Atomistry » Manganese » PDB 2ayl-2ce4 » 2bb7
Atomistry »
  Manganese »
    PDB 2ayl-2ce4 »
      2bb7 »

Manganese in PDB 2bb7: Mn Form of E. Coli Methionine Aminopeptidase in Complex with A Quinolinyl Sulfonamide Inhibitor

Enzymatic activity of Mn Form of E. Coli Methionine Aminopeptidase in Complex with A Quinolinyl Sulfonamide Inhibitor

All present enzymatic activity of Mn Form of E. Coli Methionine Aminopeptidase in Complex with A Quinolinyl Sulfonamide Inhibitor:
3.4.11.18;

Protein crystallography data

The structure of Mn Form of E. Coli Methionine Aminopeptidase in Complex with A Quinolinyl Sulfonamide Inhibitor, PDB code: 2bb7 was solved by Q.Z.Ye, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 17.62 / 1.70
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 38.039, 60.416, 50.521, 90.00, 104.40, 90.00
R / Rfree (%) 18.7 / 23.3

Other elements in 2bb7:

The structure of Mn Form of E. Coli Methionine Aminopeptidase in Complex with A Quinolinyl Sulfonamide Inhibitor also contains other interesting chemical elements:

Sodium (Na) 1 atom

Manganese Binding Sites:

The binding sites of Manganese atom in the Mn Form of E. Coli Methionine Aminopeptidase in Complex with A Quinolinyl Sulfonamide Inhibitor (pdb code 2bb7). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 3 binding sites of Manganese where determined in the Mn Form of E. Coli Methionine Aminopeptidase in Complex with A Quinolinyl Sulfonamide Inhibitor, PDB code: 2bb7:
Jump to Manganese binding site number: 1; 2; 3;

Manganese binding site 1 out of 3 in 2bb7

Go back to Manganese Binding Sites List in 2bb7
Manganese binding site 1 out of 3 in the Mn Form of E. Coli Methionine Aminopeptidase in Complex with A Quinolinyl Sulfonamide Inhibitor


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Mn Form of E. Coli Methionine Aminopeptidase in Complex with A Quinolinyl Sulfonamide Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn301

b:14.4
occ:1.00
 O A:HOH319 2.0 13.3 1.0
OD1 A:ASP108 2.1 12.9 1.0
OE1 A:GLU235 2.2 13.7 1.0
OD1 A:ASP97 2.2 13.0 1.0
O A:HOH313 2.4 12.9 1.0
OD2 A:ASP97 2.5 12.1 1.0
CG A:ASP97 2.7 14.0 1.0
CG A:ASP108 3.0 11.1 1.0
CD A:GLU235 3.1 11.0 1.0
MN A:MN302 3.3 15.9 1.0
OD2 A:ASP108 3.3 13.1 1.0
OE2 A:GLU235 3.4 13.3 1.0
O A:HOH309 3.7 19.0 1.0
O A:HOH307 3.8 15.1 1.0
OG1 A:THR99 3.9 16.1 1.0
CB A:ASP97 4.2 12.9 1.0
O A:HOH341 4.3 17.8 1.0
O A:VAL98 4.4 12.8 1.0
O A:HOH337 4.4 16.6 1.0
CG A:GLU235 4.5 11.9 1.0
CB A:ASP108 4.5 14.4 1.0
OE1 A:GLU204 4.5 17.2 1.0
N A:THR109 4.5 13.3 1.0
O A:THR109 4.7 12.1 1.0
OE2 A:GLU204 4.7 14.4 1.0
C A:ASP108 4.7 13.6 1.0
O A:HOH327 4.8 15.4 1.0
C A:THR109 4.8 11.9 1.0
CD A:GLU204 4.9 14.0 1.0
CA A:ASP108 4.9 13.8 1.0
CB A:GLU235 4.9 12.4 1.0
N A:VAL98 4.9 13.7 1.0
O A:HOH360 4.9 18.5 1.0
CA A:ASP97 4.9 12.7 1.0

Manganese binding site 2 out of 3 in 2bb7

Go back to Manganese Binding Sites List in 2bb7
Manganese binding site 2 out of 3 in the Mn Form of E. Coli Methionine Aminopeptidase in Complex with A Quinolinyl Sulfonamide Inhibitor


