Manganese in PDB 1uvj: The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 7NT Rna

Enzymatic activity of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 7NT Rna

All present enzymatic activity of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 7NT Rna:
2.7.7.48;

Protein crystallography data

The structure of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 7NT Rna, PDB code: 1uvj was solved by P.S.Salgado, E.V.Makeyev, S.Butcher, D.Bamford, D.I.Stuart, J.M.Grimes, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	18.74 / 1.90
*Space group*	P 1 2₁ 1
*Cell size a, b, c (Å), α, β, γ (°)*	105.062, 93.510, 140.711, 90.00, 101.19, 90.00
*R / R_free (%)*	24.2 / 27.1

Manganese Binding Sites:

The binding sites of Manganese atom in the The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 7NT Rna (pdb code 1uvj). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 3 binding sites of Manganese where determined in the The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 7NT Rna, PDB code: 1uvj:
Jump to Manganese binding site number: 1; 2; 3;

Manganese binding site 1 out of 3 in 1uvj

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Manganese Binding Sites List in 1uvj

Manganese binding site 1 out of 3 in the The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 7NT Rna

Mono view

Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 7NT Rna within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Mn1665 b:27.7 occ:1.00	OE1	A:GLU491	2.0	22.1	1.0
	OD1	A:ASP454	2.1	26.8	1.0
	O	A:HOH2179	2.2	26.3	1.0
	O	A:ALA495	2.2	29.4	1.0
	CD	A:GLU491	3.0	26.0	1.0
	CG	A:ASP454	3.1	30.8	1.0
	C	A:ALA495	3.3	28.6	1.0
	OE2	A:GLU491	3.5	30.4	1.0
	OD2	A:ASP454	3.5	26.4	1.0
	N	A:ALA495	3.9	28.0	1.0
	O	A:THR323	4.0	31.7	1.0
	CA	A:ALA495	4.1	26.4	1.0
	N	A:PHE496	4.2	26.9	1.0
	CA	A:PHE496	4.3	26.7	1.0
	CG	A:GLU491	4.3	29.5	1.0
	CB	A:ASP454	4.4	27.9	1.0
	CB	A:GLU491	4.5	31.4	1.0
	N	A:ALA455	4.5	27.1	1.0
	O	A:ALA455	4.5	26.1	1.0
	CB	A:ALA495	4.6	27.3	1.0
	CA	A:ASP454	4.6	26.8	1.0

Manganese binding site 2 out of 3 in 1uvj

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Manganese Binding Sites List in 1uvj

Manganese binding site 2 out of 3 in the The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 7NT Rna

Mono view

Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 7NT Rna within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
B:Mn1665 b:25.3 occ:1.00	OE1	B:GLU491	2.1	21.4	1.0
	OD1	B:ASP454	2.1	24.6	1.0
	O	B:HOH2271	2.2	28.0	1.0
	O	B:ALA495	2.2	23.4	1.0
	O	B:HOH2270	2.3	21.0	1.0
	O	B:HOH2269	2.4	22.1	1.0
	CD	B:GLU491	3.0	23.6	1.0
	CG	B:ASP454	3.1	25.2	1.0
	C	B:ALA495	3.3	27.5	1.0
	OE2	B:GLU491	3.5	23.9	1.0
	OD2	B:ASP454	3.5	21.0	1.0
	O	B:THR323	3.9	24.8	1.0
	N	B:ALA495	3.9	23.3	1.0
	CA	B:ALA495	4.1	27.0	1.0
	N	B:PHE496	4.2	23.9	1.0
	CG	B:GLU491	4.3	24.1	1.0
	CA	B:PHE496	4.3	27.9	1.0
	O	B:HOH2207	4.4	43.8	1.0
	CB	B:GLU491	4.4	21.5	1.0
	CB	B:ASP454	4.4	24.3	1.0
	N	B:ALA455	4.5	25.9	1.0
	O	B:ALA455	4.5	24.3	1.0
	CB	B:ALA495	4.6	26.5	1.0
	CA	B:ASP454	4.7	25.1	1.0
	O	B:HOH2228	4.7	39.0	1.0

Manganese binding site 3 out of 3 in 1uvj

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Manganese Binding Sites List in 1uvj

Manganese binding site 3 out of 3 in the The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 7NT Rna

Mono view

Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 3 of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 7NT Rna within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
C:Mn1665 b:30.5 occ:1.00	OE1	C:GLU491	2.0	25.0	1.0
	OD1	C:ASP454	2.2	29.7	1.0
	O	C:ALA495	2.2	28.8	1.0
	O	C:HOH2151	2.3	24.7	1.0
	O	C:HOH2150	2.3	34.1	1.0
	CD	C:GLU491	2.9	27.9	1.0
	CG	C:ASP454	3.1	28.2	1.0
	C	C:ALA495	3.4	28.8	1.0
	OE2	C:GLU491	3.4	27.9	1.0
	OD2	C:ASP454	3.5	26.8	1.0
	O	C:THR323	3.9	28.8	1.0
	N	C:ALA495	4.0	30.8	1.0
	CG	C:GLU491	4.2	23.0	1.0
	O	C:HOH2136	4.2	44.9	1.0
	CA	C:ALA495	4.2	29.6	1.0
	N	C:PHE496	4.3	27.4	1.0
	CA	C:PHE496	4.3	29.2	1.0
	CB	C:GLU491	4.4	24.6	1.0
	CB	C:ASP454	4.4	24.8	1.0
	N	C:ALA455	4.6	30.2	1.0
	O	C:ALA455	4.6	27.6	1.0
	CA	C:ASP454	4.7	27.0	1.0
	CB	C:ALA495	4.7	31.0	1.0
	OD1	C:ASP324	4.9	53.3	1.0

Reference:

P.S.Salgado, E.V.Makeyev, S.J.Butcher, D.H.Bamford, D.I.Stuart, J.M.Grimes. The Structural Basis For Rna Specificity and CA2+ Inhibition of An Rna-Dependent Rna Polymerase. Structure V. 12 307 2004.
ISSN: ISSN 0969-2126
PubMed: 14962391
DOI: 10.1016/J.STR.2004.01.012

Page generated: Sat Oct 5 12:40:45 2024

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