Manganese in PDB 2ffv: Human Ppgalnact-2 Complexed with Manganese and Udp

All present enzymatic activity of Human Ppgalnact-2 Complexed with Manganese and Udp:
2.4.1.41;

The structure of Human Ppgalnact-2 Complexed with Manganese and Udp, PDB code: 2ffv was solved by T.A.Fritz, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.10 / 2.75
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	153.228, 153.228, 110.144, 90.00, 90.00, 90.00
R / Rfree (%)	22.5 / 28.6

The binding sites of Manganese atom in the Human Ppgalnact-2 Complexed with Manganese and Udp (pdb code 2ffv). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the Human Ppgalnact-2 Complexed with Manganese and Udp, PDB code: 2ffv:
Jump to Manganese binding site number: 1; 2;

Manganese binding site 1 out of 2 in the Human Ppgalnact-2 Complexed with Manganese and Udp


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Human Ppgalnact-2 Complexed with Manganese and Udp within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn5600 b:23.9 occ:1.00 O2A A:UDP5601 2.2 45.6 1.0 NE2 A:HIS226 2.2 25.4 1.0 NE2 A:HIS359 2.3 23.6 1.0 OD2 A:ASP224 2.3 39.2 1.0 O1B A:UDP5601 2.5 44.5 1.0 CE1 A:HIS226 3.0 24.2 1.0 O3B A:UDP5601 3.1 45.7 1.0 PB A:UDP5601 3.1 43.5 1.0 CG A:ASP224 3.1 38.8 1.0 CE1 A:HIS359 3.2 23.8 1.0 CD2 A:HIS359 3.3 23.6 1.0 CD2 A:HIS226 3.4 25.2 1.0 PA A:UDP5601 3.4 44.3 1.0 O3A A:UDP5601 3.6 45.6 1.0 CB A:ASP224 3.6 36.4 1.0 OD1 A:ASP224 4.0 39.6 1.0 O1A A:UDP5601 4.1 45.5 1.0 ND1 A:HIS226 4.1 24.5 1.0 ND1 A:HIS359 4.4 24.1 1.0 CG A:HIS226 4.4 25.8 1.0 CG A:HIS359 4.4 23.9 1.0 O2B A:UDP5601 4.6 44.8 1.0 O5' A:UDP5601 4.6 45.9 1.0 O A:VAL360 4.9 21.7 1.0 C5' A:UDP5601 5.0 49.1 1.0

Manganese binding site 2 out of 2 in the Human Ppgalnact-2 Complexed with Manganese and Udp


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Human Ppgalnact-2 Complexed with Manganese and Udp within 5.0Å range: probe atom residue distance (Å) B Occ B:Mn9600 b:39.6 occ:1.00 OD2 B:ASP224 2.1 47.7 1.0 O1B B:UDP9601 2.1 59.3 1.0 NE2 B:HIS226 2.1 38.9 1.0 O2A B:UDP9601 2.3 60.8 1.0 NE2 B:HIS359 2.3 24.4 1.0 CE1 B:HIS226 3.0 38.8 1.0 PB B:UDP9601 3.1 58.7 1.0 CG B:ASP224 3.1 45.1 1.0 CD2 B:HIS226 3.2 38.4 1.0 CE1 B:HIS359 3.3 22.6 1.0 CD2 B:HIS359 3.3 24.5 1.0 O3B B:UDP9601 3.4 59.2 1.0 PA B:UDP9601 3.6 61.7 1.0 CB B:ASP224 3.6 43.6 1.0 O3A B:UDP9601 3.7 60.8 1.0 ND1 B:HIS226 4.1 37.8 1.0 OD1 B:ASP224 4.2 45.2 1.0 CG B:HIS226 4.3 38.6 1.0 ND1 B:HIS359 4.4 22.8 1.0 CG B:HIS359 4.4 22.8 1.0 O5' B:UDP9601 4.5 64.1 1.0 O2B B:UDP9601 4.5 59.6 1.0 O1A B:UDP9601 4.6 62.7 1.0 O B:VAL360 4.6 40.7 1.0

T.A.Fritz, J.Raman, L.A.Tabak. Dynamic Association Between the Catalytic and Lectin Domains of Human Udp-Galnac:Polypeptide {Alpha}-N-Acetylgalactosaminyltransferase-2 J.Biol.Chem. V. 281 8613 2006.
ISSN: ISSN 0021-9258
PubMed: 16434399
DOI: 10.1074/JBC.M513590200