Manganese in PDB 1omz: Crystal Structure of Mouse Alpha-1,4-N-Acetylhexosaminyltransferase (EXTL2) in Complex with Udpgalnac

The structure of Crystal Structure of Mouse Alpha-1,4-N-Acetylhexosaminyltransferase (EXTL2) in Complex with Udpgalnac, PDB code: 1omz was solved by L.C.Pedersen, J.Dong, F.Taniguchi, H.Kitagawa, J.M.Krahn, L.G.Pedersen, K.Sugahara, M.Negishi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.88 / 2.10
Space group	P 4 21 2
Cell size a, b, c (Å), α, β, γ (°)	126.339, 126.339, 83.929, 90.00, 90.00, 90.00
R / Rfree (%)	20.1 / 23.3

The binding sites of Manganese atom in the Crystal Structure of Mouse Alpha-1,4-N-Acetylhexosaminyltransferase (EXTL2) in Complex with Udpgalnac (pdb code 1omz). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the Crystal Structure of Mouse Alpha-1,4-N-Acetylhexosaminyltransferase (EXTL2) in Complex with Udpgalnac, PDB code: 1omz:
Jump to Manganese binding site number: 1; 2;

Manganese binding site 1 out of 2 in the Crystal Structure of Mouse Alpha-1,4-N-Acetylhexosaminyltransferase (EXTL2) in Complex with Udpgalnac


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Crystal Structure of Mouse Alpha-1,4-N-Acetylhexosaminyltransferase (EXTL2) in Complex with Udpgalnac within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn600 b:54.5 occ:1.00 O1A A:UD2405 2.1 46.0 1.0 O A:HOH706 2.2 33.9 1.0 O A:HOH603 2.2 39.7 1.0 O A:HOH601 2.3 25.3 1.0 OD2 A:ASP153 2.3 29.1 1.0 O1B A:UD2405 2.5 47.8 1.0 CG A:ASP153 3.2 27.0 1.0 PA A:UD2405 3.3 44.3 1.0 OD1 A:ASP153 3.4 25.6 1.0 PB A:UD2405 3.6 48.3 1.0 O3A A:UD2405 3.7 47.9 1.0 O1' A:UD2405 3.9 51.0 1.0 O2A A:UD2405 4.0 44.1 1.0 NH2 A:ARG76 4.0 30.8 1.0 ND2 A:ASN272 4.1 36.2 1.0 NH1 A:ARG76 4.2 30.3 1.0 OE2 A:GLU274 4.3 61.8 1.0 OD2 A:ASP151 4.6 24.9 1.0 CB A:ASP153 4.6 27.6 1.0 O5B A:UD2405 4.6 43.6 1.0 CZ A:ARG76 4.6 33.4 1.0 C5B A:UD2405 4.9 41.6 1.0 O2B A:UD2405 5.0 50.5 1.0

Manganese binding site 2 out of 2 in the Crystal Structure of Mouse Alpha-1,4-N-Acetylhexosaminyltransferase (EXTL2) in Complex with Udpgalnac


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Crystal Structure of Mouse Alpha-1,4-N-Acetylhexosaminyltransferase (EXTL2) in Complex with Udpgalnac within 5.0Å range: probe atom residue distance (Å) B Occ B:Mn601 b:45.9 occ:1.00 OD2 B:ASP153 2.1 25.4 1.0 O1A B:UD2404 2.1 40.3 1.0 O B:HOH602 2.2 33.4 1.0 O B:HOH603 2.2 25.5 1.0 O B:HOH604 2.2 50.0 1.0 O1B B:UD2404 2.4 39.1 1.0 CG B:ASP153 3.2 25.4 1.0 PA B:UD2404 3.4 38.1 1.0 PB B:UD2404 3.5 38.7 1.0 OD1 B:ASP153 3.5 25.9 1.0 O3A B:UD2404 3.6 39.6 1.0 O1' B:UD2404 3.9 41.0 1.0 ND2 B:ASN272 4.0 37.0 1.0 O2A B:UD2404 4.1 37.3 1.0 NH2 B:ARG76 4.1 28.1 1.0 NH1 B:ARG76 4.3 28.7 1.0 CB B:ASP153 4.5 25.3 1.0 OD2 B:ASP151 4.6 27.7 1.0 O5B B:UD2404 4.6 37.3 1.0 CZ B:ARG76 4.7 29.8 1.0 O2B B:UD2404 4.9 40.6 1.0 C5B B:UD2404 4.9 34.4 1.0

L.C.Pedersen, J.Dong, F.Taniguchi, H.Kitagawa, J.M.Krahn, L.G.Pedersen, K.Sugahara, M.Negishi. Crystal Structure of An Alpha-1,4-N-Acetylhexosaminyltransferase (EXTL2), A Member of the Exostosin Gene Family Involved in Heparan Sulfate Biosynthesis J.Biol.Chem. V. 278 14420 2003.
ISSN: ISSN 0021-9258
PubMed: 12562774
DOI: 10.1074/JBC.M210532200