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Manganese in PDB 1vzx: Roles of Active Site Tryptophans in Substrate Binding and Catalysis By Alpha-1,3 Galactosyltransferase

Enzymatic activity of Roles of Active Site Tryptophans in Substrate Binding and Catalysis By Alpha-1,3 Galactosyltransferase

All present enzymatic activity of Roles of Active Site Tryptophans in Substrate Binding and Catalysis By Alpha-1,3 Galactosyltransferase:
2.4.1.151;

Protein crystallography data

The structure of Roles of Active Site Tryptophans in Substrate Binding and Catalysis By Alpha-1,3 Galactosyltransferase, PDB code: 1vzx was solved by Y.Zhang, A.Deshpande, Z.Xie, R.Natesh, K.R.Acharya, K.Brew, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 1.97
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 45.220, 94.480, 94.447, 90.00, 99.00, 90.00
R / Rfree (%) 15.4 / 20.2

Manganese Binding Sites:

The binding sites of Manganese atom in the Roles of Active Site Tryptophans in Substrate Binding and Catalysis By Alpha-1,3 Galactosyltransferase (pdb code 1vzx). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the Roles of Active Site Tryptophans in Substrate Binding and Catalysis By Alpha-1,3 Galactosyltransferase, PDB code: 1vzx:
Jump to Manganese binding site number: 1; 2;

Manganese binding site 1 out of 2 in 1vzx

Go back to Manganese Binding Sites List in 1vzx
Manganese binding site 1 out of 2 in the Roles of Active Site Tryptophans in Substrate Binding and Catalysis By Alpha-1,3 Galactosyltransferase


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Roles of Active Site Tryptophans in Substrate Binding and Catalysis By Alpha-1,3 Galactosyltransferase within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn1371

b:13.8
occ:1.00
O1B A:UDP1372 2.1 9.8 1.0
OD1 A:ASP227 2.2 10.3 1.0
OD2 A:ASP225 2.2 8.2 1.0
O A:HOH2321 2.3 20.0 1.0
O1A A:UDP1372 2.4 12.1 1.0
OD2 A:ASP227 2.4 9.2 1.0
CG A:ASP227 2.7 10.8 1.0
CG A:ASP225 3.2 10.1 1.0
PB A:UDP1372 3.3 12.8 1.0
O3A A:UDP1372 3.3 13.5 1.0
PA A:UDP1372 3.4 13.5 1.0
CB A:ASP225 3.6 10.1 1.0
NZ A:LYS359 3.7 7.7 1.0
O3B A:UDP1372 3.8 12.8 1.0
O3' A:UDP1372 3.8 11.4 1.0
O A:HOH2320 4.0 19.8 1.0
CB A:ASP227 4.2 8.4 1.0
O A:HOH2318 4.2 13.2 1.0
O5' A:UDP1372 4.2 13.6 1.0
C5' A:UDP1372 4.3 12.3 1.0
OD1 A:ASP225 4.3 10.8 1.0
O A:HOH2305 4.4 10.8 1.0
O A:HOH2173 4.4 11.8 1.0
O2B A:UDP1372 4.5 13.5 1.0
O A:HOH2172 4.5 35.7 1.0
C3' A:UDP1372 4.6 10.2 1.0
O A:HOH2174 4.6 10.6 1.0
O2A A:UDP1372 4.6 13.3 1.0
O A:ASP227 4.8 11.5 1.0
C4' A:UDP1372 4.8 11.1 1.0
CB A:ALA282 4.8 7.5 1.0
N A:ASP227 4.9 9.3 1.0
CA A:ASP227 5.0 11.0 1.0
CA A:ASP225 5.0 9.5 1.0

Manganese binding site 2 out of 2 in 1vzx

Go back to Manganese Binding Sites List in 1vzx
Manganese binding site 2 out of 2 in the Roles of Active Site Tryptophans in Substrate Binding and Catalysis By Alpha-1,3 Galactosyltransferase


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Roles of Active Site Tryptophans in Substrate Binding and Catalysis By Alpha-1,3 Galactosyltransferase within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mn2371

b:12.8
occ:1.00
O1B B:UDP2372 2.1 10.9 1.0
OD1 B:ASP1227 2.2 11.9 1.0
OD2 B:ASP1225 2.3 9.7 1.0
O1A B:UDP2372 2.3 10.1 1.0
O B:HOH2314 2.3 8.4 1.0
OD2 B:ASP1227 2.5 8.9 1.0
CG B:ASP1227 2.7 11.0 1.0
CG B:ASP1225 3.2 9.1 1.0
PB B:UDP2372 3.3 12.7 1.0
O3A B:UDP2372 3.3 12.2 1.0
PA B:UDP2372 3.4 11.7 1.0
CB B:ASP1225 3.5 9.1 1.0
O3B B:UDP2372 3.7 12.1 1.0
NZ B:LYS1359 3.8 8.4 1.0
O3' B:UDP2372 3.8 11.3 1.0
O B:HOH2311 4.1 23.2 1.0
O B:HOH2296 4.1 13.6 1.0
CB B:ASP1227 4.2 9.6 1.0
O5' B:UDP2372 4.3 12.5 1.0
OD1 B:ASP1225 4.3 11.7 1.0
O B:HOH2291 4.4 10.8 1.0
C5' B:UDP2372 4.5 11.3 1.0
O B:HOH2142 4.5 34.2 1.0
O B:HOH2147 4.5 19.2 1.0
O2B B:UDP2372 4.5 13.6 1.0
O2A B:UDP2372 4.6 11.2 1.0
C3' B:UDP2372 4.6 9.7 1.0
O B:HOH2148 4.6 5.8 1.0
O B:ASP1227 4.7 7.1 1.0
CB B:ALA1282 4.7 6.7 1.0
C4' B:UDP2372 4.9 8.3 1.0
N B:ASP1227 4.9 7.3 1.0
CA B:ASP1225 4.9 10.2 1.0
CA B:ASP1227 5.0 8.6 1.0

Reference:

Y.Zhang, A.Deshpande, Z.Xie, R.Natesh, K.R.Acharya, K.Brew. Roles of Active Site Tryptophans in Substrate Binding and Catalysis By Alpha-1,3 Galactosyltransferase. Glycobiology V. 14 1295 2004.
ISSN: ISSN 0959-6658
PubMed: 15229192
DOI: 10.1093/GLYCOB/CWH119
Page generated: Tue Dec 15 03:57:10 2020

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