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Mn Form of E. Coli Methionine Aminopeptidase in Complex with A Quinolinyl Sulfonamide Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn302

b:15.9
occ:1.00
 O A:HOH319 2.0 13.3 1.0
OE2 A:GLU235 2.2 13.3 1.0
OD2 A:ASP108 2.2 13.1 1.0
OE2 A:GLU204 2.2 14.4 1.0
NE2 A:HIS171 2.3 15.2 1.0
CD A:GLU235 3.0 11.0 1.0
CG A:ASP108 3.1 11.1 1.0
CD A:GLU204 3.1 14.0 1.0
CD2 A:HIS171 3.2 15.5 1.0
OE1 A:GLU235 3.2 13.7 1.0
MN A:MN301 3.3 14.4 1.0
CE1 A:HIS171 3.3 17.7 1.0
O A:HOH521 3.3 27.8 1.0
OE1 A:GLU204 3.3 17.2 1.0
OD1 A:ASP108 3.4 12.9 1.0
OG1 A:THR202 3.6 15.3 1.0
O A:HOH309 3.8 19.0 1.0
CG2 A:THR202 3.9 18.1 1.0
CB A:THR202 4.1 16.1 1.0
CB A:ASP108 4.3 14.4 1.0
ND1 A:HIS171 4.3 14.8 1.0
CG A:HIS171 4.4 15.3 1.0
CG A:GLU235 4.4 11.9 1.0
CG A:GLU204 4.4 13.8 1.0
O A:HOH313 4.5 12.9 1.0
NE2 A:HIS178 4.7 18.0 1.0
CD2 A:HIS178 4.8 20.3 1.0
CE1 A:PHE177 4.9 15.1 1.0
CB A:GLU204 4.9 13.3 1.0

Manganese binding site 3 out of 3 in 2bb7

Go back to Manganese Binding Sites List in 2bb7
Manganese binding site 3 out of 3 in the Mn Form of E. Coli Methionine Aminopeptidase in Complex with A Quinolinyl Sulfonamide Inhibitor


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 3 of Mn Form of E. Coli Methionine Aminopeptidase in Complex with A Quinolinyl Sulfonamide Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn303

b:20.0
occ:1.00
 O A:HOH360 2.2 18.5 1.0
N1 A:QMS305 2.2 21.4 1.0
NE2 A:HIS79 2.3 19.3 1.0
O A:HOH341 2.3 17.8 1.0
N2 A:QMS305 2.3 18.6 1.0
O A:HOH309 2.4 19.0 1.0
C3 A:QMS305 3.0 21.4 1.0
C4 A:QMS305 3.0 21.5 1.0
O2 A:QMS305 3.2 20.6 1.0
CD2 A:HIS79 3.2 18.1 1.0
CE1 A:HIS79 3.3 17.5 1.0
S1 A:QMS305 3.3 19.9 1.0
C8 A:QMS305 3.3 23.2 1.0
O1 A:QMS305 4.0 24.4 1.0
O A:HOH365 4.0 30.7 1.0
NE2 A:HIS178 4.1 18.0 1.0
O A:HOH521 4.3 27.8 1.0
O A:HOH319 4.3 13.3 1.0
O A:HOH313 4.3 12.9 1.0
C2 A:QMS305 4.4 22.0 1.0
C5 A:QMS305 4.4 24.2 1.0
ND1 A:HIS79 4.4 19.1 1.0
CG A:HIS79 4.4 18.4 1.0
O A:HOH327 4.5 15.4 1.0
CE1 A:HIS178 4.6 22.1 1.0
C9 A:QMS305 4.6 22.7 1.0
OD2 A:ASP97 4.6 12.1 1.0
O A:HOH366 4.6 31.8 1.0
C7 A:QMS305 4.7 15.7 1.0
O A:HOH337 4.9 16.6 1.0

Reference:

M.Huang, S.X.Xie, Z.Q.Ma, R.P.Hanzlik, Q.Z.Ye. Metal Mediated Inhibition of Methionine Aminopeptidase By Quinolinyl Sulfonamides Biochem.Biophys.Res.Commun. V. 339 506 2006.
ISSN: ISSN 0006-291X
PubMed: 16300729
DOI: 10.1016/J.BBRC.2005.11.042
Page generated: Sat Oct 5 13:32:49 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy