Manganese in PDB 1yw7: H-METAP2 Complexed with A444148

All present enzymatic activity of H-METAP2 Complexed with A444148:
3.4.11.18;

The structure of H-METAP2 Complexed with A444148, PDB code: 1yw7 was solved by C.H.Park, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	15.34 / 1.85
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	89.487, 98.735, 101.211, 90.00, 90.00, 90.00
R / Rfree (%)	n/a / n/a

The binding sites of Manganese atom in the H-METAP2 Complexed with A444148 (pdb code 1yw7). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the H-METAP2 Complexed with A444148, PDB code: 1yw7:
Jump to Manganese binding site number: 1; 2;

Manganese binding site 1 out of 2 in the H-METAP2 Complexed with A444148


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of H-METAP2 Complexed with A444148 within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn480 b:25.8 occ:1.00 OD2 A:ASP262 2.1 18.3 1.0 OD2 A:ASP251 2.2 15.0 1.0 OE2 A:GLU459 2.3 17.1 1.0 OD1 A:ASP251 2.3 14.5 1.0 O A:HOH678 2.4 26.9 1.0 CG A:ASP251 2.5 14.7 1.0 CG A:ASP262 3.0 17.9 1.0 CD A:GLU459 3.1 17.2 1.0 OD1 A:ASP262 3.2 18.8 1.0 OE1 A:GLU459 3.3 16.9 1.0 MN A:MN481 3.4 28.3 1.0 CB A:ASP251 4.0 14.6 1.0 CZ A:PHE219 4.1 14.8 1.0 OE2 A:GLU364 4.1 18.9 1.0 NE2 A:GLN457 4.1 16.5 1.0 O18 A:A41482 4.3 35.7 1.0 O19 A:A41482 4.3 35.7 1.0 CE2 A:PHE219 4.3 14.6 1.0 CB A:ASP262 4.4 17.8 1.0 CG A:GLU459 4.5 16.9 1.0 CB A:ALA264 4.6 16.7 1.0 C17 A:A41482 4.6 35.9 1.0 N A:CYS263 4.7 16.9 1.0 C A:ASP262 4.7 17.1 1.0 CD A:GLU364 4.7 19.1 1.0 CA A:ASP262 4.8 17.3 1.0 OE1 A:GLU364 4.8 19.4 1.0 CA A:ASP251 4.9 14.3 1.0 CE1 A:PHE219 5.0 14.8 1.0 CB A:GLU459 5.0 16.6 1.0

Manganese binding site 2 out of 2 in the H-METAP2 Complexed with A444148


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of H-METAP2 Complexed with A444148 within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn481 b:28.3 occ:1.00 OD1 A:ASP262 2.2 18.8 1.0 OE1 A:GLU459 2.3 16.9 1.0 OE1 A:GLU364 2.3 19.4 1.0 O19 A:A41482 2.3 35.7 1.0 NE2 A:HIS331 2.4 21.0 1.0 CD A:GLU364 3.1 19.1 1.0 CG A:ASP262 3.2 17.9 1.0 CD2 A:HIS331 3.3 21.1 1.0 CD A:GLU459 3.3 17.2 1.0 OE2 A:GLU364 3.4 18.9 1.0 MN A:MN480 3.4 25.8 1.0 CE1 A:HIS331 3.4 21.1 1.0 C17 A:A41482 3.5 35.9 1.0 OE2 A:GLU459 3.6 17.1 1.0 OD2 A:ASP262 3.7 18.3 1.0 O18 A:A41482 3.9 35.7 1.0 CB A:ALA362 3.9 18.8 1.0 C5 A:A41482 4.1 36.6 1.0 O A:HOH678 4.2 26.9 1.0 CB A:ASP262 4.3 17.8 1.0 CG A:GLU364 4.3 18.8 1.0 CG A:HIS331 4.5 21.0 1.0 C6 A:A41482 4.5 36.5 1.0 ND1 A:HIS331 4.5 20.9 1.0 CG A:GLU459 4.6 16.9 1.0 N8 A:A41482 4.7 36.5 1.0 C16 A:A41482 4.8 36.0 1.0 CD1 A:ILE338 5.0 24.2 1.0 C4 A:A41482 5.0 36.6 1.0

G.S.Sheppard, J.Wang, M.Kawai, S.D.Fidanze, N.Y.Bamaung, S.A.Erickson, D.M.Barnes, J.S.Tedrow, L.Kolaczkowski, A.Vasudevan, D.C.Park, G.T.Wang, W.J.Sanders, R.A.Mantei, F.Palazzo, L.Tucker-Garcia, P.Lou, Q.Zhang, C.H.Park, K.H.Kim, A.Petros, E.Olejniczak, D.Nettesheim, P.Hajduk, J.Henkin, R.Lesniewski, S.K.Davidsen, R.L.Bell. Discovery and Optimization of Anthranilic Acid Sulfonamides As Inhibitors of Methionine Aminopeptidase-2: A Structural Basis For the Reduction of Albumin Binding. J.Med.Chem. V. 49 3832 2006.
ISSN: ISSN 0022-2623
PubMed: 16789740
DOI: 10.1021/JM0601001