Atomistry » Manganese » PDB 2a7a-2axt » 2aeb
Atomistry »
  Manganese »
    PDB 2a7a-2axt »
      2aeb »

Manganese in PDB 2aeb: Crystal Structure of Human Arginase I at 1.29 A Resolution and Exploration of Inhibition in Immune Response.

Enzymatic activity of Crystal Structure of Human Arginase I at 1.29 A Resolution and Exploration of Inhibition in Immune Response.

All present enzymatic activity of Crystal Structure of Human Arginase I at 1.29 A Resolution and Exploration of Inhibition in Immune Response.:
3.5.3.1;

Protein crystallography data

The structure of Crystal Structure of Human Arginase I at 1.29 A Resolution and Exploration of Inhibition in Immune Response., PDB code: 2aeb was solved by L.Di Costanzo, G.Sabio, A.Mora, P.C.Rodriguez, A.C.Ochoa, F.Centeno, D.W.Christianson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) N/A / 1.29
Space group P 3
Cell size a, b, c (Å), α, β, γ (°) 91.422, 91.422, 69.637, 90.00, 90.00, 120.00
R / Rfree (%) 16.5 / 17.9

Manganese Binding Sites:

The binding sites of Manganese atom in the Crystal Structure of Human Arginase I at 1.29 A Resolution and Exploration of Inhibition in Immune Response. (pdb code 2aeb). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 4 binding sites of Manganese where determined in the Crystal Structure of Human Arginase I at 1.29 A Resolution and Exploration of Inhibition in Immune Response., PDB code: 2aeb:
Jump to Manganese binding site number: 1; 2; 3; 4;

Manganese binding site 1 out of 4 in 2aeb

Go back to Manganese Binding Sites List in 2aeb
Manganese binding site 1 out of 4 in the Crystal Structure of Human Arginase I at 1.29 A Resolution and Exploration of Inhibition in Immune Response.


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Crystal Structure of Human Arginase I at 1.29 A Resolution and Exploration of Inhibition in Immune Response. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn2362

b:7.7
occ:1.00
 O1 A:ABH551 2.1 11.8 1.0
OD1 A:ASP234 2.2 8.5 1.0
OD1 A:ASP124 2.2 7.6 1.0
ND1 A:HIS126 2.2 8.0 1.0
OD2 A:ASP232 2.3 7.4 1.0
OD2 A:ASP234 2.4 8.6 1.0
CG A:ASP234 2.7 9.6 1.0
HO1 A:ABH551 2.7 17.7 1.0
O3 A:ABH551 2.8 13.7 1.0
HB2 A:HIS126 3.0 8.9 1.0
B A:ABH551 3.1 10.9 1.0
CG A:ASP232 3.1 6.5 1.0
CG A:ASP124 3.1 6.5 1.0
CE1 A:HIS126 3.2 7.7 1.0
CG A:HIS126 3.3 10.7 1.0
HE1 A:HIS126 3.3 9.3 1.0
MN A:MN2363 3.3 7.9 1.0
OD2 A:ASP124 3.5 8.4 1.0
HO3 A:ABH551 3.5 20.6 1.0
H A:HIS126 3.6 9.6 1.0
CB A:HIS126 3.6 7.4 1.0
OD1 A:ASP232 3.7 7.9 1.0
HCD1 A:ABH551 3.7 20.1 1.0
H A:ALA125 3.8 10.1 1.0
O2 A:ABH551 3.9 12.2 1.0
HB3 A:ALA125 3.9 11.3 1.0
HB3 A:ASP232 4.0 8.4 1.0
N A:HIS126 4.1 8.0 1.0
CB A:ASP234 4.2 9.0 1.0
CB A:ASP232 4.2 7.0 1.0
CE A:ABH551 4.2 14.1 1.0
HB3 A:HIS126 4.3 8.9 1.0
NE2 A:HIS126 4.3 8.5 1.0
N A:ALA125 4.3 8.4 1.0
CD2 A:HIS126 4.4 8.0 1.0
CD A:ABH551 4.4 16.8 1.0
HB A:THR246 4.4 13.4 1.0
HB2 A:ASP232 4.4 8.4 1.0
HA A:ASP124 4.4 7.4 1.0
CB A:ASP124 4.5 7.9 1.0
HB3 A:ASP234 4.5 10.8 1.0
OD1 A:ASP128 4.5 8.9 1.0
CA A:HIS126 4.5 8.9 1.0
HO2 A:ABH551 4.6 18.2 1.0
HCE2 A:ABH551 4.6 17.0 1.0
HB2 A:ASP234 4.6 10.8 1.0
O A:HOH2465 4.6 9.4 1.0
HG3 A:GLU277 4.6 14.0 1.0
CB A:ALA125 4.7 7.5 1.0
HCD2 A:ABH551 4.8 20.1 1.0
OD2 A:ASP128 4.8 7.1 1.0
CA A:ASP124 4.8 6.2 1.0
H A:ASP234 4.8 10.8 1.0
O A:HOH2391 4.9 15.2 1.0
CA A:ALA125 4.9 7.6 1.0
HB3 A:ASP124 4.9 9.5 1.0
HCE1 A:ABH551 4.9 17.0 1.0
C A:ALA125 4.9 6.7 1.0
C A:ASP124 5.0 7.5 1.0

Manganese binding site 2 out of 4 in 2aeb

Go back to Manganese Binding Sites List in 2aeb
Manganese binding site 2 out of 4 in the Crystal Structure of Human Arginase I at 1.29 A Resolution and Exploration of Inhibition in Immune Response.


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Crystal Structure of Human Arginase I at 1.29 A Resolution and Exploration of Inhibition in Immune Response. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn2363

b:7.9
occ:1.00
 OD2 A:ASP124 2.1 8.4 1.0
OD2 A:ASP128 2.1 7.1 1.0
ND1 A:HIS101 2.2 6.8 1.0
O1 A:ABH551 2.2 11.8 1.0
OD2 A:ASP232 2.2 7.4 1.0
O2 A:ABH551 2.3 12.2 1.0
HO1 A:ABH551 2.4 17.7 1.0
HO2 A:ABH551 2.7 18.2 1.0
B A:ABH551 2.8 10.9 1.0
CG A:ASP128 3.0 5.9 1.0
CG A:ASP124 3.0 6.5 1.0
HB2 A:ASP232 3.0 8.4 1.0
CE1 A:HIS101 3.2 8.3 1.0
CG A:HIS101 3.2 9.1 1.0
CG A:ASP232 3.3 6.5 1.0
HB2 A:HIS101 3.3 10.7 1.0
MN A:MN2362 3.3 7.7 1.0
HE1 A:HIS101 3.3 10.0 1.0
OD1 A:ASP128 3.4 8.9 1.0
OD1 A:ASP124 3.4 7.6 1.0
HB3 A:HIS101 3.4 10.7 1.0
CB A:HIS101 3.5 8.9 1.0
O3 A:ABH551 3.5 13.7 1.0
CB A:ASP232 3.6 7.0 1.0
HE1 A:TRP122 3.7 10.4 1.0
HB3 A:ASP232 3.8 8.4 1.0
HB2 A:HIS126 3.9 8.9 1.0
HZ2 A:TRP122 4.0 10.6 1.0
HCE2 A:ABH551 4.1 17.0 1.0
HG3 A:GLU277 4.1 14.0 1.0
CE A:ABH551 4.1 14.1 1.0
NE2 A:HIS101 4.3 9.8 1.0
HO3 A:ABH551 4.3 20.6 1.0
CD2 A:HIS101 4.3 8.5 1.0
OD1 A:ASP232 4.4 7.9 1.0
NE1 A:TRP122 4.4 8.7 1.0
CB A:ASP124 4.4 7.9 1.0
CB A:ASP128 4.4 10.7 1.0
HB2 A:ASP124 4.5 9.5 1.0
O A:HIS141 4.5 9.3 1.0
HCE1 A:ABH551 4.6 17.0 1.0
HB2 A:ASP128 4.6 12.8 1.0
CZ2 A:TRP122 4.6 8.8 1.0
HB3 A:ASP128 4.7 12.8 1.0
CE2 A:TRP122 4.9 7.9 1.0
HB3 A:ASP124 4.9 9.5 1.0
CB A:HIS126 4.9 7.4 1.0
HG2 A:GLU277 4.9 14.0 1.0
CG A:GLU277 4.9 11.6 1.0
CA A:ASP232 5.0 4.6 1.0

