Manganese in PDB 1r80: Glycosyltransferase B in Complex with 3-Amino-Acceptor Analog Inhibitor and Uridine Diphosphate

Enzymatic activity of Glycosyltransferase B in Complex with 3-Amino-Acceptor Analog Inhibitor and Uridine Diphosphate

All present enzymatic activity of Glycosyltransferase B in Complex with 3-Amino-Acceptor Analog Inhibitor and Uridine Diphosphate:
2.4.1.37;

Protein crystallography data

The structure of Glycosyltransferase B in Complex with 3-Amino-Acceptor Analog Inhibitor and Uridine Diphosphate, PDB code: 1r80 was solved by H.P.Nguyen, N.O.L.Seto, Y.Cai, E.K.Leinala, S.N.Borisova, M.M.Palcic, S.V.Evans, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	49.65 / 1.65
*Space group*	C 2 2 2₁
*Cell size a, b, c (Å), α, β, γ (°)*	52.600, 150.500, 79.300, 90.00, 90.00, 90.00
*R / R_free (%)*	20.9 / 22.8

Other elements in 1r80:

The structure of Glycosyltransferase B in Complex with 3-Amino-Acceptor Analog Inhibitor and Uridine Diphosphate also contains other interesting chemical elements:

Mercury

(Hg)

3 atoms

Manganese Binding Sites:

The binding sites of Manganese atom in the Glycosyltransferase B in Complex with 3-Amino-Acceptor Analog Inhibitor and Uridine Diphosphate (pdb code 1r80). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Glycosyltransferase B in Complex with 3-Amino-Acceptor Analog Inhibitor and Uridine Diphosphate, PDB code: 1r80:

Manganese binding site 1 out of 1 in 1r80

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Manganese Binding Sites List in 1r80

Manganese binding site 1 out of 1 in the Glycosyltransferase B in Complex with 3-Amino-Acceptor Analog Inhibitor and Uridine Diphosphate

Mono view

Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Glycosyltransferase B in Complex with 3-Amino-Acceptor Analog Inhibitor and Uridine Diphosphate within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Mn406 b:45.0 occ:1.00	O3B	A:UDP475	2.3	47.4	1.0
	OD2	A:ASP213	2.5	22.7	1.0
	O1A	A:UDP475	2.7	47.0	1.0
	OD1	A:ASP213	2.8	26.4	1.0
	OD2	A:ASP211	2.8	22.0	1.0
	CG	A:ASP213	3.0	21.7	1.0
	PB	A:UDP475	3.2	46.7	1.0
	O3A	A:UDP475	3.5	46.4	1.0
	CG	A:ASP211	3.5	17.9	1.0
	CB	A:ASP211	3.6	16.3	1.0
	PA	A:UDP475	3.7	45.6	1.0
	O2B	A:UDP475	3.7	47.4	1.0
	O3'	A:UDP475	3.7	39.1	1.0
	C5'	A:UDP475	4.2	41.6	1.0
	O5'	A:UDP475	4.3	44.1	1.0
	C3'	A:UDP475	4.4	39.9	1.0
	CB	A:ASP213	4.5	19.1	1.0
	O1B	A:UDP475	4.6	46.9	1.0
	OD1	A:ASP211	4.6	19.3	1.0
	C4'	A:UDP475	4.8	40.7	1.0
	O	A:ASP213	4.8	15.0	1.0
	SD	A:MET214	5.0	19.2	1.0

Reference:

H.P.Nguyen, N.O.L.Seto, Y.Cai, E.K.Leinala, S.N.Borisova, M.M.Palcic, S.V.Evans. The Influence of An Intramolecular Hydrogen Bond in Differential Recognition of Inhibitory Acceptor Analogs By Human Abo(H) Blood Group A and B Glycosyltransferases J.Biol.Chem. V. 278 49191 2003.
ISSN: ISSN 0021-9258
PubMed: 12972418
DOI: 10.1074/JBC.M308770200

Page generated: Sat Oct 5 12:18:29 2024

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