Manganese in PDB 1uvi: The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 6NT Rna

Enzymatic activity of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 6NT Rna

All present enzymatic activity of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 6NT Rna:
2.7.7.48;

Protein crystallography data

The structure of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 6NT Rna, PDB code: 1uvi was solved by P.S.Salgado, E.V.Makeyev, S.Butcher, D.Bamford, D.I.Stuart, J.M.Grimes, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	19.93 / 2.15
*Space group*	P 1 2₁ 1
*Cell size a, b, c (Å), α, β, γ (°)*	105.130, 93.711, 140.741, 90.00, 101.22, 90.00
*R / R_free (%)*	23 / 25.6

Manganese Binding Sites:

The binding sites of Manganese atom in the The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 6NT Rna (pdb code 1uvi). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 3 binding sites of Manganese where determined in the The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 6NT Rna, PDB code: 1uvi:
Jump to Manganese binding site number: 1; 2; 3;

Manganese binding site 1 out of 3 in 1uvi

Go back to

Manganese Binding Sites List in 1uvi

Manganese binding site 1 out of 3 in the The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 6NT Rna

Mono view

Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 6NT Rna within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Mn1665 b:29.2 occ:1.00	OE1	A:GLU491	2.1	22.2	1.0
	OD1	A:ASP454	2.1	24.7	1.0
	O	A:ALA495	2.1	30.4	1.0
	CD	A:GLU491	3.1	24.2	1.0
	CG	A:ASP454	3.1	31.6	1.0
	C	A:ALA495	3.2	28.6	1.0
	OE2	A:GLU491	3.5	28.2	1.0
	OD2	A:ASP454	3.5	28.6	1.0
	O	A:THR323	3.9	37.4	1.0
	N	A:ALA495	4.0	26.9	1.0
	CA	A:ALA495	4.1	25.5	1.0
	N	A:PHE496	4.1	27.8	1.0
	CA	A:PHE496	4.2	25.0	1.0
	CG	A:GLU491	4.4	28.3	1.0
	CB	A:ASP454	4.4	26.8	1.0
	N	A:ALA455	4.4	24.1	1.0
	O	A:ALA455	4.5	26.2	1.0
	CB	A:GLU491	4.5	31.3	1.0
	CB	A:ALA495	4.6	31.7	1.0
	CA	A:ASP454	4.6	27.9	1.0

Manganese binding site 2 out of 3 in 1uvi

Go back to

Manganese Binding Sites List in 1uvi

Manganese binding site 2 out of 3 in the The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 6NT Rna

Mono view

Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 6NT Rna within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
B:Mn1665 b:26.4 occ:1.00	OE1	B:GLU491	2.0	19.4	1.0
	OD1	B:ASP454	2.1	21.2	1.0
	O	B:HOH2192	2.2	28.4	1.0
	O	B:ALA495	2.2	17.4	1.0
	O	B:HOH2191	2.4	19.6	1.0
	CD	B:GLU491	3.0	23.3	1.0
	CG	B:ASP454	3.1	28.7	1.0
	C	B:ALA495	3.2	23.3	1.0
	OE2	B:GLU491	3.4	26.6	1.0
	OD2	B:ASP454	3.5	22.8	1.0
	N	B:ALA495	3.8	22.7	1.0
	O	B:THR323	4.0	32.1	1.0
	CA	B:ALA495	4.0	23.0	1.0
	N	B:PHE496	4.2	23.2	1.0
	CG	B:GLU491	4.2	24.2	1.0
	O	B:HOH2055	4.3	36.7	1.0
	CA	B:PHE496	4.3	27.4	1.0
	CB	B:GLU491	4.4	26.9	1.0
	CB	B:ASP454	4.4	23.0	1.0
	CB	B:ALA495	4.5	29.4	1.0
	N	B:ALA455	4.6	24.0	1.0
	O	B:ALA455	4.6	27.0	1.0
	CA	B:ASP454	4.7	26.6	1.0

Manganese binding site 3 out of 3 in 1uvi

Go back to

Manganese Binding Sites List in 1uvi

Manganese binding site 3 out of 3 in the The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 6NT Rna

Mono view

Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 3 of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 6NT Rna within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
C:Mn1665 b:30.8 occ:1.00	OE1	C:GLU491	2.0	26.8	1.0
	OD1	C:ASP454	2.1	23.2	1.0
	O	C:ALA495	2.2	25.4	1.0
	O	C:HOH2109	2.3	19.7	1.0
	CD	C:GLU491	2.9	30.9	1.0
	CG	C:ASP454	3.1	28.3	1.0
	OE2	C:GLU491	3.3	28.5	1.0
	C	C:ALA495	3.3	28.2	1.0
	OD2	C:ASP454	3.5	28.1	1.0
	O	C:THR323	3.9	32.0	1.0
	N	C:ALA495	4.0	25.2	1.0
	CA	C:ALA495	4.2	25.8	1.0
	CG	C:GLU491	4.2	27.7	1.0
	N	C:PHE496	4.3	27.1	1.0
	O	C:HOH2099	4.3	34.5	1.0
	CB	C:ASP454	4.4	24.9	1.0
	CA	C:PHE496	4.4	26.5	1.0
	CB	C:GLU491	4.4	26.1	1.0
	N	C:ALA455	4.5	30.3	1.0
	O	C:ALA455	4.6	26.9	1.0
	CA	C:ASP454	4.6	25.1	1.0
	CB	C:ALA495	4.7	32.4	1.0

Reference:

P.S.Salgado, E.V.Makeyev, S.J.Butcher, D.H.Bamford, D.I.Stuart, J.M.Grimes. The Structural Basis For Rna Specificity and CA2+ Inhibition of An Rna-Dependent Rna Polymerase. Structure V. 12 307 2004.
ISSN: ISSN 0969-2126
PubMed: 14962391
DOI: 10.1016/J.STR.2004.01.012

Page generated: Sat Oct 5 12:39:25 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0

	© Copyright 2008-2020 by atomistry.com
Home \| Site Map \| Copyright \| Contact us \| Privacy