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Manganese in PDB 1uvm: The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 5NT Rna Conformation A

Enzymatic activity of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 5NT Rna Conformation A

All present enzymatic activity of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 5NT Rna Conformation A:
2.7.7.48;

Protein crystallography data

The structure of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 5NT Rna Conformation A, PDB code: 1uvm was solved by P.S.Salgado, E.V.Makeyev, S.Butcher, D.Bamford, D.I.Stuart, J.M.Grimes, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.82 / 2.00
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 105.946, 91.881, 140.762, 90.00, 101.56, 90.00
R / Rfree (%) 24.1 / 27.6

Manganese Binding Sites:

The binding sites of Manganese atom in the The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 5NT Rna Conformation A (pdb code 1uvm). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 3 binding sites of Manganese where determined in the The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 5NT Rna Conformation A, PDB code: 1uvm:
Jump to Manganese binding site number: 1; 2; 3;

Manganese binding site 1 out of 3 in 1uvm

Go back to Manganese Binding Sites List in 1uvm
Manganese binding site 1 out of 3 in the The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 5NT Rna Conformation A


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 5NT Rna Conformation A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn1665

b:35.9
occ:1.00
 OE1 A:GLU491 2.1 31.5 1.0
O A:ALA495 2.1 41.9 1.0
O A:HOH2158 2.2 34.4 1.0
OD1 A:ASP454 2.2 36.7 1.0
O A:HOH2116 2.4 41.4 1.0
CD A:GLU491 3.0 34.5 1.0
CG A:ASP454 3.1 41.1 1.0
C A:ALA495 3.2 40.1 1.0
OD2 A:ASP454 3.4 38.6 1.0
OE2 A:GLU491 3.4 35.0 1.0
O A:THR323 3.9 38.1 1.0
N A:ALA495 4.0 38.2 1.0
N A:PHE496 4.1 34.8 1.0
CA A:ALA495 4.1 37.1 1.0
CA A:PHE496 4.2 35.3 1.0
CG A:GLU491 4.3 36.1 1.0
CB A:ASP454 4.4 39.8 1.0
O A:ALA455 4.5 34.2 1.0
CB A:GLU491 4.5 36.6 1.0
CB A:ALA495 4.5 37.7 1.0
N A:ALA455 4.6 34.4 1.0
CA A:ASP454 4.7 40.4 1.0

Manganese binding site 2 out of 3 in 1uvm

Go back to Manganese Binding Sites List in 1uvm
Manganese binding site 2 out of 3 in the The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 5NT Rna Conformation A


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 5NT Rna Conformation A within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mn1665

b:38.5
occ:1.00
 OD1 B:ASP454 2.0 35.4 1.0
OE1 B:GLU491 2.0 37.5 1.0
O B:HOH2180 2.1 41.4 1.0
O B:HOH2179 2.2 39.2 1.0
O B:HOH2181 2.2 32.4 1.0
O B:ALA495 2.2 37.2 1.0
CD B:GLU491 3.0 37.7 1.0
CG B:ASP454 3.1 39.5 1.0
C B:ALA495 3.3 37.3 1.0
OE2 B:GLU491 3.3 41.0 1.0
OD2 B:ASP454 3.5 38.1 1.0
O B:THR323 3.8 36.6 1.0
N B:ALA495 4.0 36.6 1.0
CA B:ALA495 4.1 39.4 1.0
N B:PHE496 4.2 37.8 1.0
CG B:GLU491 4.2 35.9 1.0
CA B:PHE496 4.3 38.1 1.0
CB B:ASP454 4.3 39.8 1.0
CB B:GLU491 4.5 33.1 1.0
O B:ALA455 4.5 37.1 1.0
CB B:ALA495 4.5 42.3 1.0
N B:ALA455 4.5 35.4 1.0
CA B:ASP454 4.6 39.8 1.0

Manganese binding site 3 out of 3 in 1uvm

Go back to Manganese Binding Sites List in 1uvm
Manganese binding site 3 out of 3 in the The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 5NT Rna Conformation A


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 3 of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 5NT Rna Conformation A within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Mn1665

b:40.8
occ:1.00
 OE1 C:GLU491 1.9 33.5 1.0
OD1 C:ASP454 2.1 36.3 1.0
O C:HOH2097 2.2 35.6 1.0
O C:ALA495 2.3 39.7 1.0
O C:HOH2099 2.4 36.5 1.0
O C:HOH2098 2.4 32.2 1.0
CD C:GLU491 3.0 38.6 1.0
CG C:ASP454 3.1 40.9 1.0
C C:ALA495 3.3 39.0 1.0
OE2 C:GLU491 3.4 41.9 1.0
OD2 C:ASP454 3.5 34.8 1.0
O C:THR323 3.9 38.4 1.0
N C:ALA495 4.0 40.3 1.0
N C:PHE496 4.2 38.4 1.0
CA C:ALA495 4.2 41.4 1.0
CG C:GLU491 4.2 36.1 1.0
CA C:PHE496 4.3 37.5 1.0
CB C:GLU491 4.4 37.9 1.0
CB C:ASP454 4.4 38.9 1.0
O C:ALA455 4.5 37.6 1.0
N C:ALA455 4.6 38.7 1.0
CB C:ALA495 4.6 41.5 1.0
CA C:ASP454 4.7 40.1 1.0

Reference:

P.S.Salgado, E.V.Makeyev, S.J.Butcher, D.H.Bamford, D.I.Stuart, J.M.Grimes. The Structural Basis For Rna Specificity and CA2+ Inhibition of An Rna-Dependent Rna Polymerase. Structure V. 12 307 2004.
ISSN: ISSN 0969-2126
PubMed: 14962391
DOI: 10.1016/J.STR.2004.01.012
Page generated: Sat Oct 5 12:40:45 2024

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