Manganese in PDB 1r7y: Glycosyltransferase A in Complex with 3-Amino-Acceptor Analog Inhibitor and Uridine Diphosphate

Enzymatic activity of Glycosyltransferase A in Complex with 3-Amino-Acceptor Analog Inhibitor and Uridine Diphosphate

All present enzymatic activity of Glycosyltransferase A in Complex with 3-Amino-Acceptor Analog Inhibitor and Uridine Diphosphate:
2.4.1.40;

Protein crystallography data

The structure of Glycosyltransferase A in Complex with 3-Amino-Acceptor Analog Inhibitor and Uridine Diphosphate, PDB code: 1r7y was solved by H.P.Nguyen, N.O.L.Seto, Y.Cai, E.K.Leinala, S.N.Borisova, M.M.Palcic, S.V.Evans, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	36.13 / 1.75
*Space group*	C 2 2 2₁
*Cell size a, b, c (Å), α, β, γ (°)*	52.500, 149.400, 79.400, 90.00, 90.00, 90.00
*R / R_free (%)*	20.8 / 21.6

Other elements in 1r7y:

The structure of Glycosyltransferase A in Complex with 3-Amino-Acceptor Analog Inhibitor and Uridine Diphosphate also contains other interesting chemical elements:

Mercury

(Hg)

5 atoms

Manganese Binding Sites:

The binding sites of Manganese atom in the Glycosyltransferase A in Complex with 3-Amino-Acceptor Analog Inhibitor and Uridine Diphosphate (pdb code 1r7y). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Glycosyltransferase A in Complex with 3-Amino-Acceptor Analog Inhibitor and Uridine Diphosphate, PDB code: 1r7y:

Manganese binding site 1 out of 1 in 1r7y

Go back to

Manganese Binding Sites List in 1r7y

Manganese binding site 1 out of 1 in the Glycosyltransferase A in Complex with 3-Amino-Acceptor Analog Inhibitor and Uridine Diphosphate

Mono view

Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Glycosyltransferase A in Complex with 3-Amino-Acceptor Analog Inhibitor and Uridine Diphosphate within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Mn406 b:50.4 occ:0.50	O3B	A:UDP475	2.3	55.3	1.0
	OD2	A:ASP213	2.5	21.9	1.0
	O1A	A:UDP475	2.7	56.8	1.0
	OD1	A:ASP213	2.9	26.5	1.0
	CG	A:ASP213	3.1	23.6	1.0
	PB	A:UDP475	3.2	57.0	1.0
	OD2	A:ASP211	3.2	24.3	1.0
	O3'	A:UDP475	3.3	47.7	1.0
	O3A	A:UDP475	3.5	55.8	1.0
	CG	A:ASP211	3.5	20.8	1.0
	PA	A:UDP475	3.6	56.0	1.0
	CB	A:ASP211	3.6	20.0	1.0
	C5'	A:UDP475	3.7	50.1	1.0
	O2B	A:UDP475	3.8	56.8	1.0
	CE	A:MET214	3.9	23.7	1.0
	C3'	A:UDP475	3.9	47.6	1.0
	O5'	A:UDP475	4.0	53.5	1.0
	C4'	A:UDP475	4.3	48.2	1.0
	OD1	A:ASP211	4.4	21.4	1.0
	CB	A:ASP213	4.6	21.8	1.0
	O1B	A:UDP475	4.6	56.0	1.0
	O	A:ASP213	5.0	18.6	1.0
	CA	A:ASP211	5.0	18.6	1.0
	O2A	A:UDP475	5.0	56.7	1.0
	N	A:ASP213	5.0	18.8	1.0

Reference:

H.P.Nguyen, N.O.L.Seto, Y.Cai, E.K.Leinala, S.N.Borisova, M.M.Palcic, S.V.Evans. The Influence of An Intramolecular Hydrogen Bond in Differential Recognition of Inhibitory Acceptor Analogs By Human Abo(H) Blood Group A and B Glycosyltransferases J.Biol.Chem. V. 278 49191 2003.
ISSN: ISSN 0021-9258
PubMed: 12972418
DOI: 10.1074/JBC.M308770200

Page generated: Sat Oct 5 12:18:29 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW

	© Copyright 2008-2020 by atomistry.com
Home \| Site Map \| Copyright \| Contact us \| Privacy