Manganese in PDB 1oab: Crystal Structure of the Tyrosine Regulated 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate Synthase From Saccharomyces Cerevisiae in Complex with Phosphoenolpyruvate and Manganese(II)

Enzymatic activity of Crystal Structure of the Tyrosine Regulated 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate Synthase From Saccharomyces Cerevisiae in Complex with Phosphoenolpyruvate and Manganese(II)

All present enzymatic activity of Crystal Structure of the Tyrosine Regulated 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate Synthase From Saccharomyces Cerevisiae in Complex with Phosphoenolpyruvate and Manganese(II):
4.1.2.15;

Protein crystallography data

The structure of Crystal Structure of the Tyrosine Regulated 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate Synthase From Saccharomyces Cerevisiae in Complex with Phosphoenolpyruvate and Manganese(II), PDB code: 1oab was solved by V.Koenig, A.Pfeil, G.Heinrich, G.H.Braus, T.R.Schneider, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	20.00 / 1.9
*Space group*	C 1 2 1
*Cell size a, b, c (Å), α, β, γ (°)*	196.636, 50.502, 64.930, 90.00, 106.36, 90.00
*R / R_free (%)*	16 / 20.2

Manganese Binding Sites:

The binding sites of Manganese atom in the Crystal Structure of the Tyrosine Regulated 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate Synthase From Saccharomyces Cerevisiae in Complex with Phosphoenolpyruvate and Manganese(II) (pdb code 1oab). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the Crystal Structure of the Tyrosine Regulated 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate Synthase From Saccharomyces Cerevisiae in Complex with Phosphoenolpyruvate and Manganese(II), PDB code: 1oab:
Jump to Manganese binding site number: 1; 2;

Manganese binding site 1 out of 2 in 1oab

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Manganese Binding Sites List in 1oab

Manganese binding site 1 out of 2 in the Crystal Structure of the Tyrosine Regulated 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate Synthase From Saccharomyces Cerevisiae in Complex with Phosphoenolpyruvate and Manganese(II)

Mono view

Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Crystal Structure of the Tyrosine Regulated 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate Synthase From Saccharomyces Cerevisiae in Complex with Phosphoenolpyruvate and Manganese(II) within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Mn400 b:14.2 occ:1.00	OE2	A:GLU316	2.0	13.2	1.0
	O	A:HOH2207	2.1	21.5	1.0
	OD2	A:ASP342	2.2	15.4	1.0
	NE2	A:HIS282	2.2	11.8	1.0
	SG	A:CYS76	2.6	10.5	1.0
	CD	A:GLU316	2.9	12.4	1.0
	CG	A:ASP342	3.1	13.0	1.0
	CD2	A:HIS282	3.1	16.5	1.0
	OE1	A:GLU316	3.2	15.6	1.0
	CE1	A:HIS282	3.3	18.3	1.0
	O1	A:PEP508	3.4	22.6	1.0
	CB	A:ASP342	3.6	11.7	1.0
	CB	A:CYS76	3.7	12.0	1.0
	C1	A:PEP508	3.8	21.8	1.0
	NZ	A:LYS112	3.9	11.9	1.0
	OD1	A:ASP342	4.1	13.1	1.0
	C2	A:PEP508	4.2	23.8	1.0
	NH2	A:ARG107	4.2	10.6	1.0
	C3	A:PEP508	4.2	20.0	1.0
	CG	A:GLU316	4.3	10.8	1.0
	O	A:HOH2170	4.3	18.8	1.0
	CA	A:CYS76	4.3	13.0	1.0
	CG	A:HIS282	4.3	16.0	1.0
	ND1	A:HIS282	4.3	14.3	1.0
	O2'	A:PEP508	4.4	23.2	1.0
	CE	A:LYS112	4.7	14.5	1.0
	CA	A:ASP342	4.8	12.9	1.0
	N	A:ASP342	4.8	12.4	1.0
	O	A:CYS76	4.9	11.7	1.0
	CZ	A:ARG107	4.9	14.7	1.0
	C	A:CYS76	5.0	13.2	1.0

Manganese binding site 2 out of 2 in 1oab

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Manganese Binding Sites List in 1oab

Manganese binding site 2 out of 2 in the Crystal Structure of the Tyrosine Regulated 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate Synthase From Saccharomyces Cerevisiae in Complex with Phosphoenolpyruvate and Manganese(II)

Mono view

Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Crystal Structure of the Tyrosine Regulated 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate Synthase From Saccharomyces Cerevisiae in Complex with Phosphoenolpyruvate and Manganese(II) within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
B:Mn400 b:14.0 occ:1.00	OE2	B:GLU316	1.9	11.1	1.0
	OD2	B:ASP342	2.1	11.2	1.0
	O	B:HOH2206	2.2	20.4	1.0
	NE2	B:HIS282	2.3	12.1	1.0
	SG	B:CYS76	2.6	9.2	1.0
	CD	B:GLU316	2.8	12.5	1.0
	CG	B:ASP342	3.0	14.9	1.0
	OE1	B:GLU316	3.1	13.6	1.0
	CE1	B:HIS282	3.2	13.5	1.0
	CD2	B:HIS282	3.2	11.9	1.0
	O1	B:PEP508	3.4	23.1	1.0
	CB	B:ASP342	3.5	13.4	1.0
	CB	B:CYS76	3.6	10.1	1.0
	C1	B:PEP508	3.8	20.6	1.0
	NZ	B:LYS112	4.0	10.1	1.0
	OD1	B:ASP342	4.1	15.5	1.0
	O	B:HOH2187	4.2	38.2	1.0
	CG	B:GLU316	4.2	11.4	1.0
	CA	B:CYS76	4.2	10.4	1.0
	NH2	B:ARG107	4.2	11.3	1.0
	C2	B:PEP508	4.2	19.8	1.0
	ND1	B:HIS282	4.3	12.8	1.0
	O	B:HOH2179	4.3	14.5	1.0
	CG	B:HIS282	4.3	9.5	1.0
	C3	B:PEP508	4.4	19.8	1.0
	O2'	B:PEP508	4.5	21.5	1.0
	CA	B:ASP342	4.8	13.8	1.0
	CE	B:LYS112	4.8	12.9	1.0
	N	B:ASP342	4.8	14.3	1.0
	O	B:CYS76	4.8	11.0	1.0
	C	B:CYS76	4.9	10.9	1.0
	CZ	B:ARG107	4.9	14.5	1.0

Reference:

V.Koenig, A.Pfeil, G.H.Braus, T.R.Schneider. Substrate and Metal Complexes of 3-Deoxy-D- Arabino-Heptulosonate-7-Phosphate Synthase From Saccharomyces Cerevisiae Provide New Insights Into the Catalytic Mechanism J.Mol.Biol. V. 337 675 2004.
ISSN: ISSN 0022-2836
PubMed: 15019786
DOI: 10.1016/J.JMB.2004.01.055

Page generated: Sat Oct 5 11:56:10 2024

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