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Manganese in PDB 1luv: Catalytic and Structural Effects of Amino-Acid Substitution at His 30 in Human Manganese Superoxide Dismutase: Insertion of Val Cgamma Into the Substrate Access Channel

Enzymatic activity of Catalytic and Structural Effects of Amino-Acid Substitution at His 30 in Human Manganese Superoxide Dismutase: Insertion of Val Cgamma Into the Substrate Access Channel

All present enzymatic activity of Catalytic and Structural Effects of Amino-Acid Substitution at His 30 in Human Manganese Superoxide Dismutase: Insertion of Val Cgamma Into the Substrate Access Channel:
1.15.1.1;

Protein crystallography data

The structure of Catalytic and Structural Effects of Amino-Acid Substitution at His 30 in Human Manganese Superoxide Dismutase: Insertion of Val Cgamma Into the Substrate Access Channel, PDB code: 1luv was solved by A.S.Hearn, M.E.Stroupe, C.A.Ramilo, J.P.Luba, D.E.Cabelli, J.A.Tainer, D.N.Silverman, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.91 / 1.85
Space group P 61 2 2
Cell size a, b, c (Å), α, β, γ (°) 79.901, 79.901, 241.125, 90.00, 90.00, 120.00
R / Rfree (%) 25.4 / 28.8

Manganese Binding Sites:

The binding sites of Manganese atom in the Catalytic and Structural Effects of Amino-Acid Substitution at His 30 in Human Manganese Superoxide Dismutase: Insertion of Val Cgamma Into the Substrate Access Channel (pdb code 1luv). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the Catalytic and Structural Effects of Amino-Acid Substitution at His 30 in Human Manganese Superoxide Dismutase: Insertion of Val Cgamma Into the Substrate Access Channel, PDB code: 1luv:
Jump to Manganese binding site number: 1; 2;

Manganese binding site 1 out of 2 in 1luv

Go back to Manganese Binding Sites List in 1luv
Manganese binding site 1 out of 2 in the Catalytic and Structural Effects of Amino-Acid Substitution at His 30 in Human Manganese Superoxide Dismutase: Insertion of Val Cgamma Into the Substrate Access Channel


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Catalytic and Structural Effects of Amino-Acid Substitution at His 30 in Human Manganese Superoxide Dismutase: Insertion of Val Cgamma Into the Substrate Access Channel within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn199

b:22.1
occ:1.00
 OD1 A:ASP159 2.0 22.6 1.0
NE2 A:HIS163 2.1 23.4 1.0
O A:HOH200 2.2 19.0 1.0
NE2 A:HIS26 2.2 23.2 1.0
NE2 A:HIS74 2.3 22.1 1.0
CE1 A:HIS163 2.9 23.2 1.0
CG A:ASP159 3.1 22.3 1.0
CE1 A:HIS74 3.1 21.5 1.0
CE1 A:HIS26 3.2 23.5 1.0
CD2 A:HIS163 3.2 23.2 1.0
CD2 A:HIS26 3.2 24.0 1.0
CD2 A:HIS74 3.4 21.8 1.0
OD2 A:ASP159 3.5 21.4 1.0
CZ2 A:TRP123 4.1 21.9 1.0
ND1 A:HIS163 4.1 22.9 1.0
CG A:HIS163 4.2 23.5 1.0
ND1 A:HIS26 4.3 23.0 1.0
ND1 A:HIS74 4.3 21.7 1.0
CG A:HIS26 4.3 22.9 1.0
CB A:ASP159 4.4 22.9 1.0
CG A:HIS74 4.4 21.9 1.0
NE2 A:GLN143 4.5 22.0 1.0
CB A:TRP161 4.5 21.7 1.0
CH2 A:TRP123 4.6 21.7 1.0
CG A:TRP161 4.7 21.9 1.0
CB A:ALA164 4.9 22.6 1.0
CD1 A:TRP161 4.9 22.1 1.0
CE2 A:TRP123 4.9 22.0 1.0

Manganese binding site 2 out of 2 in 1luv

Go back to Manganese Binding Sites List in 1luv
Manganese binding site 2 out of 2 in the Catalytic and Structural Effects of Amino-Acid Substitution at His 30 in Human Manganese Superoxide Dismutase: Insertion of Val Cgamma Into the Substrate Access Channel


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Catalytic and Structural Effects of Amino-Acid Substitution at His 30 in Human Manganese Superoxide Dismutase: Insertion of Val Cgamma Into the Substrate Access Channel within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mn200

b:20.5
occ:1.00
 O B:HOH201 2.0 20.3 1.0
OD1 B:ASP159 2.0 19.5 1.0
NE2 B:HIS74 2.2 20.4 1.0
NE2 B:HIS163 2.2 18.0 1.0
NE2 B:HIS26 2.4 18.1 1.0
CG B:ASP159 3.1 19.2 1.0
CE1 B:HIS74 3.1 21.0 1.0
CD2 B:HIS74 3.2 20.7 1.0
CE1 B:HIS163 3.2 17.8 1.0
CD2 B:HIS163 3.2 17.1 1.0
CE1 B:HIS26 3.3 18.8 1.0
CD2 B:HIS26 3.4 18.0 1.0
OD2 B:ASP159 3.5 18.8 1.0
ND1 B:HIS74 4.2 21.3 1.0
CZ2 B:TRP123 4.3 18.6 1.0
CG B:HIS74 4.3 21.1 1.0
ND1 B:HIS163 4.3 16.7 1.0
CG B:HIS163 4.4 17.8 1.0
CB B:ASP159 4.4 18.8 1.0
ND1 B:HIS26 4.5 18.1 1.0
NE2 B:GLN143 4.5 17.0 1.0
CG B:HIS26 4.6 18.3 1.0
CB B:TRP161 4.6 16.4 1.0
CG B:TRP161 4.7 16.3 1.0
CH2 B:TRP123 4.9 18.7 1.0
CB B:ALA164 4.9 19.0 1.0
CD1 B:TRP161 4.9 17.2 1.0

Reference:

A.S.Hearn, M.E.Stroupe, D.E.Cabelli, C.A.Ramilo, J.P.Luba, J.A.Tainer, H.S.Nick, D.N.Silverman. Catalytic and Structural Effects of Amino Acid Substitution at Histidine 30 in Human Manganese Superoxide Dismutase: Insertion of Valine C Gamma Into the Substrate Access Channel Biochemistry V. 42 2781 2003.
ISSN: ISSN 0006-2960
PubMed: 12627943
DOI: 10.1021/BI0266481
Page generated: Sat Oct 5 11:37:08 2024

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