Manganese binding site 3 out of 4 in 2aeb

Go back to Manganese Binding Sites List in 2aeb
Manganese binding site 3 out of 4 in the Crystal Structure of Human Arginase I at 1.29 A Resolution and Exploration of Inhibition in Immune Response.


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 3 of Crystal Structure of Human Arginase I at 1.29 A Resolution and Exploration of Inhibition in Immune Response. within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mn1362

b:10.6
occ:1.00
 OD2 B:ASP234 2.1 12.0 1.0
O1 B:ABH552 2.2 10.9 1.0
OD1 B:ASP124 2.2 9.9 1.0
ND1 B:HIS126 2.3 11.0 1.0
OD2 B:ASP232 2.3 10.7 1.0
OD1 B:ASP234 2.4 12.7 1.0
CG B:ASP234 2.6 14.3 1.0
O3 B:ABH552 2.7 15.2 1.0
HO1 B:ABH552 2.9 16.3 1.0
B B:ABH552 3.1 15.7 1.0
CG B:ASP232 3.1 13.6 1.0
HB2 B:HIS126 3.1 14.1 1.0
CG B:ASP124 3.2 8.4 1.0
CE1 B:HIS126 3.2 10.0 1.0
HE1 B:HIS126 3.3 12.0 1.0
CG B:HIS126 3.3 9.1 1.0
MN B:MN1363 3.3 11.2 1.0
HO3 B:ABH552 3.5 22.8 1.0
OD2 B:ASP124 3.6 9.8 1.0
OD1 B:ASP232 3.6 12.7 1.0
H B:HIS126 3.7 13.9 1.0
CB B:HIS126 3.7 11.7 1.0
HCD1 B:ABH552 3.7 21.3 1.0
H B:ALA125 3.8 10.3 1.0
O2 B:ABH552 3.9 15.4 1.0
HB3 B:ALA125 4.0 15.1 1.0
HB3 B:ASP232 4.0 15.5 1.0
CB B:ASP234 4.1 9.0 1.0
CB B:ASP232 4.2 12.9 1.0
CE B:ABH552 4.2 18.8 1.0
N B:HIS126 4.2 11.6 1.0
NE2 B:HIS126 4.3 13.7 1.0
CD B:ABH552 4.3 17.8 1.0
N B:ALA125 4.4 8.6 1.0
HB B:THR246 4.4 17.5 1.0
CD2 B:HIS126 4.4 10.9 1.0
HB2 B:ASP232 4.4 15.5 1.0
HCD2 B:ABH552 4.4 21.3 1.0
HB3 B:HIS126 4.4 14.1 1.0
HA B:ASP124 4.5 10.9 1.0
HB2 B:ASP234 4.5 10.8 1.0
CB B:ASP124 4.5 11.2 1.0
HB3 B:ASP234 4.5 10.8 1.0
OD2 B:ASP128 4.6 10.8 1.0
O B:HOH1383 4.6 12.9 1.0
HG3 B:GLU277 4.6 16.3 1.0
CA B:HIS126 4.6 10.9 1.0
HCE2 B:ABH552 4.6 22.5 1.0
HO2 B:ABH552 4.6 23.1 1.0
CB B:ALA125 4.8 10.1 1.0
CA B:ASP124 4.8 9.1 1.0
H B:ASP234 4.8 12.3 1.0
OD1 B:ASP128 4.9 10.1 1.0
O B:HOH1453 4.9 18.6 1.0
HCE1 B:ABH552 4.9 22.5 1.0
CA B:ALA125 4.9 10.5 1.0
C B:ALA125 4.9 9.1 1.0
HB3 B:ASP124 5.0 13.5 1.0
C B:ASP124 5.0 9.1 1.0

Manganese binding site 4 out of 4 in 2aeb

Go back to Manganese Binding Sites List in 2aeb
Manganese binding site 4 out of 4 in the Crystal Structure of Human Arginase I at 1.29 A Resolution and Exploration of Inhibition in Immune Response.


