Manganese in PDB 1uvl: The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 5NT Rna. Conformation B

Enzymatic activity of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 5NT Rna. Conformation B

All present enzymatic activity of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 5NT Rna. Conformation B:
2.7.7.48;

Protein crystallography data

The structure of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 5NT Rna. Conformation B, PDB code: 1uvl was solved by P.S.Salgado, E.V.Makeyev, S.Butcher, D.Bamford, D.I.Stuart, J.M.Grimes, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	19.82 / 2.00
*Space group*	P 1 2₁ 1
*Cell size a, b, c (Å), α, β, γ (°)*	105.946, 91.881, 140.762, 90.00, 101.56, 90.00
*R / R_free (%)*	28.1 / 29.9

Manganese Binding Sites:

The binding sites of Manganese atom in the The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 5NT Rna. Conformation B (pdb code 1uvl). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 3 binding sites of Manganese where determined in the The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 5NT Rna. Conformation B, PDB code: 1uvl:
Jump to Manganese binding site number: 1; 2; 3;

Manganese binding site 1 out of 3 in 1uvl

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Manganese Binding Sites List in 1uvl

Manganese binding site 1 out of 3 in the The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 5NT Rna. Conformation B

Mono view

Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 5NT Rna. Conformation B within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Mn1665 b:39.5 occ:1.00	OE1	A:GLU491	2.0	32.1	1.0
	OD1	A:ASP454	2.0	34.4	1.0
	O	A:ALA495	2.2	39.5	1.0
	CD	A:GLU491	2.9	34.5	1.0
	CG	A:ASP454	3.0	40.6	1.0
	C	A:ALA495	3.3	38.4	1.0
	OE2	A:GLU491	3.3	39.8	1.0
	OD2	A:ASP454	3.4	34.2	1.0
	O	A:THR323	3.8	37.2	1.0
	N	A:ALA495	4.0	37.3	1.0
	CA	A:ALA495	4.2	39.3	1.0
	N	A:PHE496	4.2	37.6	1.0
	CG	A:GLU491	4.2	35.1	1.0
	CA	A:PHE496	4.3	37.6	1.0
	CB	A:ASP454	4.4	40.0	1.0
	CB	A:GLU491	4.4	34.3	1.0
	O	A:ALA455	4.5	36.0	1.0
	CB	A:ALA495	4.6	39.2	1.0
	N	A:ALA455	4.6	36.0	1.0
	CA	A:ASP454	4.7	41.5	1.0

Manganese binding site 2 out of 3 in 1uvl

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Manganese Binding Sites List in 1uvl

Manganese binding site 2 out of 3 in the The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 5NT Rna. Conformation B

Mono view

Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 5NT Rna. Conformation B within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
C:Mn1665 b:39.5 occ:1.00	OE1	C:GLU491	2.0	32.1	1.0
	OD1	C:ASP454	2.0	34.4	1.0
	O	C:ALA495	2.2	39.5	1.0
	CD	C:GLU491	2.9	34.5	1.0
	CG	C:ASP454	3.0	40.6	1.0
	C	C:ALA495	3.3	38.4	1.0
	OE2	C:GLU491	3.3	39.8	1.0
	OD2	C:ASP454	3.4	34.2	1.0
	O	C:THR323	3.8	37.2	1.0
	N	C:ALA495	4.0	37.3	1.0
	CA	C:ALA495	4.2	39.3	1.0
	N	C:PHE496	4.2	37.6	1.0
	CG	C:GLU491	4.2	35.1	1.0
	CA	C:PHE496	4.3	37.6	1.0
	CB	C:ASP454	4.4	40.0	1.0
	CB	C:GLU491	4.4	34.3	1.0
	O	C:ALA455	4.5	36.0	1.0
	CB	C:ALA495	4.6	39.2	1.0
	N	C:ALA455	4.6	36.0	1.0
	CA	C:ASP454	4.7	41.5	1.0

Manganese binding site 3 out of 3 in 1uvl

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Manganese Binding Sites List in 1uvl

Manganese binding site 3 out of 3 in the The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 5NT Rna. Conformation B

Mono view

Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 3 of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 5NT Rna. Conformation B within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
E:Mn1665 b:39.5 occ:1.00	OE1	E:GLU491	2.0	32.1	1.0
	OD1	E:ASP454	2.0	34.4	1.0
	O	E:ALA495	2.2	39.5	1.0
	CD	E:GLU491	2.9	34.5	1.0
	CG	E:ASP454	3.0	40.6	1.0
	C	E:ALA495	3.3	38.4	1.0
	OE2	E:GLU491	3.3	39.8	1.0
	OD2	E:ASP454	3.4	34.2	1.0
	O	E:THR323	3.8	37.2	1.0
	N	E:ALA495	4.0	37.3	1.0
	CA	E:ALA495	4.2	39.3	1.0
	N	E:PHE496	4.2	37.6	1.0
	CG	E:GLU491	4.2	35.1	1.0
	CA	E:PHE496	4.3	37.6	1.0
	CB	E:ASP454	4.4	40.0	1.0
	CB	E:GLU491	4.4	34.3	1.0
	O	E:ALA455	4.5	36.0	1.0
	CB	E:ALA495	4.6	39.2	1.0
	N	E:ALA455	4.6	36.0	1.0
	CA	E:ASP454	4.7	41.5	1.0

Reference:

P.S.Salgado, E.V.Makeyev, S.J.Butcher, D.H.Bamford, D.I.Stuart, J.M.Grimes. The Structural Basis For Rna Specificity and CA2+ Inhibition of An Rna-Dependent Rna Polymerase. Structure V. 12 307 2004.
ISSN: ISSN 0969-2126
PubMed: 14962391
DOI: 10.1016/J.STR.2004.01.012

Page generated: Sat Oct 5 12:40:45 2024

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