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Manganese in PDB 2fyb: Crystal Structure of the Catalytic Domain of the Human BETA1,4-Galactosyltransferase Mutant M339H in Complex with Mn and Udp-Galactose in Open Conformation

Enzymatic activity of Crystal Structure of the Catalytic Domain of the Human BETA1,4-Galactosyltransferase Mutant M339H in Complex with Mn and Udp-Galactose in Open Conformation

All present enzymatic activity of Crystal Structure of the Catalytic Domain of the Human BETA1,4-Galactosyltransferase Mutant M339H in Complex with Mn and Udp-Galactose in Open Conformation:
2.4.1.90;

Protein crystallography data

The structure of Crystal Structure of the Catalytic Domain of the Human BETA1,4-Galactosyltransferase Mutant M339H in Complex with Mn and Udp-Galactose in Open Conformation, PDB code: 2fyb was solved by B.Ramakrishnan, V.Ramasamy, P.K.Qasba, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.79 / 1.90
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 70.560, 137.730, 66.430, 90.00, 90.00, 90.00
R / Rfree (%) 17.8 / 21.6

Manganese Binding Sites:

The binding sites of Manganese atom in the Crystal Structure of the Catalytic Domain of the Human BETA1,4-Galactosyltransferase Mutant M339H in Complex with Mn and Udp-Galactose in Open Conformation (pdb code 2fyb). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Crystal Structure of the Catalytic Domain of the Human BETA1,4-Galactosyltransferase Mutant M339H in Complex with Mn and Udp-Galactose in Open Conformation, PDB code: 2fyb:

Manganese binding site 1 out of 1 in 2fyb

Go back to Manganese Binding Sites List in 2fyb
Manganese binding site 1 out of 1 in the Crystal Structure of the Catalytic Domain of the Human BETA1,4-Galactosyltransferase Mutant M339H in Complex with Mn and Udp-Galactose in Open Conformation


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Crystal Structure of the Catalytic Domain of the Human BETA1,4-Galactosyltransferase Mutant M339H in Complex with Mn and Udp-Galactose in Open Conformation within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn402

b:26.0
occ:1.00
O A:HOH561 2.0 27.8 1.0
NE2 A:HIS343 2.1 53.8 1.0
OD2 A:ASP250 2.2 22.2 1.0
O1A A:UDP403 2.2 28.9 1.0
NE2 A:HIS340 2.3 25.6 1.0
O A:HOH699 2.4 32.4 1.0
CE1 A:HIS343 2.9 55.5 1.0
CG A:ASP250 3.1 23.3 1.0
CD2 A:HIS343 3.2 54.2 1.0
CD2 A:HIS340 3.3 24.6 1.0
CE1 A:HIS340 3.3 26.0 1.0
PA A:UDP403 3.5 31.4 1.0
OD1 A:ASP250 3.6 24.9 1.0
O3A A:UDP403 3.8 34.4 1.0
O A:HOH570 3.8 31.5 1.0
ND1 A:HIS343 4.1 55.1 1.0
NH2 A:ARG187 4.2 27.7 1.0
O3' A:UDP403 4.2 22.5 1.0
NZ A:LYS275 4.2 42.1 1.0
CB A:ASP250 4.2 22.2 1.0
CG A:HIS343 4.3 55.1 1.0
NH1 A:ARG187 4.3 25.1 1.0
O2A A:UDP403 4.4 29.9 1.0
ND1 A:HIS340 4.4 25.4 1.0
CG A:HIS340 4.4 25.2 1.0
O5' A:UDP403 4.5 28.3 1.0
C5' A:UDP403 4.7 25.6 1.0
CZ A:ARG187 4.7 25.8 1.0
O A:ILE341 4.8 34.4 1.0
C3' A:UDP403 4.8 22.2 1.0
O A:HOH619 4.9 37.6 1.0

Reference:

B.Ramakrishnan, V.Ramasamy, P.K.Qasba. Structural Snapshots of Beta-1,4-Galactosyltransferase-I Along the Kinetic Pathway. J.Mol.Biol. V. 357 1619 2006.
ISSN: ISSN 0022-2836
PubMed: 16497331
DOI: 10.1016/J.JMB.2006.01.088
Page generated: Tue Dec 15 04:01:52 2020

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