Manganese in PDB 1uvi: The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 6NT Rna

Enzymatic activity of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 6NT Rna

All present enzymatic activity of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 6NT Rna:
2.7.7.48;

Protein crystallography data

The structure of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 6NT Rna, PDB code: 1uvi was solved by P.S.Salgado, E.V.Makeyev, S.Butcher, D.Bamford, D.I.Stuart, J.M.Grimes, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	19.93 / 2.15
*Space group*	P 1 2₁ 1
*Cell size a, b, c (Å), α, β, γ (°)*	105.130, 93.711, 140.741, 90.00, 101.22, 90.00
*R / R_free (%)*	23 / 25.6

Manganese Binding Sites:

The binding sites of Manganese atom in the The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 6NT Rna (pdb code 1uvi). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 3 binding sites of Manganese where determined in the The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 6NT Rna, PDB code: 1uvi:
Jump to Manganese binding site number: 1; 2; 3;

Manganese binding site 1 out of 3 in 1uvi

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Manganese Binding Sites List in 1uvi

Manganese binding site 1 out of 3 in the The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 6NT Rna

Mono view

Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 6NT Rna within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Mn1665 b:29.2 occ:1.00	OE1	A:GLU491	2.1	22.2	1.0
	OD1	A:ASP454	2.1	24.7	1.0
	O	A:ALA495	2.1	30.4	1.0
	CD	A:GLU491	3.1	24.2	1.0
	CG	A:ASP454	3.1	31.6	1.0
	C	A:ALA495	3.2	28.6	1.0
	OE2	A:GLU491	3.5	28.2	1.0
	OD2	A:ASP454	3.5	28.6	1.0
	O	A:THR323	3.9	37.4	1.0
	N	A:ALA495	4.0	26.9	1.0
	CA	A:ALA495	4.1	25.5	1.0
	N	A:PHE496	4.1	27.8	1.0
	CA	A:PHE496	4.2	25.0	1.0
	CG	A:GLU491	4.4	28.3	1.0
	CB	A:ASP454	4.4	26.8	1.0
	N	A:ALA455	4.4	24.1	1.0
	O	A:ALA455	4.5	26.2	1.0
	CB	A:GLU491	4.5	31.3	1.0
	CB	A:ALA495	4.6	31.7	1.0
	CA	A:ASP454	4.6	27.9	1.0

Manganese binding site 2 out of 3 in 1uvi

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Manganese Binding Sites List in 1uvi

Manganese binding site 2 out of 3 in the The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 6NT Rna

Mono view

Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 6NT Rna within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
B:Mn1665 b:26.4 occ:1.00	OE1	B:GLU491	2.0	19.4	1.0
	OD1	B:ASP454	2.1	21.2	1.0
	O	B:HOH2192	2.2	28.4	1.0
	O	B:ALA495	2.2	17.4	1.0
	O	B:HOH2191	2.4	19.6	1.0
	CD	B:GLU491	3.0	23.3	1.0
	CG	B:ASP454	3.1	28.7	1.0
	C	B:ALA495	3.2	23.3	1.0
	OE2	B:GLU491	3.4	26.6	1.0
	OD2	B:ASP454	3.5	22.8	1.0
	N	B:ALA495	3.8	22.7	1.0
	O	B:THR323	4.0	32.1	1.0
	CA	B:ALA495	4.0	23.0	1.0
	N	B:PHE496	4.2	23.2	1.0
	CG	B:GLU491	4.2	24.2	1.0
	O	B:HOH2055	4.3	36.7	1.0
	CA	B:PHE496	4.3	27.4	1.0
	CB	B:GLU491	4.4	26.9	1.0
	CB	B:ASP454	4.4	23.0	1.0
	CB	B:ALA495	4.5	29.4	1.0
	N	B:ALA455	4.6	24.0	1.0
	O	B:ALA455	4.6	27.0	1.0
	CA	B:ASP454	4.7	26.6	1.0

Manganese binding site 3 out of 3 in 1uvi

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Manganese Binding Sites List in 1uvi

Manganese binding site 3 out of 3 in the The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 6NT Rna

Mono view

Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 3 of The Structural Basis For Rna Specificity and CA2 Inhibition of An Rna- Dependent Rna Polymerase PHI6P2 with 6NT Rna within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
C:Mn1665 b:30.8 occ:1.00	OE1	C:GLU491	2.0	26.8	1.0
	OD1	C:ASP454	2.1	23.2	1.0
	O	C:ALA495	2.2	25.4	1.0
	O	C:HOH2109	2.3	19.7	1.0
	CD	C:GLU491	2.9	30.9	1.0
	CG	C:ASP454	3.1	28.3	1.0
	OE2	C:GLU491	3.3	28.5	1.0
	C	C:ALA495	3.3	28.2	1.0
	OD2	C:ASP454	3.5	28.1	1.0
	O	C:THR323	3.9	32.0	1.0
	N	C:ALA495	4.0	25.2	1.0
	CA	C:ALA495	4.2	25.8	1.0
	CG	C:GLU491	4.2	27.7	1.0
	N	C:PHE496	4.3	27.1	1.0
	O	C:HOH2099	4.3	34.5	1.0
	CB	C:ASP454	4.4	24.9	1.0
	CA	C:PHE496	4.4	26.5	1.0
	CB	C:GLU491	4.4	26.1	1.0
	N	C:ALA455	4.5	30.3	1.0
	O	C:ALA455	4.6	26.9	1.0
	CA	C:ASP454	4.6	25.1	1.0
	CB	C:ALA495	4.7	32.4	1.0

Reference:

P.S.Salgado, E.V.Makeyev, S.J.Butcher, D.H.Bamford, D.I.Stuart, J.M.Grimes. The Structural Basis For Rna Specificity and CA2+ Inhibition of An Rna-Dependent Rna Polymerase. Structure V. 12 307 2004.
ISSN: ISSN 0969-2126
PubMed: 14962391
DOI: 10.1016/J.STR.2004.01.012

Page generated: Sat Oct 5 12:39:25 2024

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