan, C.Park, C.Hutchins, K.M.Comess, D.Kalvin, J.Wang, Q.Zhang, P.Lou, L.Tucker-Garcia, J.Bouska, R.L.Bell, R.Lesniewski, J.Henkin, G.S.Sheppard. Development of Sulfonamide Compounds As Potent Methionine Aminopeptidase Type II Inhibitors with Antiproliferative Properties. Bioorg.Med.Chem.Lett. V. 16 3574 2006.
ISSN: ISSN 0960-894X
PubMed: 16632353
DOI: 10.1016/J.BMCL.2006.03.085