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 4 of Crystal Structure of Human Arginase I at 1.29 A Resolution and Exploration of Inhibition in Immune Response. within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mn1363

b:11.2
occ:1.00
 O1 B:ABH552 2.1 10.9 1.0
OD1 B:ASP128 2.1 10.1 1.0
OD2 B:ASP124 2.2 9.8 1.0
OD2 B:ASP232 2.2 10.7 1.0
ND1 B:HIS101 2.2 13.0 1.0
HO1 B:ABH552 2.3 16.3 1.0
O2 B:ABH552 2.3 15.4 1.0
HO2 B:ABH552 2.6 23.1 1.0
B B:ABH552 2.8 15.7 1.0
HB2 B:ASP232 3.0 15.5 1.0
CG B:ASP124 3.0 8.4 1.0
CG B:ASP128 3.1 9.2 1.0
CE1 B:HIS101 3.2 11.4 1.0
CG B:ASP232 3.2 13.6 1.0
CG B:HIS101 3.2 11.0 1.0
HB2 B:HIS101 3.2 16.4 1.0
HE1 B:HIS101 3.3 13.7 1.0
MN B:MN1362 3.3 10.6 1.0
OD1 B:ASP124 3.4 9.9 1.0
OD2 B:ASP128 3.4 10.8 1.0
HB3 B:HIS101 3.5 16.4 1.0
CB B:ASP232 3.5 12.9 1.0
CB B:HIS101 3.5 13.6 1.0
O3 B:ABH552 3.6 15.2 1.0
HE1 B:TRP122 3.6 13.3 1.0
HB3 B:ASP232 3.8 15.5 1.0
HZ2 B:TRP122 3.9 14.2 1.0
HCE2 B:ABH552 4.0 22.5 1.0
HB2 B:HIS126 4.0 14.1 1.0
HG3 B:GLU277 4.1 16.3 1.0
CE B:ABH552 4.1 18.8 1.0
NE2 B:HIS101 4.3 9.8 1.0
HO3 B:ABH552 4.3 22.8 1.0
NE1 B:TRP122 4.3 11.1 1.0
CD2 B:HIS101 4.4 10.9 1.0
OD1 B:ASP232 4.4 12.7 1.0
CB B:ASP124 4.4 11.2 1.0
HB2 B:ASP124 4.4 13.5 1.0
CB B:ASP128 4.5 10.4 1.0
O B:HIS141 4.6 11.7 1.0
HB2 B:ASP128 4.6 12.4 1.0
HCE1 B:ABH552 4.6 22.5 1.0
CZ2 B:TRP122 4.6 11.8 1.0
HB3 B:ASP128 4.7 12.4 1.0
CE2 B:TRP122 4.8 14.0 1.0
HB3 B:ASP124 4.9 13.5 1.0
OD1 B:ASP234 4.9 12.7 1.0
HG2 B:GLU277 4.9 16.3 1.0
CG B:GLU277 4.9 13.6 1.0
CA B:ASP232 4.9 10.0 1.0
CB B:HIS126 5.0 11.7 1.0
HCD1 B:ABH552 5.0 21.3 1.0
OD2 B:ASP234 5.0 12.0 1.0
OE2 B:GLU277 5.0 14.5 1.0

Reference:

L.Di Costanzo, G.Sabio, A.Mora, P.C.Rodriguez, A.C.Ochoa, F.Centeno, D.W.Christianson. Crystal Structure of Human Arginase I at 1.29 A Resolution and Exploration of Inhibition in the Immune Response. Proc.Natl.Acad.Sci.Usa V. 102 13058 2005.
ISSN: ISSN 0027-8424
PubMed: 16141327
DOI: 10.1073/PNAS.0504027102
Page generated: Tue Dec 15 03:59:15 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy