Manganese in PDB 2alx: Ribonucleotide Reductase R2 From Escherichia Coli in Space Group P6(1)22

All present enzymatic activity of Ribonucleotide Reductase R2 From Escherichia Coli in Space Group P6(1)22:
1.17.4.1;

The structure of Ribonucleotide Reductase R2 From Escherichia Coli in Space Group P6(1)22, PDB code: 2alx was solved by M.Sommerhalter, L.Saleh, J.M.Bollinger Jr., A.C.Rosenzweig, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.27 / 2.60
Space group	P 61 2 2
Cell size a, b, c (Å), α, β, γ (°)	92.940, 92.940, 200.930, 90.00, 90.00, 120.00
R / Rfree (%)	22.7 / 27.6

The structure of Ribonucleotide Reductase R2 From Escherichia Coli in Space Group P6(1)22 also contains other interesting chemical elements:

Mercury

(Hg)

4 atoms

The binding sites of Manganese atom in the Ribonucleotide Reductase R2 From Escherichia Coli in Space Group P6(1)22 (pdb code 2alx). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the Ribonucleotide Reductase R2 From Escherichia Coli in Space Group P6(1)22, PDB code: 2alx:
Jump to Manganese binding site number: 1; 2;

Manganese binding site 1 out of 2 in the Ribonucleotide Reductase R2 From Escherichia Coli in Space Group P6(1)22


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Ribonucleotide Reductase R2 From Escherichia Coli in Space Group P6(1)22 within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn401 b:41.3 occ:1.00 OE1 A:GLU115 1.9 47.8 1.0 OE2 A:GLU238 1.9 50.6 1.0 OD1 A:ASP84 2.1 39.0 1.0 ND1 A:HIS118 2.3 36.2 1.0 OD2 A:ASP84 2.6 39.8 1.0 CG A:ASP84 2.7 40.9 1.0 CD A:GLU238 3.0 51.0 1.0 CD A:GLU115 3.0 43.2 1.0 CE1 A:HIS118 3.1 37.5 1.0 OE1 A:GLU238 3.3 55.0 1.0 CG A:HIS118 3.3 34.1 1.0 OE2 A:GLU115 3.5 42.1 1.0 CB A:HIS118 3.7 34.4 1.0 MN A:MN402 3.8 41.3 1.0 CZ A:PHE208 3.9 56.8 1.0 CB A:ASP84 4.1 40.2 1.0 CG2 A:ILE234 4.1 36.5 1.0 CG A:GLU115 4.2 42.5 1.0 NE2 A:HIS118 4.3 36.1 1.0 CG A:GLU238 4.3 48.8 1.0 CE2 A:PHE208 4.3 57.7 1.0 CA A:GLU115 4.3 41.3 1.0 CB A:GLU115 4.4 40.7 1.0 CD2 A:HIS118 4.4 35.6 1.0 CE1 A:PHE208 4.4 56.5 1.0 CE1 A:HIS241 4.7 35.1 1.0 OH A:TYR122 4.7 35.4 1.0 CA A:ASP84 4.9 36.5 1.0 ND1 A:HIS241 4.9 34.6 1.0 O A:GLU115 4.9 43.5 1.0

Manganese binding site 2 out of 2 in the Ribonucleotide Reductase R2 From Escherichia Coli in Space Group P6(1)22


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Ribonucleotide Reductase R2 From Escherichia Coli in Space Group P6(1)22 within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn402 b:41.3 occ:1.00 OE2 A:GLU115 1.8 42.1 1.0 OE1 A:GLU238 1.9 55.0 1.0 OE1 A:GLU204 2.0 47.7 1.0 ND1 A:HIS241 2.2 34.6 1.0 OE2 A:GLU204 2.5 47.2 1.0 CD A:GLU204 2.6 47.9 1.0 CD A:GLU115 2.9 43.2 1.0 CD A:GLU238 3.1 51.0 1.0 CE1 A:HIS241 3.1 35.1 1.0 CG A:HIS241 3.3 36.1 1.0 OE1 A:GLU115 3.3 47.8 1.0 OE2 A:GLU238 3.6 50.6 1.0 CB A:HIS241 3.6 38.9 1.0 NE1 A:TRP111 3.8 39.3 1.0 MN A:MN401 3.8 41.3 1.0 CG A:GLU204 4.1 51.1 1.0 CG A:GLU115 4.2 42.5 1.0 NE2 A:HIS241 4.2 37.2 1.0 CG A:GLU238 4.3 48.8 1.0 CA A:GLU238 4.3 41.1 1.0 CD2 A:HIS241 4.3 36.3 1.0 CD1 A:TRP111 4.4 39.3 1.0 CB A:GLU238 4.5 47.7 1.0 OD1 A:ASP84 4.6 39.0 1.0 CE2 A:PHE208 4.7 57.7 1.0 NE2 A:GLN87 4.7 39.1 1.0 CB A:GLU204 4.8 50.5 1.0 CG A:GLN87 4.9 40.9 1.0 CE2 A:TRP111 4.9 43.2 1.0 CD2 A:PHE208 4.9 56.5 1.0

M.Sommerhalter, L.Saleh, J.M.Bollinger, A.C.Rosenzweig. Structure of Escherichia Coli Ribonucleotide Reductase R2 in Space Group P6122. Acta Crystallogr.,Sect.D V. 61 1649 2005.
ISSN: ISSN 0907-4449
PubMed: 16301799
DOI: 10.1107/S0907444905034062