Manganese in PDB 1uvk: The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 Dead-End Complex

Enzymatic activity of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 Dead-End Complex

All present enzymatic activity of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 Dead-End Complex:
2.7.7.48;

Protein crystallography data

The structure of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 Dead-End Complex, PDB code: 1uvk was solved by P.S.Salgado, E.V.Makeyev, S.Butcher, D.Bamford, D.I.Stuart, J.M.Grimes, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	19.98 / 2.45
*Space group*	P 1 2₁ 1
*Cell size a, b, c (Å), α, β, γ (°)*	106.290, 93.800, 140.770, 90.00, 101.35, 90.00
*R / R_free (%)*	24.3 / 26.5

Other elements in 1uvk:

The structure of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 Dead-End Complex also contains other interesting chemical elements:

Magnesium

(Mg)

6 atoms

Manganese Binding Sites:

The binding sites of Manganese atom in the The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 Dead-End Complex (pdb code 1uvk). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 3 binding sites of Manganese where determined in the The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 Dead-End Complex, PDB code: 1uvk:
Jump to Manganese binding site number: 1; 2; 3;

Manganese binding site 1 out of 3 in 1uvk

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Manganese Binding Sites List in 1uvk

Manganese binding site 1 out of 3 in the The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 Dead-End Complex

Mono view

Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 Dead-End Complex within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Mn701 b:50.9 occ:1.00	OD1	A:ASP454	2.2	36.5	1.0
	OE1	A:GLU491	2.2	38.6	1.0
	O	A:ALA495	2.4	40.3	1.0
	CD	A:GLU491	3.0	41.0	1.0
	CG	A:ASP454	3.3	41.6	1.0
	OE2	A:GLU491	3.3	43.9	1.0
	C	A:ALA495	3.4	36.6	1.0
	OD2	A:ASP454	3.7	47.0	1.0
	O	A:THR323	3.9	45.7	1.0
	N	A:ALA495	4.1	32.8	1.0
	CG	A:GLU491	4.3	33.4	1.0
	CA	A:ALA495	4.3	34.6	1.0
	N	A:PHE496	4.3	37.4	1.0
	CA	A:PHE496	4.4	34.8	1.0
	CB	A:GLU491	4.4	35.2	1.0
	N	A:ALA455	4.6	32.3	1.0
	CB	A:ASP454	4.6	37.2	1.0
	O	A:ALA455	4.6	35.7	1.0
	CA	A:ASP454	4.7	37.9	1.0
	CB	A:ALA495	4.8	32.0	1.0

Manganese binding site 2 out of 3 in 1uvk

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Manganese Binding Sites List in 1uvk

Manganese binding site 2 out of 3 in the The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 Dead-End Complex

Mono view

Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 Dead-End Complex within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
C:Mn703 b:50.9 occ:1.00	OD1	C:ASP454	2.2	36.5	1.0
	OE1	C:GLU491	2.2	38.6	1.0
	O	C:ALA495	2.4	40.3	1.0
	CD	C:GLU491	3.0	41.0	1.0
	CG	C:ASP454	3.3	41.6	1.0
	OE2	C:GLU491	3.3	43.9	1.0
	C	C:ALA495	3.4	36.6	1.0
	OD2	C:ASP454	3.7	47.0	1.0
	O	C:THR323	3.9	45.7	1.0
	N	C:ALA495	4.1	32.8	1.0
	CG	C:GLU491	4.3	33.4	1.0
	CA	C:ALA495	4.3	34.6	1.0
	N	C:PHE496	4.3	37.4	1.0
	CA	C:PHE496	4.4	34.8	1.0
	CB	C:GLU491	4.4	35.2	1.0
	N	C:ALA455	4.6	32.3	1.0
	CB	C:ASP454	4.6	37.2	1.0
	O	C:ALA455	4.6	35.7	1.0
	CA	C:ASP454	4.7	37.9	1.0
	CB	C:ALA495	4.8	32.0	1.0

Manganese binding site 3 out of 3 in 1uvk

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Manganese Binding Sites List in 1uvk

Manganese binding site 3 out of 3 in the The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 Dead-End Complex

Mono view

Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 3 of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 Dead-End Complex within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
E:Mn703 b:50.9 occ:1.00	OD1	E:ASP454	2.2	36.5	1.0
	OE1	E:GLU491	2.2	38.6	1.0
	O	E:ALA495	2.4	40.3	1.0
	CD	E:GLU491	3.0	41.0	1.0
	CG	E:ASP454	3.3	41.6	1.0
	OE2	E:GLU491	3.3	43.9	1.0
	C	E:ALA495	3.4	36.6	1.0
	OD2	E:ASP454	3.7	47.0	1.0
	O	E:THR323	3.9	45.7	1.0
	N	E:ALA495	4.1	32.8	1.0
	CG	E:GLU491	4.3	33.4	1.0
	CA	E:ALA495	4.3	34.6	1.0
	N	E:PHE496	4.3	37.4	1.0
	CA	E:PHE496	4.4	34.8	1.0
	CB	E:GLU491	4.4	35.2	1.0
	N	E:ALA455	4.6	32.3	1.0
	CB	E:ASP454	4.6	37.2	1.0
	O	E:ALA455	4.6	35.7	1.0
	CA	E:ASP454	4.7	37.9	1.0
	CB	E:ALA495	4.8	32.0	1.0

Reference:

P.S.Salgado, E.V.Makeyev, S.J.Butcher, D.H.Bamford, D.I.Stuart, J.M.Grimes. The Structural Basis For Rna Specificity and CA2+ Inhibition of An Rna-Dependent Rna Polymerase. Structure V. 12 307 2004.
ISSN: ISSN 0969-2126
PubMed: 14962391
DOI: 10.1016/J.STR.2004.01.012

Page generated: Sat Oct 5 12:40:45 2024

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