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Manganese in PDB 1ofb: Crystal Structure of the Tyrosine-Regulated 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate Synthase From Saccharomyces Cerevisiae in Complex with Manganese(II)

Enzymatic activity of Crystal Structure of the Tyrosine-Regulated 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate Synthase From Saccharomyces Cerevisiae in Complex with Manganese(II)

All present enzymatic activity of Crystal Structure of the Tyrosine-Regulated 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate Synthase From Saccharomyces Cerevisiae in Complex with Manganese(II):
4.1.2.15;

Protein crystallography data

The structure of Crystal Structure of the Tyrosine-Regulated 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate Synthase From Saccharomyces Cerevisiae in Complex with Manganese(II), PDB code: 1ofb was solved by V.Koenig, A.Pfeil, G.Heinrich, G.H.Braus, T.R.Schneider, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.92 / 2.0
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 196.636, 50.502, 64.930, 90.00, 106.36, 90.00
R / Rfree (%) 16.1 / 20.7

Manganese Binding Sites:

The binding sites of Manganese atom in the Crystal Structure of the Tyrosine-Regulated 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate Synthase From Saccharomyces Cerevisiae in Complex with Manganese(II) (pdb code 1ofb). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the Crystal Structure of the Tyrosine-Regulated 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate Synthase From Saccharomyces Cerevisiae in Complex with Manganese(II), PDB code: 1ofb:
Jump to Manganese binding site number: 1; 2;

Manganese binding site 1 out of 2 in 1ofb

Go back to Manganese Binding Sites List in 1ofb
Manganese binding site 1 out of 2 in the Crystal Structure of the Tyrosine-Regulated 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate Synthase From Saccharomyces Cerevisiae in Complex with Manganese(II)


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Crystal Structure of the Tyrosine-Regulated 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate Synthase From Saccharomyces Cerevisiae in Complex with Manganese(II) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn400

b:31.4
occ:1.00
 OE2 A:GLU316 1.9 32.6 1.0
OD1 A:ASP342 2.1 33.1 1.0
NE2 A:HIS282 2.3 27.4 1.0
SG A:CYS76 2.7 28.3 1.0
CD A:GLU316 2.9 30.1 1.0
CG A:ASP342 3.1 30.8 1.0
OE1 A:GLU316 3.2 32.6 1.0
CE1 A:HIS282 3.2 29.3 1.0
CD2 A:HIS282 3.3 28.9 1.0
O A:HOH2018 3.3 35.5 1.0
CB A:ASP342 3.5 30.2 1.0
CB A:CYS76 3.8 27.5 1.0
NZ A:LYS112 4.0 25.1 1.0
OD2 A:ASP342 4.0 28.0 1.0
CG A:GLU316 4.2 28.5 1.0
NH2 A:ARG107 4.2 29.9 1.0
O A:HOH2088 4.3 31.8 1.0
CA A:CYS76 4.3 29.3 1.0
ND1 A:HIS282 4.3 28.2 1.0
CG A:HIS282 4.4 28.6 1.0
CA A:ASP342 4.8 31.2 1.0
CE A:LYS112 4.9 32.0 1.0
O A:CYS76 4.9 28.2 1.0
N A:ASP342 4.9 30.3 1.0
C A:CYS76 5.0 28.8 1.0

Manganese binding site 2 out of 2 in 1ofb

Go back to Manganese Binding Sites List in 1ofb
Manganese binding site 2 out of 2 in the Crystal Structure of the Tyrosine-Regulated 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate Synthase From Saccharomyces Cerevisiae in Complex with Manganese(II)


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Crystal Structure of the Tyrosine-Regulated 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate Synthase From Saccharomyces Cerevisiae in Complex with Manganese(II) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mn400

b:29.8
occ:1.00
 OE2 B:GLU316 2.1 28.6 1.0
OD1 B:ASP342 2.2 23.5 1.0
NE2 B:HIS282 2.3 28.7 1.0
SG B:CYS76 2.7 26.2 1.0
CD B:GLU316 2.9 25.6 1.0
OE1 B:GLU316 3.1 25.0 1.0
CG B:ASP342 3.2 29.4 1.0
CD2 B:HIS282 3.2 31.9 1.0
CE1 B:HIS282 3.3 28.5 1.0
O B:HOH2025 3.3 34.1 1.0
CB B:CYS76 3.6 25.5 1.0
CB B:ASP342 3.6 27.9 1.0
NZ B:LYS112 3.9 23.1 1.0
OD2 B:ASP342 4.2 29.0 1.0
NH2 B:ARG107 4.2 26.0 1.0
CA B:CYS76 4.2 25.1 1.0
CG B:GLU316 4.3 27.8 1.0
ND1 B:HIS282 4.4 27.4 1.0
O B:HOH2101 4.4 30.2 1.0
CG B:HIS282 4.4 27.3 1.0
CE B:LYS112 4.8 26.6 1.0
O B:CYS76 4.9 23.9 1.0
CA B:ASP342 4.9 29.1 1.0
N B:ASP342 4.9 27.8 1.0
C B:CYS76 5.0 26.7 1.0
CZ B:ARG107 5.0 29.7 1.0

Reference:

V.Koenig, A.Pfeil, G.H.Braus, T.R.Schneider. Substrate and Metal Complexes of 3-Deoxy-D- Arabino-Heptulosonate-7-Phosphate Synthase From Saccharomyces Cerevisiae Provide New Insights Into the Catalytic Mechanism J.Mol.Biol. V. 337 675 2004.
ISSN: ISSN 0022-2836
PubMed: 15019786
DOI: 10.1016/J.JMB.2004.01.055
Page generated: Sat Oct 5 11:56:10 2024

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