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Manganese in PDB 1rx3: Dihydrofolate Reductase (E.C.1.5.1.3) Complexed with Methotrexate and Nicotinamide Adenine Dinucleotide Phosphate (Reduced Form)
Enzymatic activity of Dihydrofolate Reductase (E.C.1.5.1.3) Complexed with Methotrexate and Nicotinamide Adenine Dinucleotide Phosphate (Reduced Form)
All present enzymatic activity of Dihydrofolate Reductase (E.C.1.5.1.3) Complexed with Methotrexate and Nicotinamide Adenine Dinucleotide Phosphate (Reduced Form):
1.5.1.3;
1.5.1.3;
Protein crystallography data
The structure of Dihydrofolate Reductase (E.C.1.5.1.3) Complexed with Methotrexate and Nicotinamide Adenine Dinucleotide Phosphate (Reduced Form), PDB code: 1rx3
was solved by
M.R.Sawaya,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 20.00 / 2.20 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 34.360, 45.511, 98.691, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 15.6 / n/a |
Manganese Binding Sites:
The binding sites of Manganese atom in the Dihydrofolate Reductase (E.C.1.5.1.3) Complexed with Methotrexate and Nicotinamide Adenine Dinucleotide Phosphate (Reduced Form)
(pdb code 1rx3). This binding sites where shown within
5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Dihydrofolate Reductase (E.C.1.5.1.3) Complexed with Methotrexate and Nicotinamide Adenine Dinucleotide Phosphate (Reduced Form), PDB code: 1rx3:
In total only one binding site of Manganese was determined in the Dihydrofolate Reductase (E.C.1.5.1.3) Complexed with Methotrexate and Nicotinamide Adenine Dinucleotide Phosphate (Reduced Form), PDB code: 1rx3:
Manganese binding site 1 out of 1 in 1rx3
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Manganese Binding Sites List in 1rx3
Manganese binding site 1 out
of 1 in the Dihydrofolate Reductase (E.C.1.5.1.3) Complexed with Methotrexate and Nicotinamide Adenine Dinucleotide Phosphate (Reduced Form)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 1 of Dihydrofolate Reductase (E.C.1.5.1.3) Complexed with Methotrexate and Nicotinamide Adenine Dinucleotide Phosphate (Reduced Form) within 5.0Å range:
|
Reference:
M.R.Sawaya,
J.Kraut.
Loop and Subdomain Movements in the Mechanism of Escherichia Coli Dihydrofolate Reductase: Crystallographic Evidence. Biochemistry V. 36 586 1997.
ISSN: ISSN 0006-2960
PubMed: 9012674
DOI: 10.1021/BI962337C
Page generated: Sat Oct 5 12:21:21 2024
ISSN: ISSN 0006-2960
PubMed: 9012674
DOI: 10.1021/BI962337C
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