Manganese in PDB 1r9c: Crystal Structure of Fosfomycin Resistance Protein Fosx From Mesorhizobium Loti

All present enzymatic activity of Crystal Structure of Fosfomycin Resistance Protein Fosx From Mesorhizobium Loti:
2.5.1.1;

The structure of Crystal Structure of Fosfomycin Resistance Protein Fosx From Mesorhizobium Loti, PDB code: 1r9c was solved by K.L.Fillgrove, S.Pakhomova, M.E.Newcomer, R.N.Armstrong, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 1.83
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	45.034, 84.024, 66.861, 90.00, 90.00, 90.00
R / Rfree (%)	20.2 / 24.3

The binding sites of Manganese atom in the Crystal Structure of Fosfomycin Resistance Protein Fosx From Mesorhizobium Loti (pdb code 1r9c). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the Crystal Structure of Fosfomycin Resistance Protein Fosx From Mesorhizobium Loti, PDB code: 1r9c:
Jump to Manganese binding site number: 1; 2;

Manganese binding site 1 out of 2 in the Crystal Structure of Fosfomycin Resistance Protein Fosx From Mesorhizobium Loti


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Crystal Structure of Fosfomycin Resistance Protein Fosx From Mesorhizobium Loti within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn2001 b:29.5 occ:1.00 OE1 A:GLU118 1.9 22.7 1.0 NE2 B:HIS7 2.1 20.2 1.0 NE2 A:HIS69 2.1 20.5 1.0 O B:HOH1002 2.2 34.7 1.0 O A:HOH2054 2.6 39.2 1.0 CE1 A:HIS69 3.0 18.8 1.0 O A:HOH2058 3.0 47.3 1.0 CE1 B:HIS7 3.0 19.4 1.0 CD A:GLU118 3.0 21.4 1.0 CD2 B:HIS7 3.1 19.5 1.0 CD2 A:HIS69 3.1 19.7 1.0 OE2 A:GLU118 3.5 18.6 1.0 OG1 B:THR9 3.8 22.8 1.0 OH A:TYR108 4.0 31.6 1.0 CE2 A:TYR108 4.1 27.4 1.0 ND1 A:HIS69 4.1 21.3 1.0 ND1 B:HIS7 4.1 21.2 1.0 CG B:HIS7 4.2 18.7 1.0 CG A:HIS69 4.2 21.4 1.0 CG A:GLU118 4.4 20.6 1.0 O B:HOH1026 4.4 39.2 1.0 CZ A:TYR108 4.5 26.4 1.0 CB A:ALA71 4.5 21.3 1.0 CB A:GLU118 4.7 20.5 1.0 CB B:THR9 4.8 21.0 1.0

Manganese binding site 2 out of 2 in the Crystal Structure of Fosfomycin Resistance Protein Fosx From Mesorhizobium Loti


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Crystal Structure of Fosfomycin Resistance Protein Fosx From Mesorhizobium Loti within 5.0Å range: probe atom residue distance (Å) B Occ B:Mn1001 b:28.9 occ:1.00 OE1 B:GLU118 1.9 20.4 1.0 NE2 B:HIS69 2.1 19.9 1.0 NE2 A:HIS7 2.1 18.6 1.0 O A:HOH2002 2.3 35.4 1.0 O B:HOH1017 2.4 33.5 1.0 O B:HOH1035 2.5 50.8 1.0 CE1 B:HIS69 3.0 20.6 1.0 CD B:GLU118 3.0 22.3 1.0 CE1 A:HIS7 3.0 20.2 1.0 CD2 B:HIS69 3.1 18.8 1.0 CD2 A:HIS7 3.1 19.1 1.0 OE2 B:GLU118 3.3 24.4 1.0 OG1 A:THR9 4.0 25.0 1.0 ND1 B:HIS69 4.1 20.0 1.0 ND1 A:HIS7 4.1 20.1 1.0 CG B:HIS69 4.2 21.0 1.0 OH B:TYR108 4.2 31.1 1.0 CG A:HIS7 4.2 20.4 1.0 CE2 B:TYR108 4.3 28.7 1.0 CG B:GLU118 4.4 23.0 1.0 CB B:ALA71 4.6 21.5 1.0 CZ B:TYR108 4.7 29.9 1.0 CB B:GLU118 4.8 21.1 1.0 CB A:THR9 4.9 21.8 1.0

K.L.Fillgrove, S.Pakhomova, M.E.Newcomer, R.N.Armstrong. Mechanistic Diversity of Fosfomycin Resistance in Pathogenic Microorganisms. J.Am.Chem.Soc. V. 125 15730 2003.
ISSN: ISSN 0002-7863
PubMed: 14677948
DOI: 10.1021/JA039